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  • 1
    Electronic Resource
    Electronic Resource
    Some Aspects of Precipitation Hardening in Aluminum Alloy 6056 T6 - T.E.M. Experiments - (1996)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 217-222 (May 1996), p. 1305-1310 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/02/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.217-222.1305.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Local Spin Waves in Heisenberg Ferromagnets with Dipolar Field Coupling (1999)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 302-303 (Jan. 1999), p. 380-383 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/04/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.302-303.380.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    The leader peptide is essential for the post-translational modification of the DNA-gyrase inhibitor microcin B17 (1997)
    Oxford BSL : Blackwell Science Ltd
    Molecular microbiology 23 (1997), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Microcin B17 (MccB17) is a ribosomally encoded DNA-gyrase inhibitor. Ribosomally encoded antibiotics are derived from precursors containing an N-terminal leader, which is removed during maturation, and a C-terminal structural peptide. PreMccB17, the translational product of mcbA, is modified into proMccB17 by the action of three enzymes, McbB, McbC, and McbD. A chromosomally encoded peptidase then converts proMccB17 into MccB17. The role of McbB, McbC, and McbD is to convert glycine, cysteine, and serine residues present in preMccB17 into four thiazole and four oxazole rings. Using a modification-specific antibody rather than antimicrobial activity, we show that the 26-amino-acid N-terminal leader of preMccB17 is essential for the conversion of preMccB17 into proMccB17. Neither a preMccB17 peptide lacking the leader nor a preMccB17–β-galactosidase fusion lacking the leader are post-translationally modified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2958.1997.2041565.x
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  • 4
    Electronic Resource
    Electronic Resource
    Stripping of ion beams by multiple passes through a plasma medium : Proceedings of the 7th international conference on ion sources (1998)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 671-673 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A method to increase the charge state of multicharged ions is explored. The method is based on stripping, during multiple passes, of an initially low charge-state ion beam through a plasma medium with energetic electrons heated at the electron cyclotron resonance. The key feature of the system is a magnetic recirculating line which has a built-in stripping chamber and a system of entrance-exit apertures. The recirculating line comprises a magnetic low-loss ion guide which delivers ions being passed through the stripping chamber to its entrance. As a stripping medium, a hydrogen plasma confined in a magnetic trap of cusp configuration is proposed. To model the conversion of initially injected ions with charge state ζ=1 to higher states, basic parameters of the stripping chamber can be estimated as follows: microwave frequency: 14.4 GHz; effective plasma length 10–30 cm; gas pressure: 1×10−5 Torr. Results of numerical calculation of the proposed stripping process show that an increase of ion charge is possible with acceptable deterioration of ion beam characteristics. Conversion efficiency, for example, for 103Pd from ζ=1 to ζ=5 for these parameters is about 80%. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1148666
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  • 5
    Electronic Resource
    Electronic Resource
    Hydrogen negative ion production in an electron cyclotron resonance driven plasma : Proceedings of the 7th international conference on ion sources (1998)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 950-952 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A 2.45 GHz microwave hydrogen discharge in a magnetic mirror trap created by disk poles is studied with respect to negative ion production. The distance between the permanent magnets was set so that the magnetic equipotentials corresponding to electron cyclotron resonance condition and the first three harmonics form concentric rings at the middle plain of the trap. The radii of azimuthally rotating rings could be varied by changing the distance between poles. It is found that the negative ion generation efficiency depends sharply on microwave power, gas pressure, and the distance between the plasma electrode of the extraction system and the nearest ring. The maximum current density of 67 mA/cm2 is observed at microwave power of 200 W and pressure of 0.2 mTorr when a ring corresponding to the second harmonic is in contact with the surface of the plasma extraction electrode. The enhancement of the negative hydrogen ion production when the plasma electrode touches the resonance heating rings is explained by a two step process: vibrational excitation of molecules in the discharge volume and the dissociation of these molecules in a layer of low energy electrons. Vibrational excited hydrogen molecules are formed in the discharge volume by plasma electrons. This process is followed by a dissociative attachment of low energetic, secondary electrons from the plasma electrode, which are created by the ring ion and electron bombardment of the surface. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1148618
