ISSN:
0170-2041
Keywords:
Ketene O,N-acetals
;
Antifungal agents
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A Facile and Selective Synthesis of (Z)-tert-Butylketene O,N-AcetalsMelting the ketene O,O-acetals 1 with azoles in the presence of a catalytic amount of a proton acid yields the ketene O,N-acetals 2. The products of this phenol-azol substitution reaction are obtained as their (E/Z)-mixtures with the (Z)-isomers highly predominating. The (E)-isomers are easily converted into the (Z)-isomers by a proton acid catalysed isomerisation reaction.
Additional Material:
2 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199319930137
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