Publication Date:
1990-01-19
Description:
The product of the yeast cell cycle control gene cdc2, and its homologs in higher eukaryotes (p34cdc2), all contain a perfectly conserved sequence of 16 amino acids that has not been found in any other protein sequence. Microinjection of this peptide triggers a specific increase in the concentration of intracellular free Ca2+ that originates from intracellular stores in both starfish and Xenopus oocytes. Thus, p34cdc2 might interact through its conserved peptide domain with some component of the Ca2(+)-regulatory system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Picard, A -- Cavadore, J C -- Lory, P -- Bernengo, J C -- Ojeda, C -- Doree, M -- New York, N.Y. -- Science. 1990 Jan 19;247(4940):327-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉CNRS and INSERM, Montpellier, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2153316" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
*CDC2 Protein Kinase
;
Calcium/*metabolism
;
Chloride Channels
;
Chlorides/metabolism
;
Cytoplasmic Granules/physiology
;
Egtazic Acid/pharmacology
;
Exocytosis/drug effects
;
Female
;
Genes, Fungal
;
Growth Substances/*genetics
;
Maturation-Promoting Factor
;
Membrane Proteins/metabolism
;
Microinjections
;
Molecular Sequence Data
;
Oocytes/drug effects/*physiology
;
*Peptide Fragments
;
Peptides/*pharmacology
;
Starfish
;
Xenopus
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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