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  • Springer  (83)
  • Wiley-Blackwell  (13)
  • American Meteorological Society (AMS)
  • 1990-1994  (82)
  • 1965-1969  (14)
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  • 1
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We present a highly sensitive method that has been applied to map the chromosomal origin of the prominent cell surface antigen of Ewing's tumor cells recognized by monoclonal antibody HBA-71. The technique allows an unambiguous identification of human chromosomal material in interspecific cell hybrids. This is achieved by fluorescent in situ hybridization of biotinylated total human DNA, followed by high resolution fluorescence banding with the chromomycin/distamycin/ DAPI triple stain. An advantage of this method is that all signals can be visualized in one single operation by simply switching the appropriate filter blocks. The protocol has proved extremely useful in gene mapping by means of interspecific cell hybrids, a technique that depends on the accurate and unambiguous recognition of the relevant (e.g., human) genetic material in the clonal genome. Our studies confirm that this antigen is the product of the MIC2 gene, which is so far the only well-studied pseudoautosomal gene in man, and which is located on the short arms of chromosomes X and Y. Furthermore, no influence of the Ewing's tumor-specific translocation t(11;22) on MIC2 expression could be discerned.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of microbiology 153 (1990), S. 146-150 
    ISSN: 1432-072X
    Keywords: Alcaligenes spec. GL ; Phosphonate metabolism ; Glyphosate ; Sarcosine ; Phosphate starvation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Alcaligenes spec. strain GL (IMET 11314) is able to grow on glyphosate (N-[phosphonomethyl]glycine) and other phosphonates as sole source of phosphorus. Degradation of glyphosate to inorganic phosphate and sarcosine by this strain is subject to several regulatory principles. While uptake and dephosphonation of glyphosate are regulated by Pi starvation, the intensity of glyphosate degradation is also controlled by the cellular ability to utilize the C-skeleton derived from glyphosate. Depending on the external concentration of glyphosate, the liberated sarcosine is differentially metabolised. Utilization of the sarcosine moiety and complete incorporation of 3-[14C]-label of glyphosate into cellular material occur only in cultures adapted to higher concentrations (5 mM) of the herbicide. At low concentrations of glyphosate (1 mM) only the Pi required by the growing cultures is utilized but not the sarcosine. Initially high rates of glyphosate uptake obtained after Pi-starvation decrease in the presence of low glyphosate concentrations. It is suggested that uptake and metabolism of glyphosate are connected with the expression of the sarcosine metabolizing capacity of the Alcaligenes cells.
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  • 3
    ISSN: 1432-0630
    Keywords: 68.55 ; 68.65 ; 78.65
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Mo/Si multilayers are fabricated by electron-beam evaporation in UHV at different temperatures (30° C, 150° C, 200° C) during deposition. After completion their thermal stability is tested by baking them at temperatures (T bak) between 200° C and 800° C in steps of 50° C or 100° C. After each baking step the multilayers are characterized by small angle CuKα-X-ray diffraction. Additionally, the normal incidence soft-X-ray reflectivity for wavelengths between 11 nm and 19 nm is determined after baking at 500° C. Furthermore, the layer structure of the multilayers is investigated by means of Rutherford Backscattering Spectroscopy (RBS) and sputter/Auger Electron Spectroscopy (AES) technique. While the reflectivity turns out to be highest for a deposition temperature of 150° C, the thermal stability of the multilayer increases with deposition temperature. The multilayer deposited at 200° C stands even a 20 min 500° C baking without considerable changes in the reflectivity behaviour.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1041
    Keywords: ibuprofen ; rheumatoid arthritis ; enantiomer ; stereoselectivity ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary S(+)-, R(−)- or racemic ibuprofen was administered orally to volunteers in doses of 150 mg, 300 mg and 500 mg pure S(+)-, 300 mg pure R(−)- and 600 mg racemic ibuprofen. The pharmacokinetic parameters in humans showed that S(+)-ibuprofen was not inverted to R(−)-ibuprofen, whereas R(−)-ibuprofen was inverted to S(+)-ibuprofen to a variable degree. S(+)-ibuprofen and R(−)-ibuprofen given alone more rapidly reached significantly higher maximal plasma concentrations than after the same doses of the racemic compound. The elimination half-lives and clearance values for all three forms of ibuprofen were comparable. The mean residence time of S(+)-ibuprofen after R(−)- and racemic ibuprofen was significantly longer than after administration of the pure S(+)-enantiomer. Judged by the AUC, the bioavailability of S(+)-ibuprofen was independent of the dose within the range tested. Administration of S(+)-ibuprofen to 6 rheumatic patients showed that the pharmacokinetic behaviour of S(+)-ibuprofen in patients was similar to that found in volunteers. S(+)-ibuprofen proved to be an effective analgesic antirheumatic drug in the dose range 1 to 1.5 g/day.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1435-1536
    Keywords: Light-scattering ; flowing polymer solution ; dilute polymer solution ; orientation and deformation of macromolecules ; polystyrene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract We describe the behavior of dilute polymer solutions by means of light-scattering under shear flow. Solution properties of polystyrene in benzene over a wide range of molecular weight has been studied to determine the coefficientsa andK of the Mark-Houwink relationship and to estimate the rheological conditions with regard to light-scattering experiments of flowing polymer solutions. The investigations were carried out to measure the shear-rate dependence of macromolecules in solution, e.g., to observe an orientation and changing of the mean-square radius of gyration.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    International journal of earth sciences 59 (1969), S. 228-256 
    ISSN: 1437-3262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract An area of about 200 sq.m., consisting of epimetamorphic Precambrian schists and granites in the northern parts of the Tibesti mountains was studied by geologic interpretation of small scale aerial photographs. The scope of work was the evaluation of the structural trends in the basement complex, the distribution of lengths and azimuts of the fracture pattern, and a quantitative asessment of the drainage system. Plotting of the photogeologic and drainage map was done by a third order instrument, the ZEISS Stereotop. The network of pass points used in stereoplotting was established by slotted templet radial triangulation at a scale of 1∶50000. Fracture trace analysis showed that the fracture pattern is not related to the fold structures of the bedrock, but to a younger wrench fault system with a master shear direction of 30°. The drainage network is mature in spite of only episodic rainfalls. 15 drainage basins of 3rd to 5th order magnitude were examined closely, and channel orders, numbers and lengths as well as basin areas were determined.Horton's law of stream numbers is observed closely by all basins in spite of obvious structural control. The weighted mean bifurcation ratio is fairly constant around the value of 4.10. Mean channel lengths seem to be more sensitive to structural control, as deviations of measurements fromHorton's second law are noticeable in many basins. Drainage densities are closely grouped around a mean value of 3.53. The relation between drainage density and channel frequency found byMelton is maintained, but the values tend to be somewhat lower than described originally. Influence of fracture directions on the drainage pattern is obvious in the distribution of azimuts. ASpearman rank correlation test showed significant control of the drainage network by the directions of the fracture system. The use of aerial photographs in quantitative evaluations of fracture and drainage patterns may, in many cases, result in the procurement of more accurate data in much shorter time than by conventional methods.
