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  • 2005-2009  (56)
  • 1990-1994  (45)
  • 1985-1989  (28)
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  • 1
    Electronic Resource
    Electronic Resource
    Geographical distribution of haplotypes in Swedish families with Huntington's disease (1994)
    Springer
    Human genetics 〈Berlin〉 94 (1994), S. 124-128 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract This study was planned to determine the number of origins of the mutation underlying Huntington's disease (HD) in Sweden. Haplotypes were constructed for 23 different HD families, using six different polymorphisms [(CCG) n , GT70, 674, BS1, E2 and 4.2], including two within the gene. In addition, extensive genealogical investigations were performed, and the geographical origin of the haplotypes was studied. Ten different haplotypes were observed suggesting multiple origins for the HD mutation in Sweden. Analysis of the two polymorphic markers within the HD gene (the CCG repeat and GT70) indicates that there are at least three origins for the HD mutation in Sweden. One of these haplotypes (7/A) accounts for 89% of the families, suggesting that the majority of the Swedish HD families are related through a single HD mutation of ancient origin. Furthermore, three of the families that were previously considered to be unrelated could be traced to a common ancestor in the 15th century, a finding that is consistent with this hypothesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202856
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  • 2
    Electronic Resource
    Electronic Resource
    Genetic and blood coagulation characterization of “Swedish” families with von Willebrand's disease types I and III: New aspects of heredity (1992)
    Springer
    Human genetics 〈Berlin〉 89 (1992), S. 147-154 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Twenty-five patients with von Willebrand's disease (vWD) type III were analysed with regard to blood coagulation variables and possible deletions. Nine of the probands and their families were further investigated with DNA linkage analyses. Different patterns of heredity can be suggested in our families with vWD type III, on the basis of blood coagulation analyses. The findings suggest homozygosity in five families and the possibility of compound heterozygosity or a new mutation in the proband in three families. The linkage analyses confirm the results of the coagulation analyses. The segregation of the von Willebrand factor (vWF) gene can be followed in the families, and carrier diagnosis can be made in several of the probands' relatives. The possibility of large deletions in the vWF gene of the probands and their parents was investigated with probes representing the whole vWF cDNA. No deletions were found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217114
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  • 3
    Electronic Resource
    Electronic Resource
    An Efficient Method for the Isolation of Peramine, an Insect Feeding Deterrent Produced by the Fungus Acremonium Lolii (1989)
    s.l. : American Chemical Society
    Journal of natural products 52 (1989), S. 193-195 
    Details
    ISSN: 1520-6025
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/np50061a030
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  • 4
    Electronic Resource
    Electronic Resource
    Ueda, Reed: Avenues to Adulthood: The Origins of the High School and Social Mobility in an American Suburb : Cambridge, Cambridge University Press, 1987 (1989)
    Cambridge : Cambridge University Press
    Journal of American studies 23 (1989), S. 108-109 
    Details
    ISSN: 0021-8758
    Source: Cambridge Journals Digital Archives
    Topics: English, American Studies , History , Political Science , Sociology , Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1017/S0021875800019332
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  • 5
    Electronic Resource
    Electronic Resource
    A symbiosis expressed non-ribosomal peptide synthetase from a mutualistic fungal endophyte of perennial ryegrass confers protection to the symbiotum from insect herbivory (2005)
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 57 (2005), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: While much is known about the biosynthesis of secondary metabolites by filamentous fungi their biological role is often less clear. The assumption is these pathways have adaptive value to the organism but often the evidence to support this role is lacking. We provide the first genetic evidence that the fungal produced secondary metabolite, peramine, protects a host plant from insect herbivory. Peramine is a potent insect feeding deterrent synthesized by Epichloë/Neotyphodium mutualistic endophytes in association with their grass hosts. The structure of peramine, a pyrrolopyrazine, suggests that it is the product of a reaction catalysed by a two-module non-ribosomal peptide synthetase (NRPS). Candidate sequences for a peramine synthetase were amplified by reverse transcription polymerase chain reaction. Four unique NRPS products were identified, two of which were preferentially expressed in planta. One of these hybridized to known peramine producing strains. This clone was used to isolate an Epichloë festucae cosmid that contained a two-module NRPS, designated perA. Nine additional genes, which show striking conservation of microsynteny with Fusarium graminearum and other fungal genomes, were identified on the perA-containing cosmid. Associations between perennial ryegrass and an E. festucae mutant deleted for perA lack detectable levels of peramine. A wild-type copy of perA complemented the deletion mutant, confirming that perA is a NRPS required for peramine biosynthesis. In a choice bioassay, plant material containing the perA mutant was as susceptible to Argentine stem weevil (ASW) (Listronotus bonariensis) feeding damage as endophyte-free plants confirming that peramine is the E. festucae metabolite responsible for ASW feeding deterrent activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.2005.04747.x
