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  • American Association for the Advancement of Science (AAAS)
  • 1995-1999  (1)
  • 1980-1984  (1)
  • 1950-1954
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  • 1
    Publication Date: 1997-06-20
    Description: Kaposi's sarcoma-associated herpesvirus (KSHV) was found in the bone marrow dendritic cells of multiple myeloma patients but not in malignant plasma cells or bone marrow dendritic cells from normal individuals or patients with other malignancies. In addition the virus was detected in the bone marrow dendritic cells from two out of eight patients with monoclonal gammopathy of undetermined significance (MGUS), a precursor to myeloma. Viral interleukin-6, the human homolog of which is a growth factor for myeloma, was found to be transcribed in the myeloma bone marrow dendritic cells. KSHV may be required for transformation from MGUS to myeloma and perpetuate the growth of malignant plasma cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rettig, M B -- Ma, H J -- Vescio, R A -- Pold, M -- Schiller, G -- Belson, D -- Savage, A -- Nishikubo, C -- Wu, C -- Fraser, J -- Said, J W -- Berenson, J R -- New York, N.Y. -- Science. 1997 Jun 20;276(5320):1851-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Hematology and Oncology, Veterans Affairs West Los Angeles Medical Center, Los Angeles, CA 90073, USA. RETTIG.MATTHEW@WEST-LA.VA.GOV〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9188529" target="_blank"〉PubMed〈/a〉
    Keywords: Blotting, Southern ; Bone Marrow/pathology/*virology ; Cell Transformation, Neoplastic ; DNA, Viral/analysis ; Dendritic Cells/*virology ; HL-60 Cells ; Herpesvirus 8, Human/genetics/isolation & purification/*pathogenicity/physiology ; Humans ; In Situ Hybridization ; Interleukin-6/*analysis/genetics/physiology ; Multiple Myeloma/pathology/*virology ; Paraproteinemias/pathology/virology ; Polymerase Chain Reaction ; Stromal Cells/pathology/virology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1980-12-12
    Description: Vasoactive intestinal peptide, a smooth-muscle relaxant neuropeptide with neurotransmitter properties, was relaxed during electrical field stimulation of guinea pig trachea. The amount released correlated with the degree of relaxation, and the release was blocked by tetrodotoxin. Prior incubation of the trachea with antiserum to vasoactive intestinal peptide reduced the relaxation. Thus vasoactive intestinal peptide may mediate the nonadrenergic relaxation of tracheal smooth muscle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matsuzaki, Y -- Hamasaki, Y -- Said, S I -- HL-14187/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1980 Dec 12;210(4475):1252-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6254154" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/*physiology ; Animals ; Antigen-Antibody Reactions ; Electric Stimulation ; Female ; Gastrointestinal Hormones/*physiology ; Humans ; Mice ; *Muscle Contraction ; *Muscle Relaxation ; Muscle, Smooth/drug effects ; Neural Inhibition ; Synaptic Transmission ; Tetrodotoxin/pharmacology ; Trachea/*innervation ; Vasoactive Intestinal Peptide/immunology/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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