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  • 1995-1999  (502)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Microtribological Characterization of Self-Assembled and Langmuir-Blodgett Monolayers by Atomic and Friction Force Microscopy (1995)
    s.l. : American Chemical Society
    Langmuir 11 (1995), S. 3189-3198 
    Details
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/la00008a052
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  • 2
    Electronic Resource
    Electronic Resource
    Developmental regulation of presence of binding sites for neoglycoproteins and endogenous lectins in various embryonic stages of human lung, liver and heart (1995)
    Springer
    Development genes and evolution 204 (1995), S. 344-349 
    Details
    ISSN: 1432-041X
    Keywords: Development ; Lectin ; Neoglycoprotein Glycoconjugate ; Histochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Protein-carbohydrate interactions are supposed to play key roles in the mechanisms of cell adhesion, biosignalling and intracellular routing, warranting the analysis of the developmental course of expression of epitopes of this system. Thus, a panel of carrier-immobilized carbohydrate ligands was used as probes, namely lactose,N-acetylgalactosamine,N-acetylglucosamine, mannose, fucose and maltose. Additionally, an antibody to an endogenous β-galactoside-binding lectin (anti-galectin-1), the biotinylated lectin and two further human lectins, namely the macrophage migration inhibitory factor-binding sarcolectin and serum amyloid P component (SAP) that displays selectivity for sulphated sugars and mannose-6-phosphate, were included. They enabled us to assess the extent of the presence of respective binding sites in fixed sections from human lungs (pulmonary epithelial cells), livers (hepatocytes) and hearts (myocard cells) of 10–50 weeks gestation. Invariably, specific binding was detected in the three organ types, at least in certain stages. In most of the cases, the intensity of staining exhibited developmental regulation. The apparent patterns reveal similarities between the different cell types, as seen with immobilizedN-acetylglucosamine as well as with labelled galectin-1 and sarcolectin. However, drastic differences among such patterns with nearly opposite developmental courses do also occur, as detected for carrier-attached mannose and maltose residues. These results point to a potential importance for the detected glycohistochemical features in human development and substantiate the possibility of differential regulation of the presence of binding sites for distinct sugars within a certain organ and between the individual cell types of the monitored organs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02179503
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  • 3
    Electronic Resource
    Electronic Resource
    Verfahren zur Ermittlung der Eigenwertspektren und Zustandsformen von Energieversorgungsnetzen (1997)
    Springer
    Electrical engineering 80 (1997), S. 259-268 
    Details
    ISSN: 1432-0487
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Description / Table of Contents: Contents A method is presented which provides the spectrum of eigenvalues of electrical transmission networks and a corresponding set of state-equations. It is pointed out that the eigenvalues of transmission networks accumulate in few clusters. Based on the eigenvalues, a network is synthesized which leads to a set of state-equations. Using these equations, a considerable decrease of computing time is achieved.
    Notes: Übersicht Zunächst wird ein Berechnungsverfahren vorgestellt, mit dem Eigenwertspektren von Energieversorgungsnetzen zu ermitteln sind. Es zeigt sich, daß die Eigenwerte in Energieversorgungsnetzen Häufungsbereiche bilden. Darauf aufbauend wird ein Netzwerk synthetisiert, aus dem sich eine zugehörige Zustandsform bestimmen läßt. Diese Darstellung führt bei Simulationen von Zeitverläufen zu erheblichen Rechenzeitver kürzungen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01232798
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  • 4
    Electronic Resource
    Electronic Resource
    Non-existence of cohomogeneity one Einstein metrics (1999)
    Springer
    Mathematische Annalen 314 (1999), S. 109-125 
    Details
    ISSN: 1432-1807
    Keywords: Mathematics Subject Classification (1991):53C25, 34B15, 58E11
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002080050288
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  • 5
    Electronic Resource
    Electronic Resource
    Identifying chromosomal fragile sites from individuals: a multinomial statistical model (1995)
    Springer
    Human genetics 〈Berlin〉 95 (1995), S. 249-256 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The inability to identify fragile sites from data for single individuals remains the major obstacle to determining whether these chromosomal loci are predisposed to cancer-causing and evolutionary rearrangements. We describe a novel statistical model that is amenable to data from single individuals and that establishes site-specific chromosomal breakage as nonrandom with respect to the distribution of total breakage. Our method tests incrementally smaller subsets of the data for homogeneity under a multinomial model that assigns equal probabilites to a maximal set of nonfragile sites and unrestricted probabilities to the remaining fragile sites with significantly higher numbers of breaks. We show how standardized Pearson's chi-square (X 2) and likelihood-ratio (G 2) statistics can be appropriately used to measure goodness-of-fit for sparse contingency (individual-based) data in this model. A sample application of this approach indicates extensive variation in fragile sites among individuals and marked differences in fragile-site inferences from pooled as opposed to per-individual data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225189
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  • 6
    Electronic Resource
    Electronic Resource
    Transposon-induced splicing defect in the rat nude gene (1997)
    Springer
    Immunogenetics 45 (1997), S. 282-283 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050206
