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  • 1
    ISSN: 1432-0630
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 54 (1998), S. 479-481 
    ISSN: 1432-1041
    Keywords: Key words CYP2D6 ; CYP2C19 ; Elderly
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: Eighty-three healthy elderly Swedish subjects (age 87 ± 4 years, mean ± SD, range 80–98 years) were genotyped with respect to the two genetic polymorphisms of oxidative drug metabolism, CYP2D6 and CYP2C19, using allele-specific polymerase chain reaction (PCR). A control population consisted of 248 younger unrelated healthy volunteers (age 31 ± 9 years, range 19–63 years) for CYP2D6, and 162 (age 30 ± 8 years, range 19–55 years) for CYP2C19. Results: No significant differences were found between the control groups and the elderly subjects with respect to the frequencies of the defect alleles CYP2D6*3, CYP2D6*4, CYP2C19*2 and CYP2C19*3. Neither were there any differences in the genotype frequencies, or the predicted phenotype frequencies. The study indicates that the CYP2D6 and CYP2C19 genotypes play no major role in the probability of reaching high age. Conclusion: No genetically determined differences in the pharmacokinetics of drugs metabolized by these two polymorphic enzymes are to be expected in the oldest age groups compared with younger adults.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1041
    Keywords: Phenytoin ; Gingival hyperplasia ; p-HPPH enantiomers ; CYP2C ; fibroblast culture ; adverse effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The purpose of this study was to assess the possible role of the (R)- and (S)- enantiomers of the phenytoin metabolite p-HPPH in the pathogenesis of gingival hyperplasia (GH). About 98% of circulating p-HPPH is in the (S)-form. There were significant differences between patients with and without GH in (R)-p-HPPH level (0.055 vs 0.042 μg·ml−1), both enantiomer/racemate level ratios, and R/S enantiomeric ratio (0.0313 vs 0.0232); an increase in serum (R)-p-HPPH level was observed in patients with GH. In separate experiments, the effect of p-HPPH enantiomers on the proliferation of the normal human dermal fibroblast was studied. The in vitro study showed that (R)-p-HPPH selectively stimulated fibroblast growth. The results suggest that the least abundant metabolite, (R)-p-HPPH, is the most toxic with respect to gingival hyperplasia.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The Advanced Toroidal Facility (ATF) [Fusion Technol. 10, 179 (1986)] is the world's largest stellarator. It was designed and built to demonstrate high beta, steady-state operation in a toroidal confinement system. During its final operating period ATF achieved pulse lengths of over one hour (4667 s). The objectives of these experiments were (1) investigation of plasma performance at times that are long compared to the plasma/wall equilibrium time; (2) determination of plasma control and wall conditioning techniques; and (3) adaptation of plasma diagnostic and data acquisition systems to long-pulse operation. Other experiments have also extended earlier studies of dimensionless-parameter plasma confinement scaling. By employing two discrete electron cyclotron heating (ECH) frequencies (28 and 35 GHz), and by simultaneously modulating the ECH power, magnetic field, and plasma density, it has been possible to maintain fixed plasma beta and collisionality while modulating the normalized gyroradius. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The Large Helical Device (LHD) experiments [O. Motojima, et al., Proceedings, 16th Conference on Fusion Energy, Montreal, 1996 (International Atomic Energy Agency, Vienna, 1997), Vol. 3, p. 437] have started this year after a successful eight-year construction and test period of the fully superconducting facility. LHD investigates a variety of physics issues on large scale heliotron plasmas (R=3.9 m, a=0.6 m), which stimulates efforts to explore currentless and disruption-free steady plasmas under an optimized configuration. A magnetic field mapping has demonstrated the nested and healthy structure of magnetic surfaces, which indicates the successful completion of the physical design and the effectiveness of engineering quality control during the fabrication. Heating by 3 MW of neutral beam injection (NBI) has produced plasmas with a fusion triple product of 8×1018 keV m−3 s at a magnetic field of 1.5 T. An electron temperature of 1.5 keV and an ion temperature of 1.4 keV have been achieved. The maximum stored energy has reached 0.22 MJ, which corresponds to 〈β〉=0.7%, with neither unexpected confinement deterioration nor visible magnetohydrodynamics (MHD) instabilities. Energy confinement times, reaching 0.17 s at the maximum, have shown a trend similar to the present scaling law derived from the existing medium sized helical devices, but enhanced by 50%. The knowledge on transport, MHD, divertor, and long pulse operation, etc., are now rapidly increasing, which implies the successful progress of physics experiments on helical currentless-toroidal plasmas. © 1999 American Institute of Physics.
