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  • 1995-1999  (170)
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  • 1
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    Effect of joint sets on the strength and deformation of rock mass models (1998)
    In:  International Journal of Rock Mechanics and Mining Sciences, Kunming, China, Icelandic Meteorological Office, Ministry for the Environment, University of Iceland, vol. 35, no. 1, pp. 75-84, pp. 1059, (ISSN: 1340-4202)
    Details
    Publication Date: 1998
    Keywords: cracks and fractures (.NE. fracturing) ; Strength ; Crustal deformation (cf. Earthquake precursor: deformation or strain) ; Rock mechanics ; Physical properties of rocks ; Modelling
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    BIBLIOGRAPHY SEISMOLOGY
  • 2
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    The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-10-09
    Description: Ubiquitination of receptor protein-tyrosine kinases (RPTKs) terminates signaling by marking active receptors for degradation. c-Cbl, an adapter protein for RPTKs, positively regulates RPTK ubiquitination in a manner dependent on its variant SRC homology 2 (SH2) and RING finger domains. Ubiquitin-protein ligases (or E3s) are the components of ubiquitination pathways that recognize target substrates and promote their ligation to ubiquitin. The c-Cbl protein acted as an E3 that can recognize tyrosine-phosphorylated substrates, such as the activated platelet-derived growth factor receptor, through its SH2 domain and that recruits and allosterically activates an E2 ubiquitin-conjugating enzyme through its RING domain. These results reveal an SH2-containing protein that functions as a ubiquitin-protein ligase and thus provide a distinct mechanism for substrate targeting in the ubiquitin system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Joazeiro, C A -- Wing, S S -- Huang, H -- Leverson, J D -- Hunter, T -- Liu, Y C -- CA39780/CA/NCI NIH HHS/ -- R01 DK56558/DK/NIDDK NIH HHS/ -- T32CA09523/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1999 Oct 8;286(5438):309-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Salk Institute, Molecular Biology and Virology Laboratory, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10514377" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Cell Line ; Humans ; Ligases/chemistry/*metabolism ; Molecular Sequence Data ; Phosphotyrosine/metabolism ; Point Mutation ; Proto-Oncogene Proteins/chemistry/genetics/*metabolism ; Proto-Oncogene Proteins c-cbl ; Receptor Protein-Tyrosine Kinases/*metabolism ; Receptor, Platelet-Derived Growth Factor beta/metabolism ; Recombinant Fusion Proteins/metabolism ; Sequence Alignment ; Signal Transduction ; *Ubiquitin-Conjugating Enzymes ; Ubiquitin-Protein Ligases ; Ubiquitins/*metabolism ; src Homology Domains
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 3
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    Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-11-30
    Description: A combinatorial disulfide cross-linking strategy was used to prepare a stalled complex of human immunodeficiency virus-type 1 (HIV-1) reverse transcriptase with a DNA template:primer and a deoxynucleoside triphosphate (dNTP), and the crystal structure of the complex was determined at a resolution of 3.2 angstroms. The presence of a dideoxynucleotide at the 3'-primer terminus allows capture of a state in which the substrates are poised for attack on the dNTP. Conformational changes that accompany formation of the catalytic complex produce distinct clusters of the residues that are altered in viruses resistant to nucleoside analog drugs. The positioning of these residues in the neighborhood of the dNTP helps to resolve some long-standing puzzles about the molecular basis of resistance. The resistance mutations are likely to influence binding or reactivity of the inhibitors, relative to normal dNTPs, and the clustering of the mutations correlates with the chemical structure of the drug.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, H -- Chopra, R -- Verdine, G L -- Harrison, S C -- GM-18621/GM/NIGMS NIH HHS/ -- GM-39589/GM/NIGMS NIH HHS/ -- GM-44853/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1998 Nov 27;282(5394):1669-75.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9831551" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-HIV Agents/metabolism/*pharmacology ; Binding Sites ; Catalytic Domain ; Crystallization ; Crystallography, X-Ray ; DNA Primers/chemistry/metabolism ; DNA, Viral/chemistry/metabolism ; Deoxyribonucleotides/chemistry/metabolism ; Dimerization ; Drug Resistance, Microbial ; HIV Reverse Transcriptase/*chemistry/genetics/metabolism ; HIV-1/*drug effects/enzymology ; Humans ; Hydrogen Bonding ; Models, Molecular ; Mutation ; Nucleic Acid Conformation ; Protein Conformation ; Reverse Transcriptase Inhibitors/metabolism/*pharmacology ; Templates, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 4
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    Solution structure of a cisplatin-induced DNA interstrand cross-link (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-12-15
