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  • 1995-1999  (43)
  • 1960-1964  (11)
  • 1
    ISSN: 1432-1769
    Keywords: Proteus ; INSIGHT ; Reconfigurable computational network ; MIMD ; Enhanced hypercube ; Parallel computing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract The Proteus architecture is a highly parallel, multiple instruction, multiple data machine (MIMD) optimized for large granularity tasks such as machine vision and image processing. The system can achieve 20 gigaflops (80 gigaflops peak). It accepts data via multiple serial links at a rate of up to 640 MB/S. The system employs a hierarchical reconfigurable interconnection network with the highest level being a circuit-switchedenhanced hypercube, serial interconnection network for internal data transfers. The system is designed to use 256 to 1024 RISC processors. The processors use 1-MB externalread/write allocating caches for reduced multiprocessor contention. The system detects, locates, and replaces faulty subsystems using redundant hardware to facilitatefault tolerance. The parallelism is directly controllable through an advanced software system for partitioning, scheduling, and development. System software includes a translator for the INSIGHT language, a parallel debugger, lowand high-level simulators, and a message-passing system for all control needs. Image-processing application software includes a variety of point operators, neighborhood operators, convolution, and the mathematical morphology operations of binary and gray-scale dilation, erosion, opening, and closing.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Biological cybernetics 77 (1997), S. 79-87 
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract.  There have been various descriptions of cerebellar function in terms of adaptive control. However, a number of recent publications have indicated that the cerebellum is involved in a range of cognitive processes including pure cognitive activity. This review paper relates the concept of cerebellar adaptive control to cerebellar cognition, and explores the relative roles of the cerebrum and cerebellum by considering the issue of representation and processing of information in a systematic manner. It is suggested that the cerebellar cortex and cerebral cortex facilitate two fundamentally different types of information representation and processing which are complementary and which should be able to reciprocally evaluate and correct each other, thereby providing the basis for a self-correcting adaptive control system.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 65 (1961), S. 1658-1659 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd.
    Fatigue & fracture of engineering materials & structures 21 (1998), S. 0 
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Stress-corrosion cracking (SCC) involves the interaction between stress and the environment to cause cracking in situations where if present independently their effect would be benign. SCC involves mechanics through the role of stress and the material through its interaction with the environment. SCC has occurred in many engineering structures, generally without expectation that a specific combination of material and environment would produce such cracking. This paper discusses SCC and the development of models to quantify its effect on the life of structures—outlining both the approach and inherent complications due to the coupled mechanics and materials issues. This development is illustrated with reference to characterizing the initiation and early growth of SCC as it occurs on gas-transmission pipelines. The discussion closes with consideration of failure criteria for use in this application, which involves the coalescence of several cracks with the rather complex patches of cracks that occur with SCC in this application. Areas needing further attention are identified.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 19 (1996), S. 0 
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract— Multiple cracks are often observed in engineering structures; and their interaction and coalescence may significantly affect the lifetime of component or structure. In this paper, the general features associated with crack interaction and coalescence are presented, and the conditions for coalescence in various forms are reviewed. A model has been developed based on the principles of mixed mode fracture mechanics, to provide a rational explanation for the phenomenon of crack interaction and to predict the coalescence conditions. The latter is found to agree reasonably with the experimental observations.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 19 (1996), S. 0 
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract— Multiple cracks are often observed in engineering structures; and their interaction and coalescence may significantly affect the lifetime of a component or structure. In this paper, the general features associated with crack interaction and coalescence are presented, and the conditions for coalescence in various forms are reviewed. A model has been developed based on the principles of mixed mode fracture mechanics, to provide a rational explanation for the phenomenon of crack interaction and to predict the coalescence conditions. The latter is found to agree reasonably with the experimental observations.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Pharmaceutical research 13 (1996), S. 1210-1212 
    ISSN: 1573-904X
    Keywords: colonic delivery ; pectin ; ethylcellulose ; film coating ; enzymic degradation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. The purpose of the study was to investigate the potential of pectin, ethylcellulose combinations as a practical film coating for colonic delivery. Methods. Combinations of pectin and ethylcellulose, in the form of an aqueous dispersion, were used as coating formulations. Paracetamol cores were used as the substrate. The coatings were assessed by a flow through dissolution system simulating in vivo conditions by changes in pH and residence time. Pectinolytic enzymes were used to simulate the bacterial flora of the colon. Results. Drug release was controlled by the ratio of ethylcellulose to pectin in the film coat. Increasing the proportion of ethylcellulose and increasing the coat weight reduced drug release in pHl and pH7.4 media. The addition of pectinolytic enzymes to pH6 media increased the release of drug. Conclusions. Combinations of ethylcellulose and pectin can provide protection to a drug in the upper g.i. tract while allowing enzymatic breakdown and drug release in the colon.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 375 (1995), S. 318-322 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Using homologous recombination in embryonic stem (ES) cells, we inactivated the mouse EKLF gene by replacing a portion of the zinc-finger DNA-binding domain with a neomycin-resistance neoR cassette (Fig. la). ES cells with a targeted allele (Fig. \b) were used to generate ...
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 203 (1964), S. 593-596 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] DJORDJEVIC and Szybalski1 demonstrated that mammalian cells are sensitized to the killing action (defined as loss of ability to divide indefinitely) of X-rays if grown in media containing 5-bromodeoxyuridine (BUDR) under conditions where part of the thymine in DNA is replaced by 5-bromouracil (BU). ...
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-0417
    Keywords: lake levels ; Lake Erie ; Lake Wainfleet ; Niagara Gorge ; Niagara River ; Niagara Peninsula palyonology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences
    Notes: Abstract Over the last 12 600 years, lake levels in the eastern Lake Erie basin have fluctuated dramatically, causing major changes in drainage patterns, flooding and draining ephemeral Lake Wainfleet several times and widening and narrowing the Niagara Gorge as the erosive effects of Niagara Falls waxed and waned. The control sill for Lake Erie levels was at first the Fort Erie/Buffalo sill, before the Lyell/Johnson sill in Niagara Falls took over due to isostatic rebound. This sill, in time, was eventually eroded by the recession of Niagara Falls and the Fort Erie/Buffalo sill regained control. The environmental picture is complicated by catastrophic outbursts from glacial Lake Agassiz and Lake Barlow-Ojibway, changes in outlet routes, isostatic rebound and climatic changes over the Great Lakes basins. Today, the flow of water into Lake Erie from the streams and rivers surrounding it only accounts for about 13% of the flow out of it, therefore, the importance of flow from the Upper Great Lakes, specifically the flow from Lake Huron, has a great effect on Lake Erie levels. While the changing control sills, Lyell/Johnson and Buffalo/Fort Erie would affect Lake Erie levels, overall they are mostly input driven by the amount of waters received from the Upper Great Lakes. Since Lake Erie's water level changes are so closely tied to Lake Huron's water level changes we have decided to use names assigned to Lake Huron such as the two Mattawa highstands and three Stanley lowstands rather than inflict a whole new set of names on the public. While the duration of each high and lowstand in Erie and Huron may not always be the same, they always happen within the same time frame. The datum elevations used for Lake Huron (175.8 m) and Lake Erie (173.3 m) are historically recorded averages. The Lake Erie levels proposed in this paper reflect Lake Hurons effects on Lake Erie and the levels occuring at the eastern end of the Erie Basin throughout the last 12 600 years. All dates in this paper are uncorrected 14 C dates unless the date was obtained from shells, then the date has been corrected for hard-water effects. Also, all heights are given as modern day elevations and are not adjusted for isostatic rebound.
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