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  • Springer  (101)
  • American Meteorological Society (AMS)
  • 1985-1989  (65)
  • 1970-1974  (22)
  • 1935-1939  (14)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Purines and cortisone in lipid mobilization (1970)
    Springer
    Cellular and molecular life sciences 26 (1970), S. 128-129 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Purin-Basen, Kaffein und Cortison führen zu einer Vermehrung der Fettsäuren im Rattenserum. Adenin vermindert im Gegensatz zu den anderen Purinen die Lipolyse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01895532
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  • 2
    Electronic Resource
    Electronic Resource
    Ion association reactions with biological membranes, studied with the fluorescent dye 1-anilino-8-naphthalenesulfonate (1970)
    Springer
    The journal of membrane biology 3 (1970), S. 241-266 
    Details
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary (1) When salts are added to buffered suspensions of membrane fragments containing the fluorochrome 1-anilino-8-naphthalenesulfonate (ANS), there is an increased fluorescence. This is caused by increased binding of the fluorochrome; the intrinsic fluorescence characteristics of the bound dye remain unaltered. These properties make ANS a sensitive and versatile indicator of ion association equilibria with membranes. (2) Alkali metal and alkylammonium cations bind to membranes in a unique manner. Cs+ binds most strongly to rat brain microsomal material, with the other alkali metals in the order Cs+〉Rb+〉K+〉Na+〉Li+. The reaction is endothermic and entropy driven. Monovalent cations are displaced by other monovalent cations. Divalent cations and some drugs (e. g., cocaine) displace monovalent cations more strongly. (3) Divalent cations bind to membranes (and to lecithin micelles) at four distinct sites, having apparent association constants between 50 and 0.2mm −1. The characteristics of the titration suggest that only one species of binding site is present at any one time, and open the possibility that structural transitions of the unassociated coordination sites may be induced by divalent cation binding. Divalent cation binding at the weakest site (like monovalent cation binding) is endothermic and entropy driven. At the next stronger site, the reaction is exothermic. Monovalent cations affect divalent cation binding by reducing the activity coefficient: they do not appear to displace divalent cations from their binding sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01868018
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  • 3
    Electronic Resource
    Electronic Resource
    A method for the isolation of nuclei from the dermatophytic fungus,Microsporum gypseum (1974)
    Springer
    Archives of microbiology 96 (1974), S. 281-289 
    Details
    ISSN: 1432-072X
    Keywords: Fungal Nuclei ; Isolation ; Purification ; Characterization ; Dermatophyte ; Microsporum gypseum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A method is reported for the isolation of nuclei from the dermatophytic fungus,Microsporum gypseum. The yield ranged from greater than 90% in crude preparations to less than 20% in highly purified preparations as judged by the recovery of DNA. Nuclei isolated in this manner appeared intact in electron microscopic observations and possessed chemical compositions, i.e. low protein/DNA and RNA/DNA ratios, which indicated a low degree of cytoplasmic contamination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00590184
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  • 4
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of 6-thiouric acid and 6-mercaptopurine in renal allograft recipients after oral administration of azathioprine (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 265-271 
    Details
    ISSN: 1432-1041
    Keywords: azathioprine ; 6-thiouric acid ; 6-mercaptopurine ; renal transplantation ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The immunosuppressive activity of azathioprine (AZA) is unpredictable and depends on the formation of intracellular thiopurine ribonucleotides. However, the quantification of these active thiopurines presents difficult analytical problems. It has recently been postulated that plasma concentrations of 6-thiouric acid (6-TU) and 6-mercaptopurine (6-MP), metabolites of AZA, may provide more readily measurable indices of the pharmacologic activity of AZA. In order to evaluate the utility of 6-TU and 6-MP plasma concentrations in monitoring AZA therapy, we studied their pharmacokinetics in 6 renal transplant patients, and their in vitro immunosuppressive potency in a mixed lymphocyte proliferation assay. A peak plasma 6-TU concentration of 710.7 ng/ml was observed at 3.8 h after oral dosing. Good correlation was observed between the elimination t1/2 of 6-TU and serum creatinine, and between AUC over 24 h and serum creatinine. However, we did not observe a second peak in plasma 6-TU concentration that could be attributed to the degradation of active AZA metabolites. 6-MP plasma concentrations in the patients were low (mean peak concentration 36.0 ng/ml) and rapidly disappeared within 8 h. In vitro immunosuppressive activity could not be demonstrated for 6-TU over a concentration range of 1.25 ng/ml to 0.25 mg/ml. We conclude that 6-TU is pharmacologically inert and is primarily eliminated by the kidneys. Our findings currently do not support the use of plasma concentrations of 6-TU or 6-MP to monitor AZA therapy. In order to optimize AZA therapy, analytical techniques that are technically feasible and that can directly quantify the active intracellular thiopurines are being explored.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558158
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  • 5
    Electronic Resource
    Electronic Resource
    Ladungszahl und Polymerisationsgrad des Metawolframations in wäßriger NaCl-haltiger Lösung nach Untersuchungen des Sedimentationsgleichgewichtes mit der Ultrazentrifuge (1971)
    Springer
    Colloid & polymer science 249 (1971), S. 1148-1154 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Summary The chargez of the meta-tungstate ion in the ternary system Na6[H2W12O40]-NaCl-H2O is determined by ultracentrifugation experiments, evaluating the experimental data: 1. according to the limiting value ofLamm by eytrapolating the apparent molecular weight to zero-concentration, 2. according to the procedure ofJohnson, Kraus andScatchard. The discrepancy of the results ¦z¦=6 versus ¦z¦=2,85 is resolved by giving the proof that the latter value has no physical significance. For the molecular weight the first method gives the exact value, the second furnishes a very satisfying approximation.