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  • 7
    Electronic Resource
    Electronic Resource
    Characterization of mouse and human nude genes (1997)
    Springer
    Immunogenetics 46 (1997), S. 509-515 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  The differentiation of primitive epithelial precursor cells in the thymic primordium into subcapsular, cortical, and medullary epithelial cells of the mature thymus requires the activity of the nude gene product Whn. Whn is also required for proper keratinization of the hair shaft. We determined the nucleotide sequence of a 58 kilobase region on mouse chromosome 11 that encompasses the mouse nude gene and part of the two neighboring genes, encoding a sodium/dicarboxylate co-transporter and the retinal protein 4. Using cross-hybridization, the human orthologue of the mouse nude gene was isolated. The human WHN protein also consists of 648 amino acids, 85% of which are identical to the mouse protein. Like the mouse gene, the human gene consists of eight coding exons and utilizes two alternative first exons in a tissue-specific fashion. Sequences upstream of the two alternative first exons display promoter activity in heterologous reporter assays. Whereas both promoters appear to be active in skin (albeit at different levels), only the most upstream element is active in the thymus, indicating that transcriptional activity of the whn gene is subject to complex regulation. Nucleotide sequence database comparisons reveal that among other winged-helix genes, the HTLF and HTLFL1 genes are most closely related to whn, although the exon/intron structure of the human HTLF gene in the DNA binding domain differs from that of whn.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050312
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  • 8
    Electronic Resource
    Electronic Resource
    An intragenic deletion in the human PTPN6 gene affects transcriptional activity (1995)
    Springer
    Human genetics 〈Berlin〉 95 (1995), S. 713-715 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract An intragenic deletion in the human PTPN6 gene is described. The PTPN6 gene maps to chromosome 12p12-13 and is shown to possess two alternative first exons. A 1.7-kb deletion occurring in the intron between the two alternatively used first exons is the result of an illegitimate recombination between two Alu-type repeats. The deletion increases the transcriptional activity of the distal promotor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00209495
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  • 9
    Electronic Resource
    Electronic Resource
    Direct molecular analysis of the fragile X syndrome in a sample of Egyptian and German patients using non-radioactive PCR and Southern blot followed by chemiluminescent detection (1995)
    Springer
    Human genetics 〈Berlin〉 96 (1995), S. 577-584 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Molecular genetic analysis of individuals from 6 Egyptian and 33 German families with fragile X syndrome and 240 further patients with mental retardation was performed applying a completely non-radioactive system. The aim of our study was the development of a non-radioactive detection method and its implementation in molecular diagnosis of the fragile X syndrome. Furthermore, we wanted to assess differences in the mutation sizes between Egyptian and German patients and between Egyptian and German carriers of a premutation. Using non-radioactive polymerase chain reaction (PCR), agarose gel electrophoresis and blotting of the PCR products, followed by hybridisation with a digoxigenin-labelled oligonucleotide probe (CGG)5 and chemiluminescent detection, we identified the fragile X full mutation (amplification of a CGG repeat in the FMR-1 gene ranging from several hundred to several thousand repeat units) in all patients. We observed no differences in the length of the CGG repeat between the Egyptian and German patients and carriers, respectively. However, in one prenatal diagnosis, we detected only one normal sized allele in a female fetus using the PCR-agarose assay, whereas Southern blot analysis with the digoxigenin labelled probe StB 12.3 revealed presence of a full mutation. Our newly established nonradioactive genomic blotting method is based on the conventional radioactive Southern blot analysis. Labelling of the probe StB 12.3 with digoxigenin via PCR allowed the detection of normal, premutated and fully mutated alleles. For exact sizing of small premutated or large normal alleles, we separated digoxigenin labelled PCR products through denaturing poly-acrylamide gelelectrophoresis (PAGE) and transfered them to a nylon membrane using a gel dryer. The blotted PCR-fragments can easily be detected with alkaline phosphate-labelled anti-digoxigenin antibody. The number of trinucleotide repeat units can be determined by scoring the detected bands against a digoxigenated M13 sequencing ladder. Our newly developed digoxigenin/chemiluminescence approach using PCR and Southern blot analysis provides reliable results for routine detection of full fragile X mutations and premutations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00197414
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  • 10
    Electronic Resource
    Electronic Resource
    A yeast artificial chromosome contig spanning the mouse immunoglobulin kappa light chain locus (1997)
    Springer
    Immunogenetics 45 (1997), S. 180-187 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  A single contig spanning the entire mouse immunoglobulin kappa light chain (Igk) locus on chromosome 6 has been established using yeast and bacterial artificial chromosome clones. Detailed mapping of the Igk locus indicates that a member of the Igk-V2 gene family, located about 3.5 megabases upstream of the Igk-J-C complex, is the most distal functional Igk-V gene. Sequence analyses of Igk-V genes and anonymous DNA segments provide indications for internal duplications at the 5′ end of the Igk-V locus and identify the likely origin of Igk-V orphon gene clusters located elsewhere in the mouse genome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050187
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