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  • GEOPHYSICS  (1,591)
  • Animals  (1,183)
  • 1990-1994  (1,300)
  • 1980-1984  (1,474)
  • 1
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    Cloned viral protein vaccine for foot-and-mouth disease: responses in cattle and swine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-04
    Description: A DNA sequence coding for the immunogenic capsid protein VP3 of foot-and-mouth disease virus A12, prepared from the virion RNA, was ligated to a plasmid designed to express a chimeric protein from the Escherichia coli tryptophan promoter-operator system. When Escherichia coli transformed with this plasmid was grown in tryptophan-depleted media, approximately 17 percent of the total cellular protein was found to be an insoluble and stable chimeric protein. The purified chimeric protein competed equally on a molar basis with VP3 for specific antibodies to foot-and-mouth disease virus. When inoculated into six cattle and two swine, this protein elicited high levels of neutralizing antibody and protection against challenge with foot-and-mouth disease virus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kleid, D G -- Yansura, D -- Small, B -- Dowbenko, D -- Moore, D M -- Grubman, M J -- McKercher, P D -- Morgan, D O -- Robertson, B H -- Bachrach, H L -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1125-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272395" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antibody Formation ; Base Sequence ; Cattle ; Cattle Diseases/*prevention & control ; *Cloning, Molecular ; DNA Restriction Enzymes ; DNA, Recombinant/metabolism ; Foot-and-Mouth Disease/*prevention & control ; Immunity, Cellular ; Protein Biosynthesis ; Swine ; Swine Diseases/*prevention & control ; Transcription, Genetic ; *Vaccines ; Viral Proteins/genetics/*therapeutic use
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Landau damping of auroral hiss (1994)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: Auroral hiss is observed to propagate over distances comparable to an Earth radius from its source in the auroral oval. The role of Landau damping is investigated for upward propagating auroral hiss. By using a ray tracing code and a simplified model of the distribution function, the effect of Landau damping is calculated for auroral hiss propagation through the environment around the auroral oval. Landau damping is found to be the likely mechanism for explaining some of the one-sided auroral hiss funnels observed by Dynamics Explorer 1. It is also found that Landau damping puts a lower limit on the wavelength of auroral hiss. Poleward of the auroral oval, Landau damping is found in a typical case to limit omega/k(sub parallel) to values of 3.4 x 10(exp 4) km/s or greater, corresponding to resonance energies of 3.2 keV or greater and wavelengths of 2 km or greater. For equatorward propagation, omega/k(sub parallel) is limited to values greater than 6.8 x 10(exp 4) km/s, corresponding to resonance energies greater than 13 keV and wavelengths greater than 3 km. Independent estimates based on measured ratios of the magnetic to electric field intensity also show that omega/k(sub parallel) corresponds to resonance energies greater than 1 keV and wavelengths greater than 1 km. These results lead to the difficulty that upgoing electron beams sufficiently energetic to directly generate auroral hiss of the inferred wavelength are not usually observed. A partial transmission mechanism utilizing density discontinuities oblique to the magnetic field is proposed for converting auroral hiss to wavelengths long enough to avoid damping of the wave over long distances. Numerous reflections of the wave in an upwardly flared density cavity could convert waves to significantly increased wavelengths and resonance velocities.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 99; A2; p. 2471-2488
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  • 3
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    Giant panda paternity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, S J -- Goldman, D -- Knight, J -- Moore, H D -- Wildt, D E -- Bush, M -- Montali, R J -- Kleiman, D -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1127-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701515" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carnivora ; Male ; *Paternity ; Polymorphism, Genetic ; Proteins/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    The Koshak section: Evidence for element fractionation and an oxidation event at the K/T boundary (1993)
    In:  Other Sources
    Details
    Publication Date: 2019-01-25
    Description: The Koshak site is a new K/T section located about 125 km EEN of the Fort Shevchenko city, Mangyshlak, Kazakhstan. In this paper, we report results of geochemical and mineralogical studies of this section which indicate a deep element fractionation and an oxidation event at the K/T boundary.
    Keywords: GEOPHYSICS
    Type: Lunar and Planetary Inst., Twenty-Fourth Lunar and Planetary Science Conference. Part 3: N-Z; p 1051-1052
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  • 5
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    Correlated dynamical changes in the near-earth and distant magnetotail regions - ISEE 3 (1984)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: It is pointed out that the redeployment of ISEE 3 from its continuous monitoring of the solar wind in a large orbit about the upstream Lagrangian point to an extended magnetotail orbit has afforded an opportunity for deep-tail passage of October 1982, and in the radial range from 200 to 220 R(E) during the near-apogee part of the second tail passage in January-February 1983. Attention is given to instrumentation and data sets, spacecraft positions, and observational data.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 89; 3855-386
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  • 6
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    Zonal mean winds in the equatorial mesosphere and lower thermosphere observed by the High Resolution Doppler Imager (1993)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: This paper presents analyses of mesospheric and lower thermospheric zonal mean winds observed by the High Resolution Doppler Imager (HRDI) on the Upper Atmosphere Research Satellite (UARS). Monthly averages of the equatorial zonal mean zonal winds are presented for January 1992 through June 1993. Equatorial zonal winds in the 70-90 km region are dominated by a semiannual oscillation (SAO), ranging from 30 m/s (westerly) to -100 m/s (easterly). At high latitudes the zonal wind variations are predominantly annual. Above 90 km, the low-latitude flow is easterly at all times, punctuated by a small semiannual variation. This behavior may be related to the deposition of momentum by the diurnal tides.