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  • 6
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 2281-2285 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We introduce a magnetic force controlled atomic force microscope (AFM) and point contact probe for use in ultrahigh vacuum and describe how our technique can significantly enhance the current capabilities of scanning probe microscopes. The instrument is specially designed to provide quantitative information on the nature of the tip-surface interaction. Forces are applied directly to magnetic material deposited behind the AFM tip via a current carrying coil. Oscillating the applied force and measuring the resulting displacement amplitude gives a continuous measurement of the absolute force gradient or contact stiffness. From this measurement the contact area or effective interaction area can be calculated for clean surfaces, thus eliminating the problems of unknown resolution and also facilitating the study of conduction and mechanical properties of small volumes. © 1996 American Institute of Physics.
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  • 7
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 86 (1999), S. 5993-5999 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Extended x-ray absorption fine structure (EXAFS), Rutherford-backscattering ion channeling, and particle induced x-ray emission channeling (PIXE/C) measurements have been performed in order to investigate compensation centers in Cl doped ZnSeTe. The EXAFS results from Cl doped ZnSeTe suggest that almost all Cl atoms are incorporated into substitutional Se lattice sites, which seems to indicate that Cl atoms themselves are not responsible for the compensation centers. The PIXE/C angular profiles were measured across the 〈100〉, 〈110〉, and 〈111〉 axes for undoped ZnSeTe. Comparing the angular profiles for Zn Kα, Se Kα, and Te Lα x-ray yields, it was found that some portion of the Te atoms (∼1020 cm−3) are located at tetrahedral interstitial sites. From these results, the difficulty of realizing n-type ZnSeTe is considered to be due to the existence of the interstitial Te atoms which act as acceptors. © 1999 American Institute of Physics.
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  • 8
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 68 (1996), S. 579-581 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A combined atomic force and scanning near-field optical microscope is presented. The critical component of the instrument is a single crystal silicon, microfabricated force-sensing cantilever with an integrated photodiode. Near-field optical images are obtained by monitoring variations in the optical power detected by the photodiode while the cantilever tip is scanned in an evanescent optical field created by illuminating the sample by total internal reflection. Near-field optical power was detected at tip-sample spacings of one-quarter wavelength. Atomic force and scanning near-field optical microscope images of the same samples show corresponding features as small as 25 nm. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 67 (1995), S. 872-874 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Micromachining Teflon was achieved by direct exposure to synchrotron radiation and the microstructures made had the smallest surface detail down to 20 μm with structural height of more than 200 μm, that is, aspect ratio on the order of 10. The quality of micromachining Teflon by this process was found to be critically dependent on photon flux of the synchrotron radiation. Analysis of the mass distribution of gaseous species formed upon this process suggested that photochemical processes rather than pyrolytic processes may still dominate. © 1995 American Institute of Physics.
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  • 10
    Electronic Resource
    Electronic Resource
    Chester : International Union of Crystallography (IUCr)
    Journal of synchrotron radiation 5 (1998), S. 1326-1331 
    ISSN: 1600-5775
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: The status of the world's smallest electron storage ring is reported. This ring is designed to provide coherent far-infrared (FIR) and incoherent hard X-ray emissions from a single 50 MeV storage ring. The FIR emission is forced by a surrounding mirror around the electron orbit. The FIR emission mechanism is rather similar to that of the free-electron laser. The expected FIR output is of the order of 100 W. Bremsstrahlung is used instead of synchrotron radiation to generate hard X-rays. Since electrons recirculate and gain energy from the accelerating cavity, the expected hard X-ray brightness exceeds that of a rotating-anode source by about 1000 times or more.
    Type of Medium: Electronic Resource
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