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  • Articles  (96)
  • Springer  (96)
  • 1995-1999  (58)
  • 1970-1974  (21)
  • 1920-1924  (1)
  • 1905-1909  (16)
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  • Articles  (96)
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  • 1
    ISSN: 1432-1432
    Keywords: Key words: Genome evolution — Adaptability — Somatic hypermutation — Affinity maturation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. Darwinian theory requires that mutations be produced in a nonanticipatory manner; it is nonetheless consistent to suggest that mutations that have repeatedly led to nonviable phenotypes would be introduced less frequently than others—if under appropriate genetic control. Immunoglobulins produced during infection acquire point mutations that are subsequently selected for improved binding to the eliciting antigen. We and others have speculated that an enhancement of mutability in the complementarity-determining regions (CDR; where mutations have a greater chance of being advantageous) and/or decrement of mutability in the framework regions (FR; where mutations are more likely to be lethal) may be accomplished by differential codon usage in concert with the known sequence specificity of the hypermutation mechanism. We have examined 115 nonproductively rearranged human Ig sequences. The mutation patterns in these unexpressed genes are unselected and therefore directly reflect inherent mutation biases. Using a χ2 test, we have shown that the number of mutations in the CDRs is significantly higher than the number of mutations found in the FRs, providing direct evidence for the hypothesis that mutations are preferentially targeted into the CDRs.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Immunogenetics 44 (1996), S. 485-486 
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' journal of analytical chemistry 357 (1997), S. 503-504 
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Starting with the high functionalized trisilane SiClMe(SiCl2Me)2 and tetrasilane SiMe(SiCl2Me)3 several octa- and decasilane dendrimers containing directly neighboured branchings were prepared. In these compounds the 29Si NMR chemical shifts of the different silyl groups are shifted towards lower field compared with those of analogous groups in tetra- or hexasilanes. This observation is a helpful tool for the characterization of further dendritic oligomers by 29Si NMR.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 10 (1973), S. 225-226 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Chromosoma 29 (1970), S. 462-473 
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Swarming locusts show three physical criteria, i.e. the phase changes of melanisation of the nymphal stages or hoppers, of the proportions of certain body parts (morphometric ratios), and increased genetic recombination (meiotic chiasma frequencies) in the adult. The control of these changes, initiated by aggregation into swarms, i.e. gregarisation, seems to be vested in a pheromone which is produced by all hoppers in both the solitaria and gregaria phases, also by hoppers of the albino strain. Such a pheromone can be extracted from the locust room air and from the locust, these extracts showing high activity in bioassays, primarily in increased chiasma frequencies but also in hopper colour. The extract in risella oil is more efficient than that in petroleum ether and can be distilled to yield an active distillate. The pheromone is secreted in the faeces of hoppers but not of adults. There is evidence in faeces bioassays that all three physical criteria are affected; the pheromone may be called locustone. It is manufactured or secreted in a specific section of the alimentary canal, i.e. the crop. Reception is not through the antennae but through the stigmata. Preliminary chemical analysis of a risella oil air extract distilled into various other solvents showed the presence of a relatively simple saturated aliphatic chain with a carbonyl function, perhaps a ketone or an ester.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 61 (1998), S. 175-181 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
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  • 7
    ISSN: 1573-482X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Thin films of iron pyrite (FeS2) have been prepared on glass and glassy carbon substrates by low pressure metal organic chemical vapour deposition (LP-MOCVD) using iron pentacarbonyl (Fe(CO)5) and di-tert.-butyldisulphide (TBDS) as precursors. The TBDS partial pressure was varied from 1 to 100 Pa for different iron pentacarbonyl partial pressures (0.25, 0.5 and 1 Pa) while all other parameters were maintained constant. It was found that there is a critical TBDS-partial pressure of about 30 Pa for a deposition temperature of 475 °C, where a drastic change in the layer properties occurs. Below this TBDS partial pressure pyrrhotite type phases (Fe1-xS) will be formed although there is a sulphur precursor excess in the gas phase. If the layers contain pyrrhotite, the electrical properties of the FeSx-films are changed significantly. The occurrence of the pyrrhotite phases does not depend on the growth rate, hence it is not controlled kinetically. Therefore, the sulphur pressure above the growing pyrite film is the important parameter controlling the solid phase. The present investigation shows that, in order to prepare pyrite thin films of good electronic quality, one has to take care to avoid the secondary sulphur-iron phases even in very small concentrations.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1435-0645
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Festuca rubra L. subsp. rubra cv. Cindy) and Chewings fescue (Festuca rubra L. subsp. commutata Gaudin cv. Center). Treatments were (i) straw residue removed and stubble flail-chopped (flail-chop), (ii) straw residue removed and stubble close-clipped and vacuum-swept (close-clip), (iii) straw residue removed and stubble propane-burned (propane-burn), and (iv) residue and stubble open-burned with full straw load (open-burn). Seed yield components were also measured, to identify the component through which treatments affected yield. Treatment effects on seed yield of both crops interacted with years. Averaged across years, creeping red fescue seed yield was 993, 903, 804, and 620 kg ha-1 for open-burn, propane-burn, close-clip, and flail-chop treatments, respectively. The greatest treatment effect was on number of panicles, and consequently on number of floret sites and seeds produced per unit area. The number of spikelets per panicle, florets per spikelet, and seeds produced per panicle were unaffected. Open-burn also resulted in the fewest weed seeds and the highest purity of the harvested seed. Treatments affected Chewings fescue seed yield in only one year, when seed yield was 750, 680, 477, and 553 kg ha-1 for open-burn, propane-burn, close-clip, and flail-chop treatments, respectively. Treatments did not affect the number of panicles or seeds produced per unit area in Chewings fescue, the number of weed seeds, or the purity of the harvested seed. We concluded that mechanical removal of postharvest residue in Chewings fescue can maintain seed yield and seed quality similar to open-burn. In contrast, open-burn is required to achieve maximum seed yield and seed quality in creeping red fescue.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Virtual reality 3 (1998), S. 187-199 
    ISSN: 1434-9957
    Keywords: Input devices ; Wearable computers ; Empirical study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract This paper reports on an experiment investigating the functionality and usability of novel input devices on a wearable computer for text entry tasks. Over a 3-week period, 12 subjects used three different input devices to create and save short textual messages. The virtual keyboard, forearm keyboard, and Kordic keypad input devices were assessed for their efficiency and usability in simple text-entry tasks. Results collected included the textual data created by the subjects, the duration of activities, the survey data and observations made by supervisors. The results indicated that the forearm keyboard is the best performer for accurate and efficient text entry while other devices may benefit from more work on designing specialist graphical user interfaces (GUIs) for the wearable computer.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Environmental management 20 (1996), S. 865-872 
    ISSN: 1432-1009
    Keywords: KEY WORDS: Biodiversity; Ecosystem management; Ecological stewardship; Sustainable development; Assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
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