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  • 2000-2004  (69)
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  • 1
    Publication Date: 2002-08-24
    Description: The mammalian ovarian follicle consists of a multilayered complex of somatic cells that surround the oocyte. A signal from the follicle cells keeps the oocyte cell cycle arrested at prophase of meiosis I until luteinizing hormone from the pituitary acts on the follicle cells to release the arrest, causing meiosis to continue. Here we show that meiotic arrest can be released in mice by microinjecting the oocyte within the follicle with an antibody that inhibits the stimulatory heterotrimeric GTP-binding protein Gs. This indicates that Gs activity in the oocyte is required to maintain meiotic arrest within the ovarian follicle and suggests that the follicle may keep the cell cycle arrested by activating Gs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mehlmann, Lisa M -- Jones, Teresa L Z -- Jaffe, Laurinda A -- New York, N.Y. -- Science. 2002 Aug 23;297(5585):1343-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of Connecticut Health Center, Farmington, CT 06032, USA. lmehlman@neuron.uchc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12193786" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies/immunology ; Cells, Cultured ; Cyclic AMP/metabolism ; Female ; GTP-Binding Protein alpha Subunits, Gi-Go/immunology/physiology ; GTP-Binding Protein alpha Subunits, Gs/antagonists & ; inhibitors/immunology/*physiology ; Hypoxanthine/pharmacology ; *Meiosis ; Mice ; Oocytes/drug effects/metabolism/*physiology ; Ovarian Follicle/*physiology ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2000-12-23
    Description: The apolipoprotein E (APOE) gene is the only genetic risk factor that has so far been linked to risk for late-onset Alzheimer's disease (LOAD). However, 50 percent of Alzheimer's disease cases do not carry an APOE4 allele, suggesting that other risk factors must exist. We performed a two-stage genome-wide screen in sibling pairs with LOAD to detect other susceptibility loci. Here we report evidence for an Alzheimer's disease locus on chromosome 10. Our stage one multipoint lod score (logarithm of the odds ratio for linkage/no linkage) of 2.48 (266 sibling pairs) increased to 3.83 in stage 2 (429 sibling pairs) close to D10S1225 (79 centimorgans). This locus modifies risk for Alzheimer's disease independent of APOE genotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Myers, A -- Holmans, P -- Marshall, H -- Kwon, J -- Meyer, D -- Ramic, D -- Shears, S -- Booth, J -- DeVrieze, F W -- Crook, R -- Hamshere, M -- Abraham, R -- Tunstall, N -- Rice, F -- Carty, S -- Lillystone, S -- Kehoe, P -- Rudrasingham, V -- Jones, L -- Lovestone, S -- Perez-Tur, J -- Williams, J -- Owen, M J -- Hardy, J -- Goate, A M -- AG16208/AG/NIA NIH HHS/ -- AG5681/AG/NIA NIH HHS/ -- U24 AG021886/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2000 Dec 22;290(5500):2304-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11125144" target="_blank"〉PubMed〈/a〉
    Keywords: Age of Onset ; Aged ; Alleles ; Alzheimer Disease/*genetics ; Apolipoprotein E4 ; Apolipoproteins E/genetics ; Chromosomes, Human, Pair 10/*genetics ; Genetic Linkage ; Genetic Markers ; *Genetic Predisposition to Disease ; Genotype ; Humans ; Lod Score ; Nuclear Family ; Odds Ratio
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2002-07-20
    Description: The continuing drive by the semiconductor industry to fabricate smaller structures using photolithography will soon require dimensional control at length scales comparable to the size of the polymeric molecules in the materials used to pattern them. The current technology, chemically amplified photoresists, uses a complex reaction-diffusion process to delineate patterned areas with high spatial resolution. However, nanometer-level control of this critical process is limited by the lack of direct measurements of the reaction front. We demonstrate the use of x-ray and neutron reflectometry as a general method to measure the spatial evolution of the reaction-diffusion process with nanometer resolution. Measuring compositional profiles, provided by deuterium-labeled reactant groups for neutron scattering contrast, we show that the reaction front within the material is broad rather than sharply defined and the compositional profile is altered during development. Measuring the density profile, we directly correlate the developed film structure with that of the reaction front.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, Eric K -- Soles, Christopher L -- Goldfarb, Dario L -- Trinque, Brian C -- Burns, Sean D -- Jones, Ronald L -- Lenhart, Joseph L -- Angelopoulos, Marie -- Willson, C Grant -- Satija, Sushil K -- Wu, Wen-Li -- New York, N.Y. -- Science. 2002 Jul 19;297(5580):372-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Polymers Division and, Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899-8541, USA. eric.lin@nist.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12130778" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2001-12-26
    Description: Stem cells generate many differentiated, short-lived cell types, such as blood, skin, and sperm, throughout adult life. Stem cells maintain a long-term capacity to divide, producing daughter cells that either self-renew or initiate differentiation. Although the surrounding microenvironment or "niche" influences stem cell fate decisions, few signals that emanate from the niche to specify stem cell self-renewal have been identified. Here we demonstrate that the apical hub cells in the Drosophila testis act as a cellular niche that supports stem cell self-renewal. Hub cells express the ligand Unpaired (Upd), which activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway in adjacent germ cells to specify self-renewal and continual maintenance of the germ line stem cell population.