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  • 1
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    Processing of Artificial Peptide-DNA-Conjugates by the Mitochondrial Intermediate Peptidase (MIP) (1999)
    De Gruyter
    Details
    Publication Date: 1999-01-01
    Print ISSN: 1431-6730
    Electronic ISSN: 1437-4315
    Topics: Biology , Chemistry and Pharmacology
    Published by De Gruyter
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    PAPER CURRENT
  • 2
    Electronic Resource
    Electronic Resource
    Biochemical Markers of Bone Turnover Reflect Femoral Bone Loss in Elderly Women (1996)
    Springer
    Calcified tissue international 59 (1996), S. 328-333 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Osteoporosis — Elderly women — Biochemical markers — Bone loss — DXA.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Although over 90% of hip fractures occur in patients over age 70, few data are available on femoral bone loss in this age group. To examine the relationship between biochemical markers of bone turnover and femoral bone loss in the elderly, 36 female and 17 male, healthy, community-dwelling elderly over age 65 (mean ± SD age: women 71 ± 4 years, men 75 ± 5 years) were followed for 3 years. Annual bone mineral density measurements of the hip and lumbar spine by dual-energy x-ray absorptiometry (DXA) were obtained and biochemical markers of bone resorption (urinary N-telopeptide crosslinks, free pyridinoline, total pyridinoline, total deoxypyridinoline, and hydroxyproline) and bone formation (serum osteocalcin, bone-specific alkaline phosphatase) were obtained at the end of year 3. In elderly women, longitudinal bone loss at the total hip was negatively correlated with markers of bone resorption (r =−0.39 to −0.52, P 〈 0.05), bone formation (r =−0.38, P 〈 0.05), and age (r =−0.39, P 〈 0.05). Markers of bone resorption were correlated with markers of bone formation (r = 0.63 to 0.74, P 〈 0.01). In multiple regression analysis, urinary N-telopeptide crosslinks (marker of resorption), serum osteocalcin (marker of formation), and serum parathyroid hormone explained 43% of the variability of bone loss at the total hip in women. These parameters were not related to bone loss in men. We conclude that femoral bone loss increases with age in women over 65. Measurements of specific biochemical markers of bone turnover are correlated with longitudinal bone loss in elderly women. These markers may help identify women at greatest risk for bone loss who would benefit most from therapeutic interventions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900135
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  • 3
    Electronic Resource
    Electronic Resource
    Deep-breathing cephalopods? (1996)
    [s.l.] : Nature Publishing Group
    Nature 384 (1996), S. 421-421 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR — Madan and Wells1 have explored the relationship between gill area and habitat depth. They suggest that the large gill areas found in some pelagic cephalopods enable them to cope with the hypoxic conditions present throughout much of the deep sea. This conclusion is not surprising as ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/384421b0
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  • 4
    Electronic Resource
    Electronic Resource
    Vampire blood: respiratory physiology of the vampire squid (Cephalopoda: Vampyromorpha) in relation to the oxygen minimum layer (1999)
    Springer
    Experimental biology online 4 (1999), S. 1-10 
    Details
    ISSN: 1430-3418
    Keywords: Deep sea ; Haemocyanin ; Hypoxia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The functional properties of the haemocyanin ofVampyroteuthis infernalis (Cephalopoda: Vampyromorpha), measured at 5 °C, are reported and discussed in relation to hypoxia. The oxygen affinity of this haemocyanin (P50=0.47−0.55 kPa) is higher than any previously measured for a cephalopod. The high cooperativity (n50=2.20−2.23) and Bohr coefficient (−0.22) suggest a true transport function for this haemocyanin. This high-affinity haemocyanin, in conjunction with moderate gill diffusion capacity, provides a sufficient oxygen gradient from the environment to the blood to support the low routine oxygen consumption rate of V. infernalis
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00898-999-0001-2
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  • 5
    Electronic Resource
    Electronic Resource
    Öko-Audit im Dienstleistungssektor (1999)
    Springer
    Standort 23 (1999), S. 42-45 
    Details
    ISSN: 1432-220X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography
    Notes: Einleitung Seit die “Verordnung... über die freiwillige Beteiligung gewerblicher Unternehmen an einem Gemeinschaftssystem für das Umweltmanagement und die Umweltbetriebsprüfung” (Öko-Audit) im Jahr 1993 verabschiedet worden ist, hat die Zahl der Unternehmen, die sich an dem freiwilligen System beteiligen, stetig zugenommen. In Deutschland wird das System im Vergleich zu den anderen Mitgliedsstaaten der EU weitaus besser angenommen, so daß Deutschland zahlenmäßig die meisten auditierten Unternehmen aufweisen kann: Vom Frühjahr 1996 bis Januar 1997 stieg die Zahl der auditierten Unternehmen von ca. 200 auf über 500 (vgl. Vollmer, Braun & Soyez 1996, S. 534). Bislang beschränkt sich das Öko-Audit noch auf Unternehmen des produzierenden Gewerbes, während Dienstleistungsbetriebe Umweltmanagementsysteme “in Anlehnung” an das Ouml;ko-Audit einrichten oder auf die ISO 14000 ausweichen. Ebenso wie das Ouml;ko-Audit ist auch die ISO 14000 eine Norm, die die Einrichtung eines Umweltmanagementsystems nach bestimmten Maßgaben regelt. Anders als das Ouml;ko-Audit steht die ISO 14000 bereits allen Branchen offen und ist zudem weltweit bekannter (Dyllik & Hummel 1995, S. 25 f.). Die Konkurrenz zwischen beiden Systemen und der starke Anstieg der Zahl der auditierten Unternehmen waren der Anlaß, sich genauer mit den Innovationen “Ouml;ko-Audit” bzw. “Umweltmanagementsystem” auseinanderzusetzen. Insbesonders die schnell wachsende Zahl der auditierten Unternehmen und das Interesse der Dienstleistungsbetriebe auch am Gemeinschaftssystem “Ouml;ko-Audit” teilzunehmen, waren der Grund für die Annahme, daß sich das Ouml;ko-Audit nicht von selbst derart schnell ausbreitet, sondern daß die Ausbreitung unterstützt – also gesponsert – wird. Banken könnten nach Annahme der Autoren in diesem Prozeß in zweierlei Hinsicht eine interessante Rolle haben: Auf der einen Seite haftet den Banken ebenso wie allen anderen Dienstleistungsunternehmen das Image des “sauberen Dienstleisters” an, dessen Produktion keine Umweltauswirkungen zu haben scheint. Was für einen Sinn sollte also das Umweltengagement von Dienstleistungsunternehmen oder gar die Einrichtung eines Umweltmanagementsystems vor diesem Hintergrund haben? Andererseits wird den Banken “in der Wirtschaft” eine Schlüsselrolle und Multiplikatorfunktion in jeder Hinsicht zugeschrieben (Burzler & Rauberger 1996 S. 1). Insbesonders diese Möglichkeiten der Banken, den Ausbreitungsprozeß der Innovation “Ouml;ko-Audit” zu steuern und zu beschleunigen, waren Gegenstand der vorliegenden Untersuchung. Dazu wurden leitfadengestützte Interviews mit Vertretern verschiedener Abteilungen von deutschen Banken durchgeführt (im folgenden Text anonymisiert).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005489970018
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  • 6
    Electronic Resource
    Electronic Resource
    Synthesis and Preclinical Pharmacology of 2-(2-Aminopyrimidinio) Ethylidene-1,1-Bisphosphonic Acid Betaine (ISA-13-1)-A Novel Bisphosphonate (1999)
    Springer
    Pharmaceutical research 16 (1999), S. 1399-1406 
    Details
    ISSN: 1573-904X
    Keywords: bisphosphonates (diphosphonates) ; calcium-related disorders ; bone-related disorders ; drug administration ; drug absorption tight junctions ; mannitol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. To validate our hypothesis that a bisphosphonate (BP) having a nitrogen-containing heterocyclic ring on the side chain, and with no hydroxyl on the geminal carbon would possess increased activity, and better oral bioavailability due to enhanced solubility of its calcium complexes/salts and weaker Ca chelating properties. Methods. A novel BP, 2-(2-aminopyrimidinio)ethylidene-l,l-bisphosphonic acid betaine (ISA-13-1) was synthesized. The physicochemical properties and permeability were studied in vitro. The effects on macrophages, bone resorption (young growing rat model), and tumor-induced osteolysis (Walker carcinosarcoma) were studied in comparison to clinically used BPs. Results. The solubility of the Ca salt of ISA-13-1 was higher, and the log βCa: BP stability constant and the affinity to hydroxyapatite were lower than those of alendronate and pamidronate. ISA-13-1 exhibited effects similar to those of alendronate on bone volume, on bone osteolysis, and on macrophages, following delivery by liposomes. ISA-13-1 was shown to have 1.5−1.7 times better oral absorption than the other BPs with no deleterious effects on the tight junctions of intestinal tissue. Conclusions. The similar potency to clinically used BPs, the increased oral absorption as well as the lack of effect on tissue tight junction of ISA-13-1 warrant its further consideration as a potential drug for bone diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018951025493
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  • 7
    Electronic Resource
    Electronic Resource
    Mitochondrial DNA mutations in multiple symmetric lipomatosis (1997)
    Springer
    Molecular and cellular biochemistry 174 (1997), S. 271-275 
    Details