    Keywords: GEOPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 20; 24; p. 2849-2852
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  • 7
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    Correlated low-frequency electric and magnetic noise along the auroral field lines (1984)
    In:  Other Sources
    Details
    Publication Date: 2019-08-13
    Description: Dynamics Explorer 1 measurements of intense low-frequency electric and magnetic noise observed at low altitudes over the auroral zone are described. The intensity of both the electric and magnetic fields decreases rapidly with increasing frequency. Most of the energy is at frequencies below the O(+) cyclotron frequency, and some evidence is found for a cutoff or change in spectral slope near that frequency. The magnetic to electric field ratio decreases rapidly with increasing radial distance and also decreases with increasing frequency. The polarization of the electric field in a plane perpendicular to the earth's magnetic field is essentially random. The transverse electric and magnetic fields are closely correlated, with the average Poynting flux directed toward the earth. The total electromagnetic power flow associated with the noise is substantial. Two general models are discussed to interpret these observations, one based on static electric and magnetic fields imbedded in the ionosphere and the other based on Alfven waves propagating along the auroral field lines.
    Keywords: GEOPHYSICS
    Type: AD-A150627 , Journal of Geophysical Research (ISSN 0148-0227); 89; 8971-898
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  • 8
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    Remote sensing of mesospheric winds with the High-Resolution Doppler Imager (1992)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: Observations of the winds in the upper atmosphere obtained with the High-Resolution Doppler Imager (HRDI) on the Upper Atmosphere Research Satellite (UARS) are discussed. This instrument is a very stable high-resolution triple-etalon Fabry-Perot interferometer, which is used to observe the slight Doppler shifts of absorption and emission lines in the O2 Atmospheric bands induced by atmospheric motions. Preliminary observations indicate that the winds in the mesosphere and lower thermosphere are a mixture of migrating and non-migrating tides, and planetary-scale waves. The mean meridional winds are dominated by the 1,1 diurnal tide which is easily extracted from the daily zonal means of the satellite observations. The daily mean zonal winds are a mixture of the diurnal tide and a zonal flow which is consistent with theoretical expectations.
    Keywords: GEOPHYSICS
    Type: Planetary and Space Science (ISSN 0032-0633); 40; 12; p. 1599-1606.
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  • 9
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    A new redox cofactor in eukaryotic enzymes: 6-hydroxydopa at the active site of bovine serum amine oxidase (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-05-25
    Description: An active site, cofactor-containing peptide has been obtained in high yield from bovine serum amine oxidase. Sequencing of this pentapeptide indicates: Leu-Asn-X-Asp-Tyr. Analysis of the peptide by mass spectrometry, ultraviolet-visible spectroscopy, and proton nuclear magnetic resonance leads to the identification of X as 6-hydroxydopa. This result indicates that, contrary to previous proposals, pyrroloquinoline quinone is not the active site cofactor in mammalian copper amine oxidases. Although 6-hydroxydopa has been implicated in neurotoxicity, the data presented suggest that this compound has a functional role at an enzyme active site.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Janes, S M -- Mu, D -- Wemmer, D -- Smith, A J -- Kaur, S -- Maltby, D -- Burlingame, A L -- Klinman, J P -- GM 39296/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1990 May 25;248(4958):981-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of California, Berkeley 94720.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2111581" target="_blank"〉PubMed〈/a〉
    Keywords: *Amine Oxidase (Copper-Containing) ; Amino Acid Sequence ; Animals ; Binding Sites ; Cattle ; Copper ; Dihydroxyphenylalanine/*analogs & derivatives/metabolism ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Molecular Sequence Data ; Oxidoreductases/metabolism ; Oxidoreductases Acting on CH-NH Group Donors/blood/*metabolism ; Peptide Fragments/analysis/chemical synthesis ; Quinones/metabolism ; Spectrophotometry, Ultraviolet
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Human immunodeficiency virus infection of human-PBL-SCID mice (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-02-15
    Description: Severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID mice) have inducible human immune function and may be useful as a small animal model for acquired immunodeficiency syndrome (AIDS) research. Hu-PBL-SCID mice infected with human immunodeficiency virus-1 (HIV-1) contained virus that was recoverable by culture from the peritoneal cavity, spleen, peripheral blood, and lymph nodes for up to 16 weeks after infection; viral sequences were also detected by in situ hybridization and by amplification with the polymerase chain reaction (PCR). Mice could be infected with multiple strains of HIV-1, including LAV-1/Bru, IIIB, MN, SF2, and SF13. HIV-1 infection affected the concentration of human immunoglobulin and the number of CD4+ T cells in the mice. These results support the use of the hu-PBL-SCID mouse for studies of the pathogenesis and treatment of AIDS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mosier, D E -- Gulizia, R J -- Baird, S M -- Wilson, D B -- Spector, D H -- Spector, S A -- AI-27703/AI/NIAID NIH HHS/ -- AI-29182/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1991 Feb 15;251(4995):791-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Immunology, Medical Biology Institute, La Jolla, CA 92037.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1990441" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Transfusion ; Chimera/*immunology ; *Disease Models, Animal ; *HIV Infections/immunology ; *HIV-1/isolation & purification ; Humans ; Immunologic Deficiency Syndromes/genetics/*immunology ; Lymphocyte Transfusion ; Mice ; Mice, Mutant Strains/*immunology ; Spleen/microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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