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  • 1
    Monograph available for loan
    Monograph available for loan
    Der neue Kosmos (1991)
    Berlin [u.a.] : Springer
    Details Availability
    Call number: M 93.0649
    Type of Medium: Monograph available for loan
    Pages: XVIII, 448 S.
    Edition: 5., überarb. und erw. Aufl.
    ISBN: 3540537570
    Uniform Title: The new cosmos
    Classification:
    Astronomy and Astrophysics
    Language: German
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 2
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    Unknown
    On the Contours of Narrow Absorption Lines (1932)
    Institute of Physics
    Details
    Publication Date: 1932-03-01
    Print ISSN: 0004-637X
    Electronic ISSN: 1538-4357
    Topics: Physics
    Published by Institute of Physics
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    PAPER CURRENT
  • 3
    Electronic Resource
    Electronic Resource
    Über die kosmische Häufigkeit des H2-Isotopes (1932)
    Springer
    Naturwissenschaften 20 (1932), S. 936-937 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01504707
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  • 4
    Electronic Resource
    Electronic Resource
    X-Ray- and catheter-guided intracardial laser photocoagulation of arrhythmogenic substrates (1991)
    Springer
    Lasers in medical science 6 (1991), S. 367-370 
    Details
    ISSN: 1435-604X
    Keywords: Arrhythmia ; Cardiology ; Cardiovascular surgery ; Catheter ; Heart ; Laser ; Mapping ; Photocoagulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract Cardiac arrhythmias resistant to drug treatment and correlated to an arrhythmogenic anatomic structure can be treated in several cases by surgical intervention. A further method of treatment is the percutaneous, ECG mapping-guided catheter ablation with either direct current (DC) or radio frequency (RF) ablation of localized arrhythmogenic foci. These methods overcome some complications inherent to open surgery to the heart; DC ablation, however, often induces further arrhythmias or ventricular or auricular fibrillation, while RF ablation shows only little success. In the method presented here disturbing electric effects are avoided by laser photocoagulation via a transcatheter quartz fibre. An electrode/laser catheter recently developed simultaneously allows for a mapping-guided localization of arrhythmogenic substrates and their percutaneous transluminal and intracardial deactivation. An anchoring mechanism at the catheter's tip keeps it in place during the treatment. This mechanism also prevents contact of the quartz fibre to the endomyocardium in order to avoid destruction of the fibre tip due to local overheating of the myocardium. A Nd-YAG laser (wavelength 1.064μm) delivers pulses of 5–10 s and a power of 10–15 W at the tip of a quartz fibre with a core diameter of 400μm. The corresponding parameter or irradiation of the myocardium are power densities of 700–1500 W cm−2 and energy densities of 8–15 kJ cm−2. In dog hearts lesions 2–10 mm in diameter and up to 11 mm in depth were obtained. Simultaneously registered electrocardiograms show that primarily induced arrhythmias lasted only for about 3 min but could not again be observed during the 2–3 months follow-up. Crater formation or perforation of the myocardium always could be avoided by an ECG-controlled laser irradiation. This indicates the safety and efficacy of the laser method for intracardial intervention in arrhythmogenic substrates. Clinical tests have been started recently.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02030895
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  • 5
    Electronic Resource
    Electronic Resource
    Laser-assisted fluorescence detection of plaque (1991)
    Springer
    Lasers in medical science 6 (1991), S. 289-296 
    Details
    ISSN: 1435-604X
    Keywords: Atherosclerosis ; Dihaematoporphyrin ether/ester, DHE ; Haematoporphyrin derivative, HPD ; Laser angioplasty ; Laser-induced fluorescence ; Plaque
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract Selective fluorescence-marking of plaque offers new possibilities in cardiovascular diagnosis and therapy. Angioscopic investigations and spectrometry-assisted laser angioplasty will be simplified and more effective as compared with methods of today. It might help to make laser angioplasty a further promising interventional method to overcome, at least partially, the problems caused by atheromatous or atherosclerotic changes in the cardiovascular system. Fluorescence detection and imaging of markers is usually limited by the intrinsic fluorescence of tissue. Optical differential methods in combination with two-wavelength laser excitation and computer-assisted image processing, however, allow for discrimination of background-related signals and enable plaque detection and imaging at a high contrast. Plaque consists of either fibrotic, lipoid, or calcified depositions and is rather bradytrophic. For that reason in vitro experiments on human specimens post mortem seem to be justified and of clinical evidence. Due to intrinsically different fluorometric properties of plaque and normal vascular tissue imaging of marker-free plaque areas is possible. Additionally the specimens have been incubated with a haematoporphyrin-containing fluorescence marker at concentrations of 10–40μg ml−1 and incubation times of 60 min in order to obtain a corresponding increase in contrast. Lipoid depositions show the highest contrast because of lipophilic properties of the marker, while fibrotic and calcified plaque is slightly less effectively marked. The results, however, so far obtained indicate that fluorescence detection of plaque promises further progress in diagnosis and therapy of cardiovascular diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02030882
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  • 6
    Electronic Resource
    Electronic Resource
    Fluorescence detection and photodynamic treatment of photosensitized tumours in special consideration of urology (1990)
