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  • 1
    Electronic Resource
    Electronic Resource
    Virulence genes in the pathogenic yeast Candida albicans (2001)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology reviews 25 (2001), S. 0 
    Details
    ISSN: 1574-6976
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: In recent years, the incidence of fungal infections has been rising all over the world. Although the amount of research in the field of pathogenic fungi has also increased, there is still a need for the identification of reliable determinants of virulence. In this review, we focus on identified Candida albicans genes whose deletant strains have been tested in experimental virulence assays. We discuss the putative relationship of these genes to virulence and also outline the use of new different systems to examine the precise effect in virulence of different genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6976.2001.tb00577.x
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  • 2
    Electronic Resource
    Electronic Resource
    Uniqueness of complete spacelike hypersurfaces of constant mean curvature in generalized Robertson-Walker spacetimes (1995)
    Springer
    General relativity and gravitation 27 (1995), S. 71-84 
    Details
    ISSN: 1572-9532
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A new technique is introduced in order to solve the following question:When is a complete spacelike hypersurface of constant mean curvature in a generalized Robertson-Walker spacetime totally umbilical and a slice? (Generalized Robertson-Walker spacetimes extend classical Robertson-Walker ones to include the cases in which the fiber has not constant sectional curvature.) First, we determine when this hypersurface must be compact. Then, all these compact hypersurfaces in (necessarily spatially closed) spacetimes are shown to be totally umbilical and, except in very exceptional cases, slices. This leads to proof of a new Bernstein-type result. The power of the introduced tools is also shown by reproving and extending several known results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02105675
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  • 3
    Electronic Resource
    Electronic Resource
    On the Geometry of Generalized Robertson-Walker Spacetimes: Geodesics (1998)
    Springer
    General relativity and gravitation 30 (1998), S. 915-932 
    Details
    ISSN: 1