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  • Complex dielectric constant  (1)
  • Diflunisal  (1)
  • 1990-1994  (2)
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  • 1
    Digitale Medien
    Digitale Medien
    Both phenolic and acyl glucuronidation pathways of diflunisal are impaired in liver cirrhosis (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 471-474 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Diflunisal ; Cirrhosis ; glucuronidation sulfation ; protein binding
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of diflunisal, a salicylate derivative that undergoes phenolic and acyl glucuronidation as well as sulphate conjugation, has been studied after a single oral dose (250 mg) in patients with cirrhosis (n=5) and in healthy controls (n=5). The plasma clearance of total (bound + unbound) diflunisal was 10.2 ml · min−1 in the control subjects and it was not affected by cirrhosis (10.9 ml · min−1). The plasma protein binding of diflunisal was significantly reduced in cirrhosis; the percentage of unbound diflunisal in plasma was 0.089 in the controls and 0.147 in the patients with cirrhosis. Plasma clearance of unbound diflunisal was significantly impaired in cirrhosis: 11.51 · min−1 in control subjects vs 7.41 · min−1 in cirrhotics. In cirrhotic patients, the unbound partial clearances to the phenolic and acyl glucuronides were both significantly reduced, by approximately 38%. The unbound partial clearance to the sulphate conjugate was not significantly affected by cirrhosis. The results show that both the phenolic and acyl glucuronidation pathways of diflunisal are equally susceptible to the effects of liver cirrhosis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00314852
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Impedance spectroscopy (1992)
    Springer
    Annals of biomedical engineering 20 (1992), S. 289-305 
    Details
    ISSN: 1573-9686
    Schlagwort(e): Impedance ; Immittance ; Complex dielectric constant ; Complex modulus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Technik allgemein
    Notizen: Abstract Impedance spectroscopy (IS) is a general term that subsumes the small-signal measurement of the linear electrical response of a material of interest (including electrode effects) and the subsequent analysis of the response to yield useful information about the physicochemical properties of the system. Analysis is generally carried out in the frequency domain, although measurements are sometimes made in the time domain and then Fourier transformed to the frequency domain. IS is by no means limited to the measurement and analysis of data at the impedance level (e.g., impedance vs. frequency) but may involve any of the four basic immittance levels: thus, most generally, IS stands for immittance spectroscopy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02368532
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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