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  • Springer  (115)
  • Amsterdam : Elsevier
  • 2000-2004  (35)
  • 1990-1994  (81)
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  • 1
    Monograph available for loan
    Monograph available for loan
    EUROPROBE, GeoRift 3 : intraplate tectonics and basin dynamics ; the lithosphere of the southern eastern european craton and its margin (2004)
    Amsterdam : Elsevier
    Associated volumes
    Details Availability
    Call number: ILP/M 06.0353
    In: Publication of the International Lithosphere Programme
    In: Tectonophysics
    Type of Medium: Monograph available for loan
    Pages: vi, 271 S. : Ill., graph. Darst.
    Series Statement: [Publication of the International Lithosphere Programme] 381,1-4 : special issue
    Language: English
    Location: Reading room
    Branch Library: GFZ Library
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis of a swallow homologue from Drosophila pseudoobscura (2000)
    Springer
    Development genes and evolution 210 (2000), S. 157-161 
    Details
    ISSN: 1432-041X
    Keywords: Key words Swallow ; bicoid ; Drosophila ; mRNA localization ; Oogenesis ; Embryogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  We analyzed a functional homologue of the swallow gene from Drosophila pseudoobscura. The swallow gene of D. melanogaster plays an essential role in localizing bicoid mRNA in oocytes, and swallow mutant embryos show anterior pattern defects that result from the lack of localization of the bicoid morphogen. The pseudoobscura homologue rescues the function of swallow mutants when introduced into the genome of D. melanogaster, and its expression is similar to that of the melanogaster gene. The predicted pseudoobscura and melanogaster proteins are 49% identical and 69% conserved. The coiled-coil domain previously identified in the melanogaster swallow protein is strongly conserved in the pseudoobscura homologue, but the weak similarity of the melanogaster swallow protein to the RNP class of RNA-binding proteins is not conserved in the pseudoobscura homologue. These and other observations suggest a structural role for swallow in localizing bicoid mRNA, perhaps as part of the egg cytoskeleton.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004270050023
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  • 3
    Electronic Resource
    Electronic Resource
    Reliability of dipole-dipole electrical resistivity tomography for defining depth to bedrock in covered karst terranes (2000)
    Springer
    Environmental geology 39 (2000), S. 760-766 
    Details
    ISSN: 1432-0495
    Keywords: Key words Karst terranes ; Electrical resistivity tomography ; Sinkholes ; Pinnacles and cutters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  Sinkhole collapse is one of the main limitations on the development of karst areas, especially where bedrock is covered by unconsolidated material. Studies of sinkhole formation have shown that sinkholes are likely to develop in cutter (enlarged joint) zones as a result of subterranean erosion by flowing groundwater. Because of the irregular distribution of pinnacles and cutters on the bedrock surface, uncertainties arise when "hit-or-miss" borehole drilling is used to locate potential collapse sites. A high-resolution geophysical technique capable of depicting the details of the bedrock surface is essential for guiding the drilling program. Dipole-dipole electrical resistivity tomography (ERT) was used to map the bedrock surface at a site in southern Indiana where limestone is covered by about 9 m of clayey soils. Forty-nine transects were conducted over an area of approximately 42,037 m2. The electrode spacing was 3 m. The length of the transects varied from 81 to 249 m. The tomographs were interpreted with the aid of soil borings. The repeatability of ERT was evaluated by comparing the rock surface elevations interpreted from pairs of transects where they crossed each other. The average difference was 2.4 m, with a maximum of 10 m. The discrepancy between interpreted bedrock-surface elevations for a transect intersection may be caused by variations in the subsurface geology normal to the transect. Averaging the elevation data interpreted from different transects improved the ERT results. A bedrock surface map was generated using only the averaged elevation data at the transect junctions. The accuracy of the map was further evaluated using data from four exploratory boreholes. The average difference between interpreted and actual bedrock surface-elevations was less than 0.4 m. The map shows two large troughs in the limestone surface: one coinciding with an existing sinkhole basin, while the other is in alignment with a small topographic valley. Because sinkholes were observed at the same elevation interval in similar valleys in the vicinity, the delineated trough may have implications for future land use at the site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002540050491
