ISSN:
0899-0042
Keywords:
optical resolution
;
enantioselectivity
;
chromatography
;
dissociation constants
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
We present a chromatographic method for the separation and determination of the optical purity of the enantiomers of WB 4101 [(±)-1], one of the most potent and selective α1-adrenoreceptor antagonists. (±)-1 was converted into the amide of N-tosyl-(S)-proline. The two diastereoisomers were separated on silica gel and analysed by HPLC reversed phase. The analytical method described is both accurate and sensitive and allows the optical purity to be determined at very low concentrations and to obtain WB 4101 enantiomers with a purity of more than 99.95%.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chir.530040105
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