    Notes: Zusammenfassung Die Ladungszahlz des Metawolframations in dem ternären System Na6[H2W12O40]-NaCl-H2O wird nach zwei verschiedenen Verfahren durch Untersuchung des Sedimentations—Diffusionsgieichgewichtes mit der Ultrazentrifuge bestimmt: 1. Mit Hilfe der Lammschen Grenzbeziehung durch Extrapolation der scheinbaren Molmasse auf die Konzentration Null und 2. nach der Methode vonJohnson, Kraus undScatchard. Die Ergebnisse sind ¦z¦=6 bzw. ¦z¦=2,85. Es wird gezeigt, daß dem nach dem Verfahren vonJohnson, Kraus undScatchard erhaltenen Wert ¦z¦=2,85 keine physikalische Realitat zukommt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01556986
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  • 6
    Electronic Resource
    Electronic Resource
    Influence of sex on the urinary bilirubin excretion at increased free plasma haemoglobin levels in whole dogs and in isolated normothermic perfused dog kidneys (1971)
    Springer
    Cellular and molecular life sciences 27 (1971), S. 1264-1265 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Si le taux sanguin en hémoglobine libre dépasse les 50 mg/100 ml, l'excrétion rénale de la bilirubine est fortement augmentée chez le chien, tandis qu'elle reste faible chez la chienne. Les mêmes résultats sont obtenues par perfusion de reins isolés avec du sang hépariné ou défibriné.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02136676
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  • 7
    Electronic Resource
    Electronic Resource
    Degradation of haemoglobin-14C and urinary excretion of bilirubin-14C by the normothermic perfused isolated dog kidney (1973)
    Springer
    Cellular and molecular life sciences 29 (1973), S. 410-411 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé L'hémoglobine libre du sang, filtrée par les glomérules rénaux et partiellement absorbée par les tubules, est métabolisée par le tissu renal. A l'aide de l'hémoglobine marquée en14C, formée à partir de la glycine-2-14C et de la glycine-1-14C nos résultats prouvent que chez le chien mâle les reins métabolisent l'hémoglobine en bilirubine conjugée et excrètent cette dernière dans les urines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01926750
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  • 8
    Electronic Resource
    Electronic Resource
    A note on rings having only a finite number of cyclic indecomposable modules (1986)
    Springer
    Archiv der Mathematik 47 (1986), S. 408-409 
    Details
    ISSN: 1420-8938
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01189979
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  • 9
    Electronic Resource
    Electronic Resource
    Evolutionary conservatism in arrangement of genetic material (1973)
    Springer
    Chromosoma 43 (1973), S. 211-224 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The diploid number of the Rhesus macaque, Macaca mulatta, is 42. All chromosomes are biarmed and all constitutive heterochromatins are centromeric. The diploid number of the African Green monkey, Cercopithecus aethiops, is 60. Again all chromosomes are biarmed, but seven pairs possess very short second arms which are heterochromatic. The heterochromatins of remaining chromosomes are centromeric. Using G-banding and deleting the heterochromatic short arms, the chromosomes of the African Green monkey can be artificially fused to reconstruct a karyotype of the Rhesus with only one pair of unmatched small metacentrics. In addition to the Robertsonian type of translocations, several sets of centromere-telomere translocations were found. The latter type of translocation reduced three arms into two. Thus the fundamental number can be changed by two mechanisms: growing extra heterochromatic arms and the centromere-telomere fusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00483380
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  • 10
    Electronic Resource
    Electronic Resource
    Molecular analysis of mitochondrial DNA from tomato cell suspension cultures (1986)
    Springer
    Current genetics 10 (1986), S. 785-790 
    Details
    ISSN: 1432-0983
    Keywords: Plant mitochondrial DNA ; Restriction enzyme analysis ; rRNA genes ; Tomato cell suspension cultures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Mitochondrial DNA (mtDNA) from Lycopersicon esculentum was purified from cell suspension cultures. The DNA, isolated from mitochondria purified by two successive sucrose density gradients, was uncontaminated with nuclear DNA or DNA from proplastids. The total molecular weights of BamHI, BglI, and BglII fragments indicate a mitochondrial genome size of at least 270 kb. Cross hybridization between tomato mtDNA and cloned spinach plastid genes revealed some homology. In hybridization experiments using cloned mitochondrial rRNA genes and BamHI digested total mtDNA the presence of recombination repeats is demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00405102
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