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  • 4
    Electronic Resource
    Electronic Resource
    The molecular genetic analysis of haemophilia A; characterization of six partial deletions in the factor VIII gene (1990)
    Springer
    Human genetics 〈Berlin〉 86 (1990), S. 219-227 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In a survey of 528 unrelated haemophilia A patients, six partial deletions of the factor VIII (FVIII) gene were detected by Southern blotting. These deletions were further mapped by a combination of Southern blotting and polymerase chain reaction amplification and found to vary in length between 4.7kb and 57kb. The frequency of detectable FVIII gene deletions (about 1%) is thus considerably lower than previously reported. Statistical analysis of currently available data did not provide any evidence for a deletion “hotspot”. Four of the six deletion patients reported here possessed inhibitors. Taken together with previous data, deletion of the FVIII gene was found to be associated with an approximately fivefold higher risk of developing inhibitors compared with other severe haemophiliacs without gene deletions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00197709
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  • 5
    Electronic Resource
    Electronic Resource
    A comparative study of microsomal and cytosolic S6 phosphatase activities in rat liver (1991)
    Springer
    Molecular and cellular biochemistry 107 (1991), S. 103-110 
    Details
    ISSN: 1573-4919
    Keywords: ribosomal protein ; hepatectomy ; cycloheximide ; insulin ; phosphopeptide mapping ; phosphoprotein phosphatases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary Spontaneous S6 phosphatase activities dephosphorylating Ser(P)-235 and Ser(P)-236 of the ribosomal protein S6 were measured and compared in microsomes and cytosol of rat liver. The substrate used, small (40S) ribosomal subunits 32P-labelled in vitro by protein kinase A, contained phosphorylated S6 (mainly in the dephosphorylated form) and some minor phosphorylated species. The microsomal and cytosolic S6 phosphatase activities displayed a number of distinct properties. The microsomal activity, representing ca 20% of the S6 phosphatase activity in the post-mitochondrial supernatant, was mainly due to a type-1 phosphatase and dephosphorylated only S6. The remaining post-mitochondrial S6 phosphatase activity, which was fully recovered in the cytosol, and appeared to result from a combination of type-1 (43%) and type 2 (57%) phosphatases, acted on S6 as well as on the minor phosphorylated species. The microsomal activity was 50% inhibited by MgCl2 (l0 mM) and was stimulated at least 4.3 fold by MnCl2 (1 mM), while the cytosolic activity was inhibited only 18% by Mg2+ (10 mM) and was increased 2.2 fold by Mn2+ (1 mM). The microsomal activity was increased 10% (P 〈 0.06) by lower doses of insulin (25 U/Kg) and 14% (P 〈 0.05) by vanadate, but was not significantly (P 〉 0.10) affected by larger doses of insulin (100 U/kg), hepatectomy or cycloheximide. By comparison the cytosolic S6 phosphatase activity was unresponsive to insulin and vanadate, but was decreased 14% and 17% (P 〈 0.05) by hepatectomy and cycloheximide. It is concluded that (i) there. are clear differences between the microsomal and cytosolic S6 phosphatase activities, which may be relevant to their specific functions in the cell, and (ii) the inhibition of cytosolic S6 phosphatase activity by hepatectomy and cycloheximide may contribute to the increase in hepatic S6 phosphorylation induced by these treatments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225513
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  • 6
