Publication Date:
1998-07-17
Description:
The leukocyte-specific adapter molecule SLP-76 (Src homology 2 domain-containing leukocyte protein of 76 kilodaltons) is rapidly phosphorylated on tyrosine residues after receptor ligation in several hematopoietically derived cell types. Mice made deficient for SLP-76 expression contained no peripheral T cells as a result of an early block in thymopoiesis. Macrophage and natural killer cell compartments were intact in SLP-76-deficient mice, despite SLP-76 expression in these lineages in wild-type mice. Thus, the SLP-76 adapter protein is required for normal thymocyte development and plays a crucial role in translating signals mediated by pre-T cell receptors into distal biochemical events.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clements, J L -- Yang, B -- Ross-Barta, S E -- Eliason, S L -- Hrstka, R F -- Williamson, R A -- Koretzky, G A -- GM53256/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1998 Jul 17;281(5375):416-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9665885" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptor Proteins, Signal Transducing
;
Animals
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B-Lymphocytes/cytology/immunology
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Gene Targeting
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Immunoglobulin M/blood
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Killer Cells, Natural/cytology
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*Leukopoiesis
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Lymph Nodes/cytology
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Lymphocyte Activation
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Lymphocyte Count
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Macrophages/cytology
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Mice
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Mice, Inbred C57BL
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Phosphoproteins/genetics/*physiology
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Protein-Tyrosine Kinases/metabolism
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Receptors, Antigen, T-Cell/metabolism
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Signal Transduction
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Spleen/cytology
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T-Lymphocytes/*cytology
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Thymus Gland/cytology
;
ZAP-70 Protein-Tyrosine Kinase
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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