Publication Date:
1993-01-01
Description:
T cell receptor (TCR) vaccination in rats prevents the development of experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis. The mechanism of this potential immunotherapy was examined by vaccinating mice with an immunogenic peptide fragment of the variable region of the TCR V beta 8.2 gene. Another immunogen that usually induces an immune response mediated by V beta 8.2+ T cells was subsequently inhibited because specific clonal unresponsiveness (anergy) had been induced. Depletion of CD8+ cells before TCR peptide vaccination blocked such inhibition. Thus, the clonal anergy was dependent on CD8+ T cells, and such immunoregulatory T cells may participate in the normal course of EAE.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gaur, A -- Ruberti, G -- Haspel, R -- Mayer, J P -- Fathman, C G -- AI 27989/AI/NIAID NIH HHS/ -- DK 39959/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1993 Jan 1;259(5091):91-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Stanford University School of Medicine, CA 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8418501" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies/administration & dosage
;
Antigens, CD8/*immunology
;
Encephalomyelitis, Autoimmune, Experimental/*immunology/prevention & control
;
Lymph Nodes/immunology
;
Lymphocyte Activation
;
Lymphocyte Depletion
;
Mice
;
Mice, Inbred DBA
;
Mice, Inbred Strains
;
Receptors, Antigen, T-Cell/*immunology
;
T-Lymphocyte Subsets/*immunology
;
T-Lymphocytes/*immunology
;
*Vaccines
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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