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  • 1995-1999  (2)
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  • 1
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    Unknown
    [Investigation of tibial bones of the rats exposed on board "Spacelab-2":histomorphometric analysis] (1996)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: Proximal metaphyses of tibial bones from the Sprague-Dowly rats exposed in US dedicated space life sciences laboratory SLS-2 for 13-14 days and sacrificed on day 13 in microgravity and within 5 hours and 14 days following recovery were the subject of histological, histochemical, and histomorphometric analyses. After the 13-day flight of SLS-2 the rats showed initial signs of osteopenia in the spongy tissue of tibial bones, secondary spongiosis affected first. Resorption of the secondary spongiosis was consequent to enhanced resorption and inhibition of osteogenesis. In rats sacrificed within 5 hours of recovery manifestations of tibial osteopenia were more evident than in rats sacrificed during the flight. Spaceflight-induced changes in tibial spongiosis were reverse by character the amount of spongy bone was fully compensated and following 14 days of readaptation to the terrestrial gravity.
    Keywords: Aerospace Medicine
    Type: Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine (ISSN 0233-528X); Volume 30; 1; 21-6
    Format: text
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    NASA TECHNICAL REPORTS
  • 2
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    Unknown
    Histomorphometric study of tibia of rats exposed aboard American Spacelab Life Sciences 2 Shuttle Mission (1996)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: Tibial bones of rats flown onboard the SLS-2 shuttle mission were studied. Trabecular bone parameters were investigated, including growth plate height, trabecular bone volume, thickness and number, and trabecular separation in the primary and secondary spongiosa. Several histomorphometric changes were noted, allowing researchers to conclude that exposure to microgravity resulted in osteopenia of spongy bone of tibial metaphysis. The roles of bone formation and bone resorption are discussed.
    Keywords: Aerospace Medicine
    Type: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology (ISSN 1077-9248); Volume 3; 2; 80-1
    Format: text
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    NASA TECHNICAL REPORTS
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