    Electronic Resource
    Electronic Resource
    An AP-1-like motif in the first intron of human Proα1(I) collagen gene is a critical determinant of its transcriptional activity (1992)
    Springer
    Molecular and cellular biochemistry 116 (1992), S. 119-129 
    Details
    ISSN: 1573-4919
    Keywords: collagen transcription ; intronic Ap-1 ; fos jun trans-acting factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The first intron of the human Proα1(I) collagen gene contains an orientation-dependent enhancer composed of both positive and negative cis-acting elements involved in the transcriptional regulation of this gene. Deletion of a 360 bp Sau 3A intronic fragment spanning nucleotide + 494 to + 854 (S360) resulted in dramatic down-regulation of pCOL-KT (Thompson et al., J Biol Chem 266: 2549–2556, 1991). Using a DNaseI protection assay, we demonstrate a single footprint located at + 590 to + 615 in the S360 fragment; nuclear extracts prepared from mesenchymal and nonmesenchymal cells exhibited similar binding characteristics. A double stranded oligonucleotide representing a consensus Ap-1 binding sequence competed with S360 for binding. In contrast to what occurred in response to S360 deletion which was always accompanied by reduced expression, the deletion of the Ap-1 binding site (+ 598 to + 604) caused either increased or decreased expression of the reporter gene depending on the target cell. Site-directed mutations in the Ap-1-like cis-element of Proα1(I) were also tested in transient expression assays. Consistent with the paradoxical results of Ap-1 deletion, we observed that the functional consequences of mutations in the Ap-1 site also varied in different cells. In A204 cells, one point mutation, which resulted in the loss of protein binding to S360, led to increased CAT activity while another point mutant, which retained binding of the Ap-1 like trans-acting factor(s), showed decreased CAT expression. The effects of these two mutations in the HFL-1 cells were exactly opposite of what was seen for A204 cells. Based on these observations, we postulate that the Ap-1 site plays a critical role in the transcriptional activity of the human Proα1(I) gene. The implications of an apparently dual mode of regulation through a single cis-regulatory element are discussed. (Mol Cell Biochem 118: 119–129, 1992)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00299391
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  • 7
    Electronic Resource
    Electronic Resource
    Amphiboles from Dalradian metasedimentary rocks of NE Scotland: Environmental inferences and distinction from amphiboles of meta-igneous amphibolites (1993)
    Springer
    Mineralogy and petrology 49 (1993), S. 45-62 
    Details
    ISSN: 1438-1168
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Zusammenfassung Mehrere Formationen im unteren Teil der Appin Gruppe der Dalradians sind durch karbonatische und kalk-silikatische Lithologien gekennzeichnet. Amphibole treten in diesen metasedimentären Einheiten in verschiedener Ausbildung auf, als feinkörnige, disseminierte Kristalle, als radialstrahlige, die Gesteine durchwachsende Aggregate und in dunkelgrünen, zu mehr als 90% aus Amphibolen bestehenden Lagen. Elektronenstrahl-Mikrosondenuntersuchungen belegen einfache mineralchemische Zusammensetzungen, die Tremolite, tremolitische Hornblende und Magnesio-Hornblende umfaßt. Die einzige bedeutende Substitution ist die zwischen Tremolit und Alumino-Tschermakit [MgSi ⇌ AlviAliv] und zwischen Tremolit und Ferri-Tschermakit [MgSi ⇌ FeviAliv]. Im Gegensatz dazu zeigen Amphibole aus den nahegelegenen Metavulkaniten und intrusiven Metadoleriten vier Substitutionstrends von Tremolit zu Ferro-Akttinolith, Edenit, Alumino-Tschermakit und Ferri-Tschermakit. Diese unterschiedlichen Trends könnten auch anderswo bei der Unterscheidung zwischen Para- und Orthoamphiboliten behilflich sein. Tremolitische Amphibole machen normalerweise einen Großteil der kalk-silikatischen Gesteine aus, in denen ansonsten nur Quarz ± Phologpit auftritt. Karbonate fehlen bemerkenswerterweise. Dies weist auf Mg-reiche sedimentäre Protolithe, wie dolomitische Mergel mit möglicherweise etwas Magnesit, hin. Sedimentologische Überlegungen lassen die Ablagerung in abgeschnürten Küstenlagunen tropischer Breiten, die Teil eines weiträumigen stabilen Schelfes waren, vermuten.
