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  • 1
    Monograph available for loan
    Monograph available for loan
    Princeton, NJ : Princeton Univ. Press
    Call number: M 95.0126
    Type of Medium: Monograph available for loan
    Pages: xi,386 S.
    ISBN: 0691036349
    Classification:
    A.2.1.
    Language: English
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 118 (1994), S. 0 
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: There are many techniques for modelling the geomagnetic field, any one of which may be suitable for a particular application depending on its associated modelling goals. Each method combines a choice of functions and an approach to fitting data so that, in general, it is best suited to a particular type of field modelling, e.g. core versus crustal, regional versus global, downward continuation versus interpolation. Those few approaches such as spherical cap harmonic analysis (Haines 1985a) that possess any true flexibility in this respect suffer from mathematical and computational complexity. In addition, regularization is still a somewhat overlooked issue. Regularization is essential for downward continuing geomagnetic data because shorter wavelength field components and their errors blow up in this process. Approaches such as harmonic spline modelling (Shure, Parker & Backus 1982) which include regularization do so while significantly complicating the task of inversion. We present a new regularized modelling scheme which employs magnetic monopoles as representing functions. We apply regularizing norms of the type introduced by Shure et al. (1982). Owing to the mathematical simplicity of the monopoles, the expressions for the norms are themselves very simple and flexible, and the monopole models very easy to compute. Moreover, the conceptual simplicity of this representation allows for easy modification to accommodate most geomagnetic modelling problems. We apply the technique to problems on three different length scales, each application having distinctly different modelling goals: globally we model the radial core field at the core-mantle boundary (CMB) from satellite data; on a large regional scale we model the radial crustal field at the earth's surface from satellite data; on a small regional scale we model the radial crustal field at the earth's surface from surface data. For each of these varied applications we are able to generate monopole models which produce smooth, plausible fields that fit the data.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 113 (1993), S. 0 
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Techniques for modelling the geomagnetic field at the surface of Earth's core often penalize contributions at high spherical harmonic degrees to reduce the effect of mapping crustal fields into the resulting field model at the core-mantle boundary (CMB). Ambiguity in separating the observed field into crustal and core contributions makes it difficult to assign error bounds to core field models, and this makes it hard to test hypotheses that involve pointwise values of the core field. The frozen-flux hypothesis, namely that convective terms dominate diffusive terms in the magnetic-induction equation, requires that the magnetic flux through every patch on the core surrounded by a zero contour of the radial magnetic field remains constant, although the shapes, areas and locations (but not the topology) of these patches may change with time. Field models exactly satisfying the conditions necessary for the hypothesis have not yet been constructed for the early part of this century. We show that such models must exist, so testing the frozen-flux hypothesis becomes the question of whether the models satisfying it are geophysically unsatisfactory on other grounds, for example because they are implausibly rough or complicated. We introduce an algorithm to construct plausible field models satisfying the hypothesis, and present such models for epochs 1945.5 and 1980.Our algorithm is based on a new parametrization of the field in terms of its radial component Br at the CMB. The model consists of values of Br at a finite set of points on the CMB, together with a rule for interpolating the values to other points. The interpolation rule takes the specified points to be the vertices of a spherical triangle tessellation of the CMB, with Br varying linearly in the gnomonic projections of the spherical triangles onto planar triangles in the planes tangent to the centroids of the spherical triangles. This parametrization of Br provides a direct means of constraining the integral invariants required by the frozen-flux hypothesis.Using this parametrization, we have constructed field models satisfying the frozen-flux hypothesis for epochs 1945.5 and 1980, while fitting observatory and survey data for 1945.5 and Magsat data for 1980. We use the better constrained 1980 CMB field model as a reference for 1945.5: we minimize the departure of the 1945.5 CMB field model from a regularized 1980 CMB field model, while constraining the 1945.5 model to have the same null-flux curves and flux through those curves as the 1980 model. The locations, areas and shapes of the curves are allowed to change. The resulting 1945.5 CMB field model is nearly as smooth as that for 1980, fits the data adequately, and satisfies the conditions necessary for the frozen-flux hypothesis.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Abacus 30 (1994), S. 0 
    ISSN: 1467-6281
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: Accounting historians have shown considerable interest in the first printed books published on accounting (from 1494 onwards) in various countries. This paper provides a detailed study of the first Australian book, published in sets between 1871 and 1873. It examines the factors determining the date and place of such first authorship. James Dimelow's life and career in Britain and Australia are discussed and his books (which were published in Britain as well as Australia) are systematically described. These books are placed within the contexts of the economic and cultural environment of colonial Australia and the nineteenth-century British and Australian accounting literature. The differences between Dimelow's and John Scouller's books are explored and explained and possible influences of Dimelow on the later development of Australian accounting are proposed.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 691 (1993), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-0646
    Keywords: dihydrolenperone ; drug evaluation ; drug screening assays ; antitumor ; carcinoma ; non-small cell lung carcinoma ; oat cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Antitumor activity of the butyrophenone dihydrolenperone in non-small cell lung cancer was initially suggested byin vitro screening against tumor cells derived from fresh surgical samples using the human tumor colony-forming assay. We have completed a directed phase I trial in patients with lung cancer. Thirty-two patients with lung cancer have completed 25 courses of therapy at doses of 10 to 60 mg/square meter orally on a twice daily schedule. Twenty-three men and 9 women with a median age of 55 (range 24–69) were entered. Twenty-four were performance status 0 or 1 and 8 were 2. The maximum tolerated dose was 50 mg/square meter orally twice daily and the dose limiting toxicity was somnolence. Of the 32 patients, 18 developed symptomatic hypotension (grade 1 or 2). There was no significant hematologic, renal, or hepatic toxicity.In vitro drug testing using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (thiazolyl blue)] assay confirmed 50% inhibition of non-small cell and small cell lung cancer cell line growth at 70–450 micromolar concentrations. Plasma dihydrolenperone levels were at least 75-fold less than levels at whichin vitro activity was observed. We conclude: 1) the maximum tolerated dose in our study is 50 mg/square meter orally twice daily, 2) the dose-limiting side effect of dihydrolenperone is somnolence, and 3) the concentrations of dihydrolenperone observed in plasma are significantly lower than those associated within vitro activity.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 151 (1992), S. 50-55 
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: SV40 large T oncoprotein-transformed murine mesenchymal 3T3 T stem cells (CSV3 cells) can be induced to growth arrest and then differentiate into adipocytes. When differentiation occurs, SV40 T oncoprotein expression is repressed (Estervig et al., J Virol 63:2713, 1989). To determine if repression of T oncoprotein expression can also be induced pharmacologically, the effect of a variety of agents that have been reported to effect differentiation in various cell types but not in 3T3 T or CSV3 cells was tested. This rationale suggests that if any of these agents repress T oncoprotein expression in CSV3 cells, then the results would establish that repression of T oncoprotein expression can be mediated by mechanisms independent of overt differentiation. The results show that dimethylsulfoxide (DMSO) is the only agent tested that represses T oncoprotein expression in CSV3 cells. Repression occurs in a dosage-dependent manner within 24-96 hours after exposure to DMSO. The effect of DMSO on T oncoprotein expression is mediated by posttranslational mechanisms that decrease the stability of the T oncoprotein. DMSO-induced repression of T oncoprotein expression is also associated with reversion of the transformed phenotype in CSV3 cells as demonstrated by the loss of responsiveness to a specific transformation-associated mitogen. These data support the conclusion that the pharmacological repression of T oncoprotein expression represents a form of cancer suppressor activity that can be mediated by a distinct molecular mechanism. © 1992 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Publication Date: 1991-11-25
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 10
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