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  • 6
    Electronic Resource
    Electronic Resource
    Preliminary sea breeze studies over Bathurst and Melville Islands, northern Australia, as part of the island thunderstorm experiment (ITEX) (1994)
    Springer
    Meteorology and atmospheric physics 53 (1994), S. 77-94 
    Details
    ISSN: 1436-5065
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Summary The “maritime continent” area to the north of Australia is one of three major global centres of tropical convective activity and has a fundamental role in the general circulation of the atmosphere. Tropical convection within this region is dominated by island thunderstorm activity which is strongly diurnally modulated, is deep and is geographically fixed. The storms over Bathurst and Melville Islands (11.5°S, 131°E) are representative of island thunderstorms that occur throughout the maritime continent and are believed to be primarily a response to sea breeze convergence. In this paper, we produce an indicative climatology of the Melville and Bathurst Island sea breeze (obtained during a three week period of the 1988 transition season), and we examine the surface patterns of island-scale convergence and divergence, especially in relation to the diurnal modulation of island thunderstorm activity. These observations are placed in the context of the broadscale environment and the relevant surface energy balance and radiation regimes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01031906
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  • 7
    Electronic Resource
    Electronic Resource
    Fungal endophyte-infected grasses: Alkaloid accumulation and aphid response (1990)
    Springer
    Journal of chemical ecology 16 (1990), S. 3301-3315 
    Details
    ISSN: 1573-1561
    Keywords: Endophyte-infected grasses ; Acremonium ; endophytes ; Epichloe typhina ; grass alkaloids ; lolines ; ergovaline ; peramine ; lolitrem B ; aphid responses ; plant resistance to herbivory ; Rhopalosiphum padi ; Schizaphis graminum ; Homoptera ; Aphididae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The occurrence of the alkaloidsN-formyl andN-acetyl loline, peramine, lolitrem B, and ergovaline and the response of aphids to plants containing these compounds were determined in species and cultivars ofFestuca,Lolium, and other grass genera infected with fungal endophytes (Acremonium spp., andEpichloe typhina). Twenty-nine of 34 host-fungus associations produced one or more of the alkaloids, most frequently peramine or ergovaline. Three alkaloids (lolines, peramine, and ergovaline) were found in tall fescue and in perennial ryegrass infected withA. coenophialum, while peramine, lolitrem B, and ergovaline were present in perennial ryegrass and in tall fescue infected withA. lolii and inF. longifolia infected withE. typhina. WhileA. coenophialum andA. lolii produced similar patterns of alkaloids regardless of the species or cultivar of grass they infected, isolates ofE. typhina produced either no alkaloids or only one or two different alkaloids in the grasses tested. Aphid bioassays indicated thatRhopalosiphum padi andSchizaphis graminum did not survive on grasses containing loline alkaloids and thatS. graminum did not survive on peramine-containing grasses. Ergovaline-containing grasses did not affect either aphid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00982100
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  • 8
    Electronic Resource
    Electronic Resource
    The application of science and scientific autonomy in Great Britain: A case study of the Science and Engineering Research Council (1993)
    Springer
    Minerva 31 (1993), S. 38-55 
    Details
    ISSN: 1573-1871
    Source: Springer Online Journal Archives 1860-2000
    Topics: Education , Nature of Science, Research, Systems of Higher Education, Museum Science
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01096171
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  • 9
    Electronic Resource
    Electronic Resource
    Coated ultrafine precipitated CaCO3 as impact modifier extender in low molecular weight PVC (1986)
    Brookfield, Conn. : Wiley-Blackwell
    Journal of Vinyl and Additive Technology 8 (1986), S. 120-125 
    Details
    ISSN: 0193-7197
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Work reported earlier had shown that the addition of 0.07 micron stearate coated ultrafine precipitated CaCO3 (CUPCC) in medium to high molecular weight PVC resulted in a significant improvement in notched Izod impact strength. The improvement was much more dramatic when the filler loading exceeded 10 phr. The addition of CUPCC to low molecular weight PVC had practically no effect on the notched Izod impact strength at equivalent loadings. More recent studies have demonstrated that when CUPCC is added to an impact modified low molecular weight PVC, it dramatically enhances the efficiency of impact modifier. This was found to be consistent with threee general classes of commercially available impact modifiers used in this study. The ability to extend the impact modifier with CUPCC in low molecular weight PVC, which has gained a wide acceptance in injection molding operations, will result in significant cost savings. The effect of CUPCC addition on other key properties and cost benefits will also be presented.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/vnl.730080308
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  • 10
    Electronic Resource
    Electronic Resource
    Guest editorial (1992)
    Brookfield, Conn. : Wiley-Blackwell
    Journal of Vinyl and Additive Technology 14 (1992), S. 125-125 
    Details
    ISSN: 0193-7197
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/vnl.730140302
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