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  • 6
    Electronic Resource
    Electronic Resource
    On the Protection by Inorganic Phosphate of Calcium-Induced Membrane Permeability Transition (1997)
    Springer
    Journal of bioenergetics and biomembranes 29 (1997), S. 571-577 
    Details
    ISSN: 1573-6881
    Keywords: Mitochondrial calcium ; inorganic phosphate ; membrane permeability transition ; calcium transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract The role of inorganic phosphate as inhibitor of mitochondrial membrane permeability transition was studied. It is shown that in mitochondria containing a high phosphate concentration, i.e., 68 nmol/mg, Ca2+ did not activate the pore opening. Conversely, at lower levels of matrix phosphate, i.e., 38 nmol/mg, Ca2+ was able to induce subsequent pore opening. The inhibitory effect of phosphate was apparent in sucrose-based media, but it was not achieved in KCl media. The matrix free Ca2+ concentration and matrix pH were lowered by phosphate, but they were always higher in K+-media. In the absence of ADP, phosphate strengthened the inhibitory effect of cyclosporin A on carboxyatractyloside-induced Ca2+ efflux. Acetate was unable to replace phosphate in the induction of the aforementioned effects. It is concluded that phosphate preserves selective membrane permeability by diminishing the matrix free Ca2+ concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022483018482
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  • 7
    Electronic Resource
    Electronic Resource
    Systematic status and first description of male of Dujardinia cenotae Pearse, 1936 [= Hysterothylacium cenotae (Pearse, 1936) Moravec et al., 1995] (Nematoda: Anisakidae) (1996)
    Springer
    Systematic parasitology 33 (1996), S. 143-148 
    Details
    ISSN: 1573-5192
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A new collection of adult anisakid nematodes from the intestine of the catfish Rhamdia guatemalensis from two cenotes (= sinkholes) and a cave in the Yucatan Peninsula, southeastern Mexico, has shown that they are conspecific with those inadequately described as Dujardinia cenotae Pearse, 1936. The female is redescribed and the male is described for the first time. The morphology of this species shows that it belongs to the genus Hysterothylacium. This is the only Hysterothylacium species recorded from freshwater fishes in Mexico and it may well be endemic to cenotes and caves of the Yucatan Peninsula.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00009431
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  • 8
    Electronic Resource
    Electronic Resource
    Pathogenicity of Hansenula anomala in a model of immunocompromised mice (1998)
    Springer
    Mycopathologia 144 (1998), S. 67-71 
    Details
    ISSN: 1573-0832
    Keywords: Candida albicans ; experimental pathogenicity ; Hansenula anomala ; immunocompromised mice ; mycoses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Systemic infections caused by opportunistic fungi have shown an increased frequency in the past 10 years, particularly in immunocompromised patients. Hansenula anomala is an ascosporogenous yeast of the Ascomycetes class found in the skin, throat, and digestive tract transient normal flora. This study was conducted to compare the pathogenicity of H. anomala and Candida albicans in a model of immunocompromised mice. Thirty-eight Swiss mice were divided into two groups as follows: 30 animals received an intraperitoneal (i.p.) injection of cyclophosphamide (200 mg/kg) four days before the induction of infection with H. anomala (1 × 106 yeasts/mL), and 8 animals received 100 mg/kg of cyclophosphamide at 3-day intervals during 3 weeks before inoculation of 1 × 107 yeasts/mL. All animals were treated with amoxicillin/clavulanic acid (40 mg/kg) four days before induction of infection. A group of mice inoculatd with C. albicans (ATCC 64548) served as control. Tissue samples from the lung, spleen, liver, and kidney for histological and mycologic studies were obtained at necropsy. In each animal, the number of viable yeasts per gram of kidney was determined. The organs most frequently infected by H. anomala were the kidneys and the liver (20%), and the lung (10%). However, in conditions of sustained immunosuppression, H. anomala was found in 65.5% of the organs examined. It is concluded that in an experimental model of immunocompromised mice, the pathogenicity of H. anomala was low.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007034905295