    Notes: Summary Several formations within the lower part of the Dalradian Appin Group are characterised by calcareous and calc-silicate lithologies. Amphibole occurs in these metasedimentary units in a variety of habits, from fine-grained disseminated crystals, through radiating aggregates permeating the whole rock, to dark green layers consisting of over 90% amphibole. Electron microprobe analyses of these amphiboles exhibit simple compositional trends from tremolite, through tremolitic hornblende to magnesio-hornblende. The only significant substitutions are from tremolite towards alumino-tschermakite [MgSi ⇌ AlviAliv] and from tremolite towards ferri-tschermakite [MgSi ⇌ FeviAliv]. This is in marked contrast to amphiboles from nearby suites of metavolcanic rocks and intrusive metadolerites which exhibit four coupled substitutions, leading from tremolite towards the ferro-actinolite, edenite, alumino-tschermakite and ferritschermakite end-members. These distinctive compositional trends may aid the distinction between para- and ortho-amphibolites elsewhere. Tremolitic amphibole commonly constitutes a high proportion of the calc-silicate rocks, the only other phases present being quartz ± phlogopite. Carbonate minerals are notably absent. This suggests that the sedimentary protolith was high in Mg, such as a dolomitic marl, possibly containing some magnesite. Sedimentological considerations suggest deposition in tropical latitudes in restricted coastal lagoons forming part of an extensive stable shelf bordering a mature landscape.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01162925
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  • 8
    Electronic Resource
    Electronic Resource
    Vitamin addition: an option for sustainable activated sludge process effluent quality (2000)
    Springer
    Journal of industrial microbiology and biotechnology 24 (2000), S. 267-274 
    Details
    ISSN: 1476-5535
    Keywords: Keywords: vitamins; activated sludge; industrial wastewater; porous pots; Amtox™
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The process performance and metabolic rates of samples of activated sludge dosed with vitamin supplements have been compared. After initial screening, four vitamins and two metals as single supplements and in pairs, were dosed continuously into the mixed liquor of an activated sludge simulation. Toxicity, oxygen demand removal, respiration rates and suspended solids were measured to monitor the effect on process efficiency. It was confirmed experimentally that an industrial wastewater stream did not contain a sufficient supply of micronutrients for efficient biological treatment. This was concluded from the observation that control sludge batches (receiving no supplements) averaged chemical oxygen demand removal efficiency of 58%. Dosing micronutrients into the mixed liquor produced removal efficiencies of up to 69%. Some of the supplements increased the respiration rate of the sludge while some decreased it, indicating a range of stimulatory and inhibitory effects. Complex interactions between micronutrients that were dosed simultaneously were evident. Several positive effects led to the conclusion that micronutrients have the potential to optimise process performance of activated sludge plants treating industrial wastewater. The addition of phosphorus/niacin and molybdenum/lactoflavin removed wastewater components that were toxic to nitrifiers as indicated through toxicity testing, thus protecting downstream nitrification/denitrification treatment processes. Journal of Industrial Microbiology & Biotechnology (2000) 24, 267–274.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/sj.jim.2900817
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  • 9
    Electronic Resource
    Electronic Resource
    Externally driven countercurrent multiplication in a mathematical model of the urinary concentrating mechanism of the renal inner medulla (1994)
    Springer