    Description: The widely used antitumor drug cis-diamminedichloroplatinum(II) (cisplatin or cis-DDP) reacts with DNA, cross-linking two purine residues through the N7 atoms, which reside in the major groove in B-form DNA. The solution structure of the short duplex [d(CAT-AGCTATG)]2 cross-linked at the GC:GC site was determined by nuclear magnetic resonance (NMR). The deoxyguanosine-bridging cis-diammineplatinum(II) lies in the minor groove, and the complementary deoxycytidines are extrahelical. The double helix is locally reversed to a left-handed form, and the helix is unwound and bent toward the minor groove. These findings were independently confirmed by results from a phase-sensitive gel electrophoresis bending assay. The NMR structure differs markedly from previously proposed models but accounts for the chemical reactivity, the unwinding, and the bending of cis-DDP interstrand cross-linked DNA and may be important in the formation and repair of these cross-links in chromatin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, H -- Zhu, L -- Reid, B R -- Drobny, G P -- Hopkins, P B -- GM32681/GM/NIGMS NIH HHS/ -- GM45804/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1995 Dec 15;270(5243):1842-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of Washington, Seattle 98195, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8525382" target="_blank"〉PubMed〈/a〉
    Keywords: Antineoplastic Agents/*pharmacology ; Base Sequence ; Cisplatin/*pharmacology ; DNA/*chemistry/drug effects ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Molecular Sequence Data ; *Nucleic Acid Conformation ; Solutions
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 5
    Electronic Resource
    Electronic Resource
    An Evaluation on H/V Ratio vs. Spectral Ratio for Site-response Estimation Using the 1994 Northridge Earthquake Sequences (1999)
    Springer
    Pure and applied geophysics 156 (1999), S. 631-649 
    Details
    ISSN: 1420-9136
    Keywords: Key Words: H/V ratio, spectral ratio, site response, microtremor, resonant frequency, amplification.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract —The applicability of the single-station H/V method, based on the spectral ratio between the horizontal and the vertical components of strong ground motions, is examined for site-response estimation using the high quality data from the 1994 Northridge earthquake sequence. Instead of using Rayleigh-wave data from microtremors, the large amplitude-wave part of the S-wave data is used and based on the 1994 Northridge mainshock and aftershock recordings. We have found that upon averaging over a number of recordings for a given station, the station site responses, derived both from the single-station H/V ratio and from the standard spectral ratio (with respect to a reference rock-site station) are sufficiently close for practical purposes. We therefore conclude that the H/V ratio can reasonably predict the resonant frequency and the amplification level of a site response, especially for sites in the neighborhood of the epicenters. In the absence of a reference rock-site station, the H/V ratio provides a practical alternative to the standard site-response estimation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000240050316
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  • 6
    Electronic Resource
    Electronic Resource
    Evidence for coupling between Na+ pump activity and TEA-sensitive K+ currents in Xenopus laevis oocytes (1995)
    Springer
    The journal of membrane biology 143 (1995), S. 29-35 
    Details
    ISSN: 1432-1424
    Keywords: Na+-K+-ATPase ; Electrophysiology ; K+ channel ; Tetraethylammonium ; Conductance regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Using the two-microelectrode voltage clamp technique in Xenopus laevis oocytes, we estimated Na+-K+-ATPase activity from the dihydroouabain-sensitive current (I DHO) in the presence of increasing concentrations of tetraethylammonium (TEA+; 0, 5, 10, 20, 40 mm), a well-known blocker of K+ channels. The effects of TEA+ on the total oocyte currents could be separated into two distinct parts: generation of a nonsaturating inward current increasing with negative membrane potentials (V M) and a saturable inhibitory component affecting an outward current easily detectable at positive V M. The nonsaturating component appears to be a barium-sensitive electrodiffusion of TEA+ which can be described by the Goldman-Hodgkin-Katz equation, while the saturating component is consistent with the expected blocking effect of TEA+ on K+ channels. Interestingly, this latter component disappears when the Na+-K+-ATPase is inhibited by 10 μm DHO. Conversely, TEA+ inhibits a component of I DHO with a k d of 25±4 mm at +50 mV. As the TEA+-sensitive current present in I DHO reversed at −75 mV, we hypothesized that it could come from an inhibition of K+ channels whose activity varies in parallel with the Na+-K+-ATPase activity. Supporting this hypothesis, the inward portion of this TEA+-sensitive current can be completely abolished by the addition of 1 mm Ba2+ to the bath. This study suggests that, in X. laevis oocytes, a close link exists between the Na-K-ATPase activity and TEA+-sensitive K+ currents and indicates that, in the absence of effective K+ channel inhibitors, I DHO does not exclusively represent the Na+-K+-ATPase-generated current.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00232521
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  • 7
    Electronic Resource
    Electronic Resource
    Solid/free-surface juncture boundary layer and wake (1998)
    Springer
    Experiments in fluids 25 (1998), S. 283-297 
    Details
    ISSN: 1432-1114
