ISSN:
1573-8221
Keywords:
antimorphine antibodies
;
chronic morphine intoxication
;
immunological reactivity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Chronic intoxication of rats with morphine during 2- and 4-week periods resulted in the emergence of antimorphine antibodies in the blood of 50 and 80% of the animals, respectively, in hemagglutination titers 1∶20 and higher. Antibodies were not detected in the control animals (not treated with morphine) but were detected in 17% of rats given alcohol during a 3-month period. The animals with a high titer of antimorphine antibodies displayed a lower level of humoral reactivity in response to immunization with a thymus-dependent antigen (sheep erythrocytes) compared with the animals with a low titer of the antibodies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02444378
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