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  • 1985-1989  (20)
  • 1975-1979  (26)
  • 1910-1914  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance (1977)
    Springer
    European journal of clinical pharmacology 11 (1977), S. 287-293 
    Details
    ISSN: 1432-1041
    Keywords: Rifampicin ; induction of drug metabolism ; cirrhosis ; cholestasis ; hexobarbital kinetics ; tolbutamide kinetics ; plasma concentrations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Eleven patients with hepatic cirrhosis or cholestasis were treated with rifampicin for 7 to 132 days. Ten patients received hexobarbital (7.32 mg/kg) and five received tolbutamide (20 mg/kg) by i.v. infusion prior to and after rifampicin treatment; plasma concentrations of the two test compounds were determined during and after infusion. The average elimination half-life of hexobarbital had decreased from 624 to 262 min and that of tolbutamide from 292 to 160 min following rifampicin treatment. It was calculated that the metabolic clearance of hexobarbital had increased more than two-fold and that of tolbutamide almost two-fold. The results suggest that rifampicin is able to stimulate hepatic drug metabolism in patients with liver disease. It was apparent in general that the induction did not lead to improvement of hepatocellular function during disease as judged by laboratory findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607679
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  • 2
    Electronic Resource
    Electronic Resource
    Confined phonons in (GaAs)n1(AlAs)n2 superlattices grown along the [012] direction (1989)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 54 (1989), S. 846-848 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The short-period (GaAs)n1(AlAs)n2 superlattices with parameters (n1,n2)=(21,25), (6,42), (14,16), and (23,8) have been grown by molecular beam epitaxy on GaAs substrates along the [012] direction and characterized by x-ray and Raman scattering spectroscopy. The appearance of distinct satellite peaks around the Bragg reflections demonstrates the formation of high quality superlattices. The observed TO and LO confined modes have frequencies which map closely those of the optical phonons of bulk GaAs and AlAs in the Γ-W-X direction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.101415
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  • 3
    Electronic Resource
    Electronic Resource
    Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance (1975)
    Springer
    European journal of clinical pharmacology 9 (1975), S. 219-227 
    Details
    ISSN: 1432-1041
    Keywords: Rifampicin ; induction of drug metabolism ; hexobarbital kinetics ; tolbutamide kinetics ; plasma concentrations ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Five healthy volunteers took 1.2 g rifampicin daily for 8 days, and before and afterwards each received hexobarbital (7.32 mg/kg) and tolbutamide (20 mg/kg) by i.v. infusion on two consecutive days. The plasma concentrations of the two drugs were determined during and after infusion. The average elimination half-life of hexobarbital had decreased from 325 to 122 min and of tolbutamide from 418 to 183 min following rifampicin treatment. It was calculated that the metabolic clearance of hexobarbital had increased about three-fold and that of tolbutamide more than two-fold. Significant changes in the distribution kinetics of the two drugs were not observed. The results suggest that rifampicin is capable of inducing drug metabolism in man, which leads to an increased rate of elimination of drugs that undergo biotransformation in the liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614021
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  • 4
    Electronic Resource
    Electronic Resource
    Zum Nachweise der Perborsäure und einiger ähnlicher Verbindungen (1911)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 50 (1911), S. 537-544 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01359306
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  • 5
    Electronic Resource
    Electronic Resource
    57Fe conversion electron Mössbauer spectrometric study of boron and carbon ion implanted irons (1988)
    Springer
    Hyperfine interactions 42 (1988), S. 985-988 
    Details
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Amorphous layers produced at the surface of iron by B+ and C+ implantation (50 kV, 1×1018 ions cm−2) were analyzed by CEMS. The CEM spectrum of B+ implanted layer was composed of broad doublet and sextet. Spread hyperfine field distribution, P(H), indicates the formation of extremely disordered FeB layer. Annealing at 400°C brought about precipitation of FeB, which was converted to Fe2B by annealing at 500°C. The P(H) for C+ implanted iron was resolved to 3 subpeaks with H values of 11.0, 18.0 and 22.5 T. The amorphous FeC phase was strongly correlated to crystalline Fe5C2 and Fe2C, which precipitated at 300°C and were transformed into Fe3C at 500°C. The amorphous layer disappeared by annealing at 600°C.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02395555