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  • 9
    Electronic Resource
    Electronic Resource
    Inhibition of human topoisomerase II by anti-neoplastic benzazolo[3,2-a]quinolinium chlorides (1998)
    Springer
    Molecular and cellular biochemistry 178 (1998), S. 203-212 
    Details
    ISSN: 1573-4919
    Keywords: antitumor ; DNA intercalator ; cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Previously we reported [20] that there is no correlation between the cytotoxic activity of four new structural analogs of the antitumor DNA intercalator 3-nitrobenzothiazolo[3,2-a]quinolinium chloride (NBQ-2) and their interaction with DNA. In the present study, we present evidence suggesting that the molecular basis for the anti-proliferative activity of these drugs is the inhibition of topoisomerase II. The NBQ-2 derivatives inhibited the relaxation of supercoiled DNA plasmid pRYG mediated by purified human topoisomerase II. Inhibition of the decatenation of kinetoplast DNA mediated by partially purified topoisomerase II extracted from the human histiocytic lymphoma U937 (a cell line previously shown to be sensitive to the drugs) was also caused by these drugs. The potency of the benzazolo[3,2-a]quinolinium drugs against topoisomerase II in vitro was the following: 7-(1-propenyl)-3-nitrobenzimidazolo[3,2-a]quinolinium chloride (NBQ-59) 〉 4-chlorobenzothiazolo[3,2-a]quinolinium chloride (NBQ-76) 〉 7-ethyl-3-nitrobenzimidazolo[3,2-a]quinolinium chloride (NBQ-48) 〉 7-benzyl-3-nitrobenzimidazolol[3,2-a]quinolinium chloride (NBQ-38). This rank of potency for topoisomerase II inhibition correlated very well with the cytotoxicity elicited by these drugs. Furthermore, significant levels of topoisomerase II/DNA cleavage complex induced by these drugs in vivo were detected when U937 cells were treated with NBQ-59 and NBQ-76 whereas NBQ-38 and NBQ-38 and NBQ-48 produced negligible amounts of the cleavage complex. Our results strongly suggest that topoisomerase II is the major cellular target of this family of compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006847615575
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  • 10
    Electronic Resource
    Electronic Resource
    Dna binding-independent anti-proliferative action of benzazolo[3,2-α]quinolinium DNA intercalators (1997)
    Springer
    Molecular and cellular biochemistry 177 (1997), S. 69-77 
    Details
    ISSN: 1573-4919
    Keywords: molecular mechanism of drug action ; DNA-drug interaction ; anti-neoplastic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The proposed mechanism of action of the antineoplastic drug 3-nitrobenzothiazolo[3,2-& agr;]quinolinium chloride (NBQ-2) involves its interaction with DNA by intercalation and inhibition of topoisomerase II activity by arresting the enzyme in a covalent cleavage complex. In an attempt to identify some structural determinants for activity and develop a molecular structure/cytotoxicity correlation, four new structural analogs of the antitumor NBQ-2 were prepared and their cytotoxic activity and DNA binding properties were investigated. The cytotoxic activity was evaluated against six different human tumor cell lines: U937, K-562, HL-60, HT-29, HeLa, and A431. The results showed that these new drugs elicit pronounced cytotoxic effects against U937, K-562, HL-60 and A431 while HeLa and HT-29 were less sensitive to the new drugs. This apparent selectivity was different to that of m-AMSA, a drug currently used for cancer treatment. Since the interaction of NBQ-2 to DNA by intercalation has been proposed as the initial step leading to its antineoplastic activity, DNA binding and changes in DNA contour length induced by the new NBQ-2 structural analogs were also investigated using calf thymus and human DNA. The drug, 7-(1-propenyl)-3-nitrobenzimidazolo[3,2-& agr;]quinolinium chloride (NBQ-59) was the most cytotoxic agent of the analog series (IC50 = 16 & mgr;M for HL-60 cells), however, it demonstrated the weakest binding to DNA (Kint = 0.9 × 105 M-1 for calf thymus DNA). NBQ-59 was also found to be a poor intercalator into the DNA double helix. Therefore, our results suggest that DNA binding is not the primary mechanism of drug action for this family of compounds. In addition structural determinants important for cytotoxicity of the benzazolo quinolinium chlorides were suggested by our results. In particular, the nitro group in the 3 position does not seem to be necessary for bioactivity, while substitutions in the benzazolo moiety have striking effects on the biological activity of the drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006857118469
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