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Digitale Medien

Male pseudohermaphroditism caused by mutations of testicular 17β–hydroxysteroid dehydrogenase 3 (1994)

Geissler, Wayne M. ; Davis, Daphne L. ; Wu, Ling ; [weitere]

[s.l.] : Nature Publishing Group

Nature genetics 7 (1994), S. 34-39

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ISSN: 1546-1718

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Defects in the conversion of androstenedione to testosterone in the fetal testes by the enzyme 17β–hydroxysteroid dehydrogenase (17β–HSD) give rise to genetic males with female external genitalia. We have used expression cloning to isolate cDNAs encoding a microsomal ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/ng0594-34

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2

Digitale Medien

A novel intercistronic regulatory element of prokaryotic operons (1982)

Higgins, Christopher F. ; Ames, Giovanna Ferro-Luzzi ; Barnes, Wayne M. ; [weitere]

[s.l.] : Nature Publishing Group

Nature 298 (1982), S. 760-762

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] The histidine transport operon of S. typhimurium consists of four cistrons, coordinately transcribed from a single promoter (see accompanying letter4). Between the first two genes of this operon, hisJ (encoding the periplasmic histidine-binding protein) and hisO (encoding a membrane-bound protein), ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/298760a0

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3

Digitale Medien

Plant molecular biology comes of age (1979)

Becker, Wayne M.

[s.l.] : Nature Publishing Group

Nature 280 (1979), S. 719-720

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] PLANT molecular biology is rapidly coming of age, or at least such was the consensus of 160 plant scientists from several dozen countries who attented a recent workshop on Genome Organisation and Expression in Plants. The workshop underscored the number of highly qualified young investigators now ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/280719a0

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4

Digitale Medien

Atom bouncers have it taped (1995)

Itano, Wayne M.

[s.l.] : Nature Publishing Group

Nature 377 (1995), S. 291-292

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] EXPERIMENTERS now have a new set of tricks for manipulating and storing cold atoms — and the key ingredients are familiar high-street commodities. Edward Hinds and co-workers at Yale University have repeatedly bounced rubidium atoms from magnetic tape of the kind used to record audio ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/377291a0

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5

Digitale Medien

Deficits in auditory temporal and spectral resolution in language-impaired children (1997)

Wright, Beverly A. ; Lombardino, Linda J. ; King, Wayne M. ; [weitere]

[s.l.] : Nature Publishing Group

Nature 387 (1997), S. 176-178

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] We measured the detection threshold for a brief tone presented before, during or after two different masking noises in eight children diagnosed with specific language impairment, and in eight control children with normal language skills who matched the others in age and non-verbal intelligence ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/387176a0

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6

Digitale Medien

Surface-mediated alignment of nematic liquid crystals with polarized laser light (1991)

Gibbons, Wayne M. ; Shannon, Paul J. ; Sun, Shao-Tang ; [weitere]

[s.l.] : Nature Publishing Group

Nature 351 (1991), S. 49-50

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] We spin-coated a glass substrate with a thin layer of a silicone polyimide copolymer doped with a diazodiamine dye at a dye: polyimide weight ratio of 1:2. The chemical structure and absorption spectrum of the dye are shown in Fig. 1. We assembled a cell using this coated glass substrate as the top ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/351049a0

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7

Digitale Medien

Odour detection in bees (1993)

Getz, Wayne M.

[s.l.] : Nature Publishing Group

Nature 362 (1993), S. 119-120

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] SIR — Breed and Julian1 argue that data they obtained from controlled agonistic interactions of worker honey-bees "... suggest a system of ordering of priority of cues by the bees. . ." in the context of nestmate discrimination. This interpretation builds on the "hierarchy of importance of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/362119b0

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8

Digitale Medien

Genetic kin recognition: honey bees discriminate between full and half sisters (1983)

Getz, Wayne M. ; Smith, Katherine B.

[s.l.] : Nature Publishing Group

Nature 302 (1983), S. 147-148

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] Queen honey bees mate with a number of different drones before they lay their first eggs11. The sperm, to some extent, mix in the spermatheca and the hive contains several distinct patrilineal worker groups of full sisters while the workers are matrilineal half sisters across groups12'13. In ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/302147a0

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9

Digitale Medien

MHC class I alloantigen specificity of Ly-49 + IL-2-activated natural killer cells (1992)

Karlhofer, Franz M. ; Ribaudo, Randall K. ; Yokoyama, Wayne M.

[s.l.] : Nature Publishing Group

Nature 358 (1992), S. 66-70

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] As Ly-49 seems to be encoded by a multigene family12 in the mouse NK complex13, we have speculated that Ly-49 may be representative of a family of NK cell surface molecules that recognize polymorphic ligands14. To address this possibility, we prepared Ly-49+ and Ly-49~ effector cells and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/358066a0

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10

Unbekannt

Cowpox virus encodes a protein that binds B7.1 and B7.2 and subverts T cell costimulation (2019)

Wang, Xiaoli ; Piersma, Sytse J. ; Elliott, Jabari I. ; [weitere]

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2019; 116(42): 21113-21119. Published 2019 Oct 01. doi: 10.1073/pnas.1909414116.

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Publikationsdatum: 2019-10-01

Beschreibung: Costimulation is required for optimal T cell activation, yet it is unclear whether poxviruses dedicatedly subvert costimulation during infection. Here, we report that the secreted M2 protein encoded by cowpox virus (CPXV) specifically interacts with human and murine B7.1 (CD80) and B7.2 (CD86). We also show that M2 competes with CD28 and CTLA4 for binding to cell surface B7 ligands, with stronger efficacy against CD28. Functionally, recombinant M2 and culture supernatants from wild-type (WT) but not M2-deficient (∆M2) CPXV-infected cells can potently suppress B7 ligand-mediated T cell proliferation and interleukin-2 (IL-2) production. Furthermore, we observed increased antiviral CD4 and CD8 T cell responses in C57BL/6 mice challenged by ∆M2 CPXV compared with WT virus. These differences in immune responses to ∆M2 and WT CPXV were not observed in CD28-deficient mice. Taken together, our findings define a mechanism of viral sabotage of T cell activation that highlights the role of CD28 costimulation in host defense against poxvirus infections.

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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