ISSN:
0021-9304
Keywords:
radiochemical study
;
cholesteryl oleate, dioleoyl phosphatidylcholine
;
lysozyme
;
uptake by contact lens materials
;
artificial tear solutions
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
,
Technology
Notes:
Employing an artificial tear preparation composed of six proteins and six lipids as a deposit model, uptake of the lipids 3H-cholesteryl oleate and 14C-dioleoyl phosphatidylcholine was measured on contact lenses representative of the four FDA hydrogel groups and on select RGP lenses. Cholesteryl oleate uptake after 24 h at 37°C generally was less than 1 μg/lens although occasionally reaching 1-2 μg. DuraSoft 3 lenses (Group IV) accumulated the deposits in greater amounts (p = 0.04) with other lens groups not differing significantly from each other. Ionic DuraSoft 2 and 3 lenses bound more phosphatidylcholine (also 〈1 μg) than other lens groups, possibly reflecting an interaction between the positively charged choline residue and the negative surface of the lens. Lysozyme deposition, measured simultaneously with cholesteryl oleate, bound to a far greater extent to Group IV lenses (e.g., DuraSoft 3, mean surface deposit 279 μg) than to other lens types (p 〈 0.01). Multiple application of the artificial tear solution did not produce a statistically significant increase in cholesteryl oleate accumulation. © 1997 John Wiley & Sons, Inc. J Biomed Mater Res, 37, 207-211, 1997.
Additional Material:
5 Tab.
Type of Medium:
Electronic Resource
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