    Springer
    Lasers in medical science 5 (1990), S. 207-212 
    Details
    ISSN: 1435-604X
    Keywords: Bladder tumour ; Diagnosis ; Fluorescence ; Photodynamic therapy ; Photosensitization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract Most methods of modern laser tumour therapy are physically based on the conversion of light to heat. Recently tumours have also been treated using ionizing processes for tissue ablation. Photodynamic laser therapy (PDT), however, involves light-induced non-thermal biochemical processes and the use of a photosensitizer. Several drugs are known to be stored selectively in tumours after systemic application. This transient marking can be used for diagnostic and therapeutic procedures. The marker most commonly used is dihaematoporphyrin ether/ester (DHE) intravenously injected at doses of 0.2–3.0 mg/kg bodyweight for diagnosis and therapy, respectively. The corresponding clearance intervals after injection of DHE range from 3–48 h to 25–75 h. Detection of photosensitized tumours might offer great advantages. The highly sensitive two-wavelength laser excitation method with computerized fluorescence imaging recently has been transferred to the hospital for clinical tests. Photoinduced production of singlet oxygen is claimed to be the initial process which leads to later tumour destruction and therapy. PDT has been applied to 20 patients suffering from superficial tumours (TIS GII–III) recurred after application of other treatments. The results after PDT were evaluated by three-monthly check-ups (endoscopy, cytology, bladder mapping, renal ultrasonography) as well as by computed tomography (CT) examination at 8–13 month intervals. In six patients treated by PDT no tumour recurrence has been found over the whole observation period of up to 5 years. Four patients have remained free of tumour (12 and 14 months) after repeated transurethral resection (TUR) and Nd-YAG laser therapy following PDT. Due to an initial application of insufficient irradiation four patients required a second PDT. In one patient a circumscribed dysplasia appeared at the left ostium 26 months following PDT and was treated successfully by means of thermal Nd-YAG laser irradiation following TUR. In six patients slight mucosal atypia persisted for a period of at least 2.5 years. One cystectomy had to be performed because of bladder shrinkage. The dissected bladder, however, was free of tumour. These preliminary results suggest that PDT is justified in patients who are in a worst-case situation with cystectomy recommended in case of recurrent superficial TIS bladder carcinoma and indicate the future potential of photodynamic therapy of tumours. Homogeneous irradiation of the area to be treated and a reliable light dosimetry are prerequisites for an effective tumour therapy. Standard instruments for a routine application do not exist, but are under development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02031384
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  • 7
    Electronic Resource
    Electronic Resource
    Über die Balmerserie des Wasserstoffs im Sonnenspektrum (1930)
    Springer
    The European physical journal 59 (1930), S. 353-377 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Zusammenfassung Mit Hilfe des Registrierphotometers kann die Balmerserie im Sonnenspektrum bis zur 14. Linie verfolgt werden. Bei den ersten Linien ist die Breite noch durch Strahlungsdämpfung mitbedingt, die höheren Serienglieder dagegen sind durch Druck- (Stark-) Effekt verbreitert. Mit Hilfe der quantentheoretisch berechneten Übergangswahrscheinlichkeiten läßt sich die Anzahl zweiquantiger Wasserstoff atome in der umkehrenden Schicht der Sonne ermitteln. Anschließend werden einige Bemerkungen über die Form der Linien mitgeteilt. Berechnet man unter der Annahme thermischen Gleichgewichts die Gesamtzahl der Wasserstoffatome in der Sonnenatmosphäre, so findet man, daß an der Basis dieser Atmosphäre ein Druck von ∼1 Atm. bestehen müßte. Dies ist mit anderen Beobachtungen nicht vereinbar. Es bestehen also in der Sonne Abweichungen vom thermischen Gleichgewicht, wie sie Adams und Russell in Sternen beobachtet haben. Diese werden näher diskutiert. Zum Schluß werden noch einige Beobachtungen der Wasserstofflinien im Spektrum der Chromosphäre, des Sonnenrandes und ruhender Protuberanzen mitgeteilt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01339909
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  • 8
    Electronic Resource
    Electronic Resource
    Quantitative and comparative study of haematoporphyrin-derived photosensitizers on a murine tumour model (1990)
    Springer
    Lasers in medical science 5 (1990), S. 309-316 
    Details
    ISSN: 1435-604X
    Keywords: Photodynamic therapy ; PDT ; Fluorescence ; Haematoporphyrin derivative ; HPD ; Diagnosis ; Murine tumour ; Laser ; Pharmacodynamic ; Pharmacokinetic ; Regrowth delay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract Eight commercially available HPD-photosensitizers intended for photodynamic therapy were tested in a murine tumour model with regard to their therapeutic efficacy. The regrowth delay of the fibrosarcoma SSK-2 on the mouse C3H, Neuherberg-line, was determined 3, 24, 48 and 72 h after injection of the drugs (dose: 9 mg kg−1 body weight). The corresponding pharmacodynamics, as measured by regrowth delay, were approximated by an exponential function and the characterizing coefficients derived. These coefficients served to quantify the photodynamic properties of the drugs. The pharmacodynamics of five substances were compared with those obtained fluorometrically. The latter showed shorter decay constants than the therapy-correlated substances which indicates different metabolic behaviour of the therapeutic and diagnostically useful fluorescent components of haematoporphyrin-derived photosensitizers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032660
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