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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1991-06-21
    Description: In order to enhance the yield and productivity of metabolite production, researchers have focused almost exclusively on enzyme amplification or other modifications of the product pathway. However, overproduction of many metabolites requires significant redirection of flux distributions in the primary metabolism, which may not readily occur following product deregulation because metabolic pathways have evolved to exhibit control architectures that resist flux alterations at branch points. This problem can be addressed through the use of some general concepts of metabolic rigidity, which include a means for identifying and removing rigid branch points within an experimental framework.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stephanopoulos, G -- Vallino, J J -- New York, N.Y. -- Science. 1991 Jun 21;252(5013):1675-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1904627" target="_blank"〉PubMed〈/a〉
    Keywords: Carbon Dioxide/metabolism ; Corynebacterium/*metabolism ; Enzymes/metabolism ; Genetic Engineering/*methods ; Glucose/metabolism ; Lysine/*biosynthesis ; *Metabolism ; NADP/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 38 (1992), S. 1254-1278 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The modular multivariable controller (MMC) represents a multivariable controller design methodology which is based on the solution of multiobjective optimization problems using the strategy of lexicographic goal programming; priority-driven, sequential satisfaction of objectives. This article formally introduces the concept of the MMC, analyzes its static characterstics, and proposes a specific methodology for the design of steady-state MMCs. It is shown that the framework of MMC can explicitly handle all types of control objectives (for example, equality or inequality specifications on controlled outputs), and constraints on manipulations. Its priority-driven, sequential satisfaction of control objectives leads to a modular, hierarchical structure of controllers with specific objectives. The modular character of MMC allows the explicit maintenance, tuning, and reconfiguration of multivariable control systems, while its hierarchical structure explicitly expresses engineering decisions and trade-offs. Its static design incorporates uncertainty in process gains and automatic reconfiguration to account for failure in sensors and/or actuators. The design of an MMC for a heavy oil fractionator is presented to illustrate the controller's character and the proposed methodology for the design of static MMCs.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 1992-08-01
    Print ISSN: 0001-1541
    Electronic ISSN: 1547-5905
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Wiley on behalf of American Institute of Chemical Engineers.
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