    ISSN: 1573-4919
    Keywords: multiple symmetric lipomatosis ; mitochondrial DNA ; MERRF
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Multiple symmetric lipomatosis (MSL) is a rare disorder of middle life characterized by large subcutaneous fat masses around the neck, shoulders and other parts of the trunk. Peripheral neuropathy is a common finding in these predominantly male patients. Employing electrophysiological measures, we found additional signs of central nervous system involvement in a majority of patients. Etiologically, there is an association with mitochondrial dysfunction. In muscle biopsy, we found ragged red fibers in 8 of 12 patients. Molecular genetic analysis revealed multiple deletions of mitochondrial DNA in one patient and the MERRF mutation at nucleotide 8344 in another. In this review, we summarize our clinical, electrophysiological morphological, biochemical and molecular genetic findings in 17 MSL patients, and give a survey of the literature. (Mol Cell Biochem 174: 271–275, 1997)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006877012241
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  • 8
    Electronic Resource
    Electronic Resource
    New microtubular agents in pediatric oncology (1996)
    Springer
    Investigational new drugs 14 (1996), S. 49-54 
    Details
    ISSN: 1573-0646
    Keywords: docetaxel ; microtubules ; paclitaxel ; taxanes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The taxanes are a new group of anticancer agents with a novel mechanism of action. They promote microtubule assembly and stabilize the microtubules. Paclitaxel (Taxol), the first agent in this group in clinical trials was isolated from the Pacific yew, Taxus brevifolia in 1971. Both in preclinical and clinical studies, paclitaxel and its semisynthetic analog docetaxel exhibit significant antitumor activity. This review will provide an overview of the clinical experience with the group of anti-microtubular agents, the taxanes in pediatric oncology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00173682
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  • 9
    Electronic Resource
    Electronic Resource
    Optimization and experimental investigations of stiffened, axially compressed CFRP-panels (1998)
    Springer
    Structural and multidisciplinary optimization 15 (1998), S. 124-131 
    Details
    ISSN: 1615-1488
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Thin-walled, unstiffened and stiffened shell structures made of fibre composite materials are frequently applied due to their high stiffness/strength to weight ratios in all fields of lightweight constructions. One major design criterion of these structures is their sensitivity with respect to buckling failure when subjected to inplane compression and shear loads. This paper describes how the structural analysis program BEOS (Buckling of Eccentrically Orthotropic Sandwich shells) is combined with the optimization procedure SAPOP (Structural Analysis Program and Optimization Procedure) to produce a tool for designing optimum CFRP-panels against buckling. Experimental investigations are used to justify the described procedures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01278498
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  • 10
    Electronic Resource
    Electronic Resource
    Interactions in Molecular Crystals, 123.Part 122, see Ref. Crystallization and Structure of Donor-Acceptor Complexes between Rigid or Conformationally Flexible Thio-Crowns and Iodine (1997)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1997 (1997), S. 2151-2159 
    Details
    ISSN: 0947-3440
    Keywords: Thiocrown donors ; Iodine complexes ; Structure elucidation ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Studies of π and σ interactions in molecular crystals of donoracceptor complexes have stimulated interest in the crystallization and structure determination of {1,3,5-trithiane…I2}, {1,5,8,12-tetrathiocyclotetradecane…I2} and {1,4,7,10,13,16-hexathiocyclooctadecane…(I2)3} in order to detect structural changes. The I—I bond lengths are stretched by up to 0.16 Å relative to the gas-phase value and prove iodine to be the acceptor species. Additional distance data 〉S…I2 and I—I from the Cambridge Structural Database establish a nonlinear correlation. In contrast, bond lengths and bond angles of the sulphide donors remain largely unperturbed on complexation, even when considerable conformational changes are observed. For example, on addition of four iodine molecules, the rather flexible 18-thio-crown-6 with a C2-symmetric bowl-shape is flattened to a Cs-symmetric rectangle. The structural results complement those reported for stronger acceptor effects of metal cations.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.199719971018
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