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  The Reynolds-averaged flow for a solid/free-surface juncture boundary layer and wake is documented. The three mean-velocity components and five of the Reynolds stresses are measured for a surface-piercing flat plate in a towing tank using a laser-Doppler velocimeter system for both boundary-layer and wake planes in regions close to the free surface. The experimental method is described, including the foil-plate model, laser-Doppler velocimeter system, conditions, and uncertainty analysis. The underlying flow data is in excellent agreement with benchmark data. Inner (near the plate and wake centerplane and below the free surface) and outer (near the free surface) regions of high streamwise vorticity of opposite sign are observed, which transport, respectively, high mean velocity and low turbulence from the outer to the inner and low mean velocity and high turbulence from the inner to the outer portions of the boundary layer and wake. For the wake, the inner region of vorticity is relatively weak. The physical mechanism for the streamwise vorticity is analyzed with regard to the Reynolds-averaged streamwise vorticity equation. The anisotropy of the crossplane normal Reynolds stresses closely correlates with the vorticity and, additionally, indicates similarity, i.e., its nature is such that it only depends on the proximity to the plate and free surface boundaries or wake centerplane symmetry plane. Free-surface effects on the Reynolds stresses are analyzed with regard to the behavior close to the free surface of the turbulent kinetic energy and the normal components of the anisotropy tensor and the anisotropy invariants. Close to the free surface, the turbulent kinetic energy is nearly constant and increases for the inner and outer portions, respectively, of the boundary layer and wake and the normal components of the anisotropy tensor and the anisotropy invariants roughly correspond to the limiting values for two-component turbulence. The similarities and differences between the present results and analysis with those from related studies are discussed. The data and analysis should have practical application with regard to the development of turbulence models for computational fluid dynamics methods for the Reynolds-averaged Navier–Stokes equations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003480050232
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  • 8
    Electronic Resource
    Electronic Resource
    180° domain wall with the coordinate dependent azimuthal angle of magnetization : The 40th annual conference on magnetism and magnetic materials (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 6060-6062 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Structure of 180° one-dimensional domain wall (DW) in a uniaxial ferromagnet in the presence of an external magnetic field arbitrarily oriented with respect to the DW has been investigated. Solutions of the system of equations which describe the behavior of the magnetic moment inside the DW in the case when the magnetization azimuthal angle is dependent upon the coordinate normal to the DW have been obtained and influence of magnetic field on the structure of the DW analyzed. Dependences of the effective widths of the distributions of both the polar and azimuthal angles of magnetization across the DW proper have been obtained. The effective width due to the azimuthal angle variation along the DW normal was found to increase with increasing transverse field. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.362091
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of biquadratic exchange coupling on magnetoresistance and magnetization process in magnetic bilayer systems (1999)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 85 (1999), S. 4430-4432 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: An improved model is proposed to deal with the magnetic bilayer systems taking into account the contribution of the anisotropy energy and biquadratic exchange coupling to elaborate on the evolution of the magnetoresistance (MR) ratio and magnetization process. The results indicate that the characteristic behavior of the MR ratio depends distinctly on both the biquadratic coupling constant and the layer thickness. The profile of the MR ratio was found to vary from an inverted bell shape to a concave pyramid with increasing biquadratic coupling strength, and decays sharply with the layer thickness. This model calculation helps us to provide a venue for further understanding the MR or giant magnetoresistance behavior of the magnetic multilayer system. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.370364
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  • 10
    Electronic Resource
    Electronic Resource
    Effects of stress on the growth of TiSi2 thin films on (001)Si (1999)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 74 (1999), S. 1406-1408 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Tensile stress induced by backside CoSi2 films on a silicon substrate has been found to enhance the growth of C54–TiSi2 on (001)Si. In contrast, compressive stress induced by backside oxide films on the silicon substrate was found to retard significantly the growth of C54–TiSi2 on (001)Si. For Ti on stressed (001)Si after rapid thermal annealing at 800 °C for 30 s, the thickness of the C54– TiSi2 films was found to increase and decrease with the tensile and compressive stress levels, respectively. The retarded growth is attributed to the hindrance of the migration of Si through the Ti/Si interface by the compressive stress. On the other hand, the presence of tensile stress promotes the Si diffusion to facilitate the formation of Ti silicide thin films. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.123565
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