    Abstract: Résumé L'interprétation photogéologique d'une région de schistes précambriens épimétamorphiques d'environ 500 km2 au versant nord du Tibesti a été effectuée en vue d'une étude quantitative des grandes structures et des réseaux de fractures et de drainage. L'analyse statistique des fractures a prouvé que les directions dominantes du réseau de fractures ne sont pas liées au plissement mais à un «wrench fault system» au sens deMoody &Hill (1956). On a pu détérminer l'ordre, le nombre et les longueurs des segments de drainage ainsi que la surface des bassins du réseau de drainage, bien développé malgré les pluies rares mais intenses. Le contrôle structural du réseau de drainage présente un écart relativement faible de la 1ère loi deHorton. Le système de drainage s'accorde toutefois moins bien à la 2e loi deHorton, manifestement plus sensitive. Sur un sous-sol uniforme au point de vue lithologique, le rapport de bifurcation est assez constant autour de la valeur moyenne Rh=4.10. La relation entre la densité du réseau de drainage et la fréquence des segments découverte parMelton (1958) s'est confirmée. La comparaison des directions des réseaux de fractures et de drainage démontre nettement l'influence, prouvée par un test de corrélationSpearman, des directions tectoniques sur le système de drainage. L'analyse photogéologique de photographies aériennes permet une étude quantitative de réseux de fractures et de drainage en moins de temps et avec une précision souvent supérieure aux mesures faites sur des cartes ou sur le terrain.
    Notes: Zusammenfassung In einem Bereich präkambrischer epizonal metamorpher Schiefer von rund 500 km2 am Nordabfall des Tibestigebirges wurde eine photogeologische Untersuchung durchgeführt, um neben den Großstrukturen das Kluftnetz und das Entwässerungsnetz möglichst quantitativ zu erfassen. Die statistische Kluftanalyse ergab, daß die vorherrschenden Richtungen des Kluftnetzes genetisch nicht mit dem Faltenbau in Verbindung gebracht werden können, sondern an ein „wrench fault system“ im Sinne vonMoody &Hill (1956) gebunden sind. An dem voll entwickelten Entwässerungsnetz von Trockentälern, die nur während der episodischen, aber intensiven Regenfälle Wasser führen, wurden die Ordnungen, Anzahlen und Längen der Talsegmente sowie die Fläche der einzelnen Entwässerungsbecken bestimmt. Die bei struktureller Kontrolle des Entwässerungsnetzes zu erwartenden Abweichungen vonHorton's 1. Gesetz sind verhältnismäßig gering. Das Talsystem folgt jedoch dem offenbar sensitiveren 2.Horton'schen Gesetz wesentlich schlechter. Bei lithologisch gleichmäßigem Untergrund liegt das mittlere Bifurkationsverhältnis recht konstant um den Wert Rb=4,10. Der vonMelton (1958) gefundene gesetzmäßige Zusammenhang zwischen Entwässerungsdichte und Talsegment-Häufigkeit konnte bestätigt werden. Ein Vergleich der Richtungsverteilungen von Kluft- und Talnetz erweist die deutliche Beeinflussung des Entwässerungssystems durch die tektonischen Richtungen; einSpearman-Rangkorrelationstest ergibt für die Mehrzahl der Bekken bei einem Signifikanzniveau von α=0,100 eine signifikante Beeinflussung des Entwässerungsnetzes durch die Kluftrichtungen. Für quantitative Untersuchungen über Kluftnetz und Entwässerungsnetz bietet die photogeologische Auswertung von Luftbildern nicht nur Vorteile im Zeit- und Arbeitsaufwand, sondern teilweise auch höhere Genauigkeit gegenüber Messungen aus Karten oder im Gelände.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 212 (1968), S. 83-103 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Within the framework of the hydrodynamic model the exact coupling constants of the coupling of the giant multipole resonances to the surface quadrupole oscillations of nuclei are derived. The differences to former variational calculations are discussed. It is found that the coupling constants for the terms linear in the surface variables are almost the same whereas the coupling constants for the quadratic terms differ appreciably. The influence on the photon absorption and scattering cross sections of spherical nuclei is discussed.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Chromatographia 39 (1994), S. 375-375 
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Chromatographia 39 (1994), S. 389-390 
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Chromatographia 39 (1994), S. 129-129 
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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