ISSN:
1573-3904
Keywords:
amphiphilic amino acid
;
endomorphin-2
;
α-hydroxymethylphenylalanine
;
α-hydroxymethyltyrosine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Novel endomorphin-2 analogs containing the unusual amphiphilic amino acid (R)- and (S)-α-hydroxymethyltyrosine in position 1 and (R)- and (S)-α-hydroxymethylphenylalanine in the positions 3 and 4 were synthesized via the solid-phase method. The binding characteristics of the synthetic analogs may suggest that α-hydroxymethyl substitution of aminoacid residues influences the conformation of a peptide much more than simply increasing the local amphiphilic character of the peptide.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008906527082
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