Publication Date:
1990-02-02
Description:
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) is an analog of the quinoxalinedione antagonists to the non-N-methyl-D-aspartate (non-NMDA) glutamate receptor. NBQX is a potent and selective inhibitor of binding to the quisqualate subtype of the glutamate receptor, with no activity at the NMDA and glycine sites. NBQX protects against global ischemia, even when administered 2 hours after an ischemic challenge.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sheardown, M J -- Nielsen, E O -- Hansen, A J -- Jacobsen, P -- Honore, T -- New York, N.Y. -- Science. 1990 Feb 2;247(4942):571-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉A/S Ferrosan, CNS Division, Soeborg, Denmark.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2154034" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Aspartic Acid/analogs & derivatives/pharmacology
;
Brain Ischemia/*drug therapy
;
Cerebral Cortex/drug effects/*physiology
;
Hippocampus/drug effects/*physiology/physiopathology
;
Ibotenic Acid/analogs & derivatives/pharmacology
;
In Vitro Techniques
;
Kainic Acid/pharmacology
;
N-Methylaspartate
;
Neurons/drug effects/physiology
;
Oxadiazoles/pharmacology
;
Pyramidal Tracts/drug effects/*physiology/physiopathology
;
Quinoxalines/metabolism/pharmacology/*therapeutic use
;
Quisqualic Acid
;
Rats
;
Receptors, Glutamate
;
Receptors, Kainic Acid
;
Receptors, Neurotransmitter/drug effects/metabolism
;
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