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  • 6
    Electronic Resource
    Electronic Resource
    RBS investigations of ion beam mixed hard coatings on tool steel (1988)
    Springer
    Journal of radioanalytical and nuclear chemistry 122 (1988), S. 321-326 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Silicon nitride hard coatings on tool steel produced by ion beam mixing following sputter or vapour deposition were investigated by RBS and Vickers microhardness measurements. Atomic mixing in the coating/steel interface region resulting in an improved adhesion and in a significant increase of the microhardness of the surface layers was found. Ion beam mixing with gas ions and high fluences leads to blistering of the implanted atoms in the silicon nitride layer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02037778
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  • 7
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of hexobarbital in man after intravenous infusion (1975)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 3 (1975), S. 1-11 
    Details
    ISSN: 1573-8744
    Keywords: hexobarbital pharmacokinetics ; intravenous infusion ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The plasma levels of hexobarbital in humans were determined during and after a 30-min or 60-min zero-order intravenous infusion. Hexobarbital kinetics could be described by conceiving the body to exhibit two compartments. The plasma concentrations were fitted to the postinfusion equation and the parameters intrinsic to the two- compartment open model were estimated. The elimination half-life varied considerably among the 14 individuals (160–441 min), which could mainly be explained by the greatly varying metabolic clearance of the compound (123–360 ml /min). The apparent volume of distribution per kilogram of body weight was relatively constant (1.10±0.12 liters/kg).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01066591
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  • 8
    Electronic Resource
    Electronic Resource
    Sulfur, Energy, and Environment. Von B. Meyer. Elsevier Scientific Publishing Company, Amsterdam - New York 1977, 1. Aufl., XII, 448 S., zahlr. Abb. u. Tab., Kunststoffeinbd., Dfl. 97.00. (1978)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 50 (1978), S. 561-561 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330500724
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  • 9
    Electronic Resource
    Electronic Resource
    Quantitative analysis of ethylenediamine in plasma by capillary column gas chromatography (1986)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 9 (1986), S. 548-554 
    Details
    ISSN: 0935-6304
    Keywords: Gas liquid chromatography (GLC) ; Fused silica capillary columns ; Alkali flame ionization detection (AFID) ; Mass spectrometry (MS) ; Quantitation in human serum ; Ethylenediamine ; Aminophylline ; Small molecular weight amines and diamines ; m-Toluoyl derivatives ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A specific and sensitive method for the determination of ethylenediamine in human plasma is described. The aqueous sample is treated with m-toluoyl chloride, yielding the N,N′-bis(m-toluoyl) derivative of the diamine, which is extracted into dichloromethane and quantitated after “on column” methylation by capillary gas liquid chromatography with alkali flame ionization detection. The corresponding derivative of putrescine serves as internal standard. The assay is reproducible and calibration curves are linear over the concentration range 0.05 to 10 μg · ml-1. The lower detection limit is about 10 ng · ml-1. The structures of the compounds of interest eluting from the capillary column are examined by gas liquid chromatography/mass spectrometry. The assay has been applied to the analysis of ethylenediamine in plasma following the administration of aminophylline and ethylenediamine in a cross-over study to patients with bronchopulmonary diseases. The method also proves suitable for measuring other primary and secondary amines and diamines in aqueous solutions by gas liquid chromatography.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240091002
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  • 10
    Electronic Resource
    Electronic Resource
    Kinetics of fast (RIM) urethane polymerizationPresented in part at the AIChE Annual Meeting, Chicago (Dec. 1976). (1978)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 18 (1978), S. 1012-1018 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The kinetics of the dibutyltin dilaurate catalyzed bulk polymerization of 4,4′-diphenylmethane diisocyanate (MDI) with poly-∊-caprolactone were studied by infared spectroscopy and adiabatic temperature rise. The overall reaction order was found to change from 3/2 to 2 with increasing temperature. At temperatures above 80°C, the order with respect to catalyst was found to decrease with concentration from 1 to 1/2. The results were consistent with a Michaelis Menten type kinetic scheme.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760181308
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