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kiger, A A -- Jones, D L -- Schulz, C -- Rogers, M B -- Fuller, M T -- GM07790-22/GM/NIGMS NIH HHS/ -- HD07493/HD/NICHD NIH HHS/ -- P01-DK53074/DK/NIDDK NIH HHS/ -- R01 GM078176/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2001 Dec 21;294(5551):2542-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5329, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11752574" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cell Division ; Cell Lineage ; Cues ; DNA-Binding Proteins/genetics/*metabolism ; Drosophila/cytology/embryology/genetics/*physiology ; Drosophila Proteins/*metabolism ; Germ Cells/*physiology ; Glycoproteins/*metabolism ; Janus Kinases ; Ligands ; Male ; Mutation ; Protein-Tyrosine Kinases/genetics/*metabolism ; STAT Transcription Factors ; Signal Transduction ; Spermatocytes/cytology/physiology ; Spermatogenesis ; Stem Cells/cytology/*physiology ; Testis/cytology/metabolism ; Trans-Activators/genetics/*metabolism ; *Transcription Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2004-04-17
    Description: The availability of iron is known to exert a controlling influence on biological productivity in surface waters over large areas of the ocean and may have been an important factor in the variation of the concentration of atmospheric carbon dioxide over glacial cycles. The effect of iron in the Southern Ocean is particularly important because of its large area and abundant nitrate, yet iron-enhanced growth of phytoplankton may be differentially expressed between waters with high silicic acid in the south and low silicic acid in the north, where diatom growth may be limited by both silicic acid and iron. Two mesoscale experiments, designed to investigate the effects of iron enrichment in regions with high and low concentrations of silicic acid, were performed in the Southern Ocean. These experiments demonstrate iron's pivotal role in controlling carbon uptake and regulating atmospheric partial pressure of carbon dioxide.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coale, Kenneth H -- Johnson, Kenneth S -- Chavez, Francisco P -- Buesseler, Ken O -- Barber, Richard T -- Brzezinski, Mark A -- Cochlan, William P -- Millero, Frank J -- Falkowski, Paul G -- Bauer, James E -- Wanninkhof, Rik H -- Kudela, Raphael M -- Altabet, Mark A -- Hales, Burke E -- Takahashi, Taro -- Landry, Michael R -- Bidigare, Robert R -- Wang, Xiujun -- Chase, Zanna -- Strutton, Pete G -- Friederich, Gernot E -- Gorbunov, Maxim Y -- Lance, Veronica P -- Hilting, Anna K -- Hiscock, Michael R -- Demarest, Mark -- Hiscock, William T -- Sullivan, Kevin F -- Tanner, Sara J -- Gordon, R Mike -- Hunter, Craig N -- Elrod, Virginia A -- Fitzwater, Steve E -- Jones, Janice L -- Tozzi, Sasha -- Koblizek, Michal -- Roberts, Alice E -- Herndon, Julian -- Brewster, Jodi -- Ladizinsky, Nicolas -- Smith, Geoffrey -- Cooper, David -- Timothy, David -- Brown, Susan L -- Selph, Karen E -- Sheridan, Cecelia C -- Twining, Benjamin S -- Johnson, Zackary I -- New York, N.Y. -- Science. 2004 Apr 16;304(5669):408-14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Moss Landing Marine Laboratories, 8272 Moss Landing Road, Moss Landing, CA 95039-9647, USA. coale@mlml.calstate.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15087542" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere ; Biomass ; Carbon/analysis/*metabolism ; Carbon Dioxide/analysis/metabolism ; Chlorophyll/analysis ; Diatoms/growth & development/metabolism ; Ecosystem ; *Iron/analysis/metabolism ; Nitrates/analysis/metabolism ; Nitrogen/analysis/metabolism ; Oceans and Seas ; Photosynthesis ; Phytoplankton/*growth & development/metabolism ; Seawater/chemistry ; *Silicic Acid/analysis/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2003-09-13
    Description: Stem cell self-renewal can be specified by local signals from the surrounding microenvironment, or niche. However, the relation between the niche and the mechanisms that ensure the correct balance between stem cell self-renewal and differentiation is poorly understood. Here, we show that dividing Drosophila male germline stem cells use intracellular mechanisms involving centrosome function and cortically localized Adenomatous Polyposis Coli tumor suppressor protein to orient mitotic spindles perpendicular to the niche, ensuring a reliably asymmetric outcome in which one daughter cell remains in the niche and self-renews stem cell identity, whereas the other, displaced away, initiates differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamashita, Yukiko M -- Jones, D Leanne -- Fuller, Margaret T -- 1P01 DK53074/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2003 Sep 12;301(5639):1547-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5329, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12970569" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Arabidopsis Proteins ; Cadherins/metabolism ; Calcium-Binding Proteins/*metabolism ; Cell Count ; Cell Differentiation ; *Cell Division ; Cell Polarity ; Centrosome/*physiology ; Cytoskeletal Proteins/metabolism ; Drosophila/*cytology/genetics/physiology ; Drosophila Proteins/*metabolism ; Germ Cells/cytology/*physiology ; Homeodomain Proteins/genetics/physiology ; Male ; Mutation ; Spindle Apparatus/physiology ; Stem Cells/cytology/*physiology ; Testis/cytology ; Trans-Activators/metabolism ; Tubulin/metabolism ; Tumor Suppressor Proteins/*metabolism ; beta Catenin
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2001-01-01
    Print ISSN: 0149-1423
    Electronic ISSN: 1943-2674
    Topics: Geosciences
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  • 8
    Publication Date: 2000-01-01
    Print ISSN: 0149-1423
    Electronic ISSN: 1943-2674
    Topics: Geosciences
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  • 9
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
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  • 10
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Journal of metastable and nanocrystalline materials Vol. 13 (Jan. 2002), p. 211-216 
    ISSN: 1422-6375
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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