Publication Date:
1993-04-16
Description:
Recombinant human macrophage inflammatory protein-1 alpha (rhMIP-1 alpha) and rhMIP-1 beta were potent chemoattractants of human T lymphocytes. These rhMIP-1 cytokines attracted only T cells activated by monoclonal antibody to CD3 and did not attract unstimulated lymphocytes. Phenotypic analysis revealed that CD4+ T cells were capable of migrating in response to rhMIP-1 beta, whereas rhMIP-1 alpha induced chemotaxis of predominantly CD8+ T lymphocytes. Activated naive and memory T cells also migrated in response to rhMIP-1 cytokines. Furthermore, these cytokines enhanced the ability of T cells to bind to an endothelial cell monolayer. These results suggest that rhMIP-1 cytokines preferentially recruit specific T cell subsets during the evolution of the immune response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taub, D D -- Conlon, K -- Lloyd, A R -- Oppenheim, J J -- Kelvin, D J -- N01-C0-74102/PHS HHS/ -- New York, N.Y. -- Science. 1993 Apr 16;260(5106):355-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick Cancer Research and Development Center (FCRDC), MD 21702.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7682337" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
Antibodies, Monoclonal/immunology
;
Antigens, CD3/immunology
;
Antigens, CD8/analysis
;
CD4-Positive T-Lymphocytes/immunology/*physiology
;
Cell Adhesion
;
Chemokine CCL4
;
Chemokine CCL5
;
*Chemotaxis, Leukocyte
;
Clone Cells
;
Cytokines/*pharmacology
;
Endothelium, Vascular/cytology
;
Humans
;
Immunologic Memory
;
*Lymphocyte Activation
;
Lymphokines/pharmacology
;
Macrophage Inflammatory Proteins
;
Monokines/*pharmacology
;
Recombinant Proteins/pharmacology
;
T-Lymphocyte Subsets/immunology/physiology
;
T-Lymphocytes, Cytotoxic/immunology/*physiology
;
T-Lymphocytes, Regulatory/immunology/*physiology
;
Umbilical Veins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