    Bulletin of mathematical biology 56 (1994), S. 491-514 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Substitution of measured permeabilities into mathematical models of the concentrating mechanism of the renal inner medulla yields less than the known urine osmolalities. To gain a better understanding of the mechanism we analyse a model in which a force of unspecified origin [expressed as fraction, ɛ, of entering descending thin limb (DTL) concentration] drives fluid from DTL to interstitial vascular space (CORE), thus concentrating the solution in DTL. When flow in the DTL reverses at the hairpin bend of the loop of Henle, the high solute permeability of ascending thin limb (ATL) permits solute to diffuse into the CORE thus permitting ɛ to be multiplied many-fold. Behavior of the model is described by two non-linear differential equations. In the limit for infinite salt permeability of ATL the two equations reduce to a single equation that is formally identical with that for the Hargitay and Kuhn multiplier, which assumes fluid transport directly from DTL to ATL (Z. Electrochem. Angew. Phys. Chem. 55, 539, 1951). Solutions of the equations describing the model with parameters taken from perfused thin limbs show that urine osmolalities of the order of 5000 mosm L−1 can be generated by forces of the order of 20 mosm L−1. It seems probable that mammals including desert rodents use some variant of this basic mechanism for inner medullary concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02460468
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  • 10
    Electronic Resource
    Electronic Resource
    Amphiboles from Dalradian metasedimentary rocks of NE Scotland: environmental inferences and distinction from amphiboles of meta-igneous amphibolites (1994)
    Springer
    Mineralogy and petrology 51 (1994), S. 241-242 
    Details
    ISSN: 1438-1168
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Zusammenfassung Mehrere Formationen im unteren Teil der Appin Gruppe der Dalradians sind durch karbonatische und kalk-silikatische Lithologien gekennzeichnet. Amphibole treten in diesen metasedimentären Einheiten in verschiedener Ausbildung auf, als feinkörnige, disseminierte Kristalle, als radialstrahlige, die Gesteine durchwachsende Aggregate und in dunkelgrünen, zu mehr als 90% aus Amphibolen bestehenden Lagen. Elektronenstrahl-Mikrosondenuntersuchungen belegen einfache mineralchemische Zusammensetzungen, die Tremolite, tremolitische Hornblende und Magnesio-Hornblende umfassen. Die einzige bedeutende Substitution ist die zwischen Tremolit und Alumino-Tschermakit [MgSi ⇌ AlviAliv] und zwischen Tremolit und Ferri-Tschermakit [MgSi = FeviAliv]. Im Gegensatz dazu zeigen Amphibole aus den nahegelegenen Metavulkaniten und intrusiven Metadoleriten vier Substitutionstrends von Tremolit zu Ferro-Aktinolith, Edenit, Alumino-Tschermakit und Ferri-Tschermakit. Diese unterschiedlichen Trends könnten auch anderswo bei der Unterscheidung zwischen Para- und Orthoamphiboliten behilflich sein. Tremolitische Amphibole machen normalerweise einen Großteil der kalk-silikatischen Gesteine aus, in denen ansonsten nur Quarz ± Phlogopit auftritt. Karbonate fehlen bemerkenswerterweise. Dies weist auf Mg-reiche sedimentäre Protolithe, wie dolomitische Mergel mit möglicherweise etwas Magnesit, hin. Sedimentologische Überlegungen lassen die Ablagerung in abgeschnürten Küstenlagunen tropischer Breiten, die Teil eines weiträumigen stabilen Schelfes waren, vermuten.
    Notes: Summary Several formations within the lower part of the Dalradian Appin Group are characterised by calcareous and calc-silicate lithologies. Amphibole occurs in these metasedimentary units in a variety of habits, from fine-grained disseminated crystals, through radiating aggregates permeating the whole rock, to dark green layers consisting of over 90% amphibole. Electron microprobe analyses of these amphiboles exhibit simple compositional trends from tremolite, through tremolitic hornblende to magnesio-hornblende. The only significant substitutions are from tremolite towards alumino-tschermakite [MgSi ⇌ AlviAliv] and from tremolite towards ferri-tschermakite [MgSi ⇌ FeviAliv]. This is in marked contrast to amphiboles from nearby suites of metavolcanic rocks and intrusive metadolerites which exhibit four coupled substitutions, leading from tremolite towards the ferro-actinolite, edenite, alumino-tschermakite and ferritschermakite end-members. These distinctive compositional trends may aid the distinction between para- and ortho-amphibolites elsewhere. Tremolitic amphibole commonly constitutes a high proportion of the calc-silicate rocks, the only other phases present being quartz ± phlogopite. Carbonate minerals are notably absent. This suggests that the sedimentary protolith was high in Mg, such as a dolomitic marl, possibly containing some magnesite. Sedimentological considerations suggest deposition in tropical latitudes in restricted coastal lagoons forming part of an extensive stable shelf bordering a mature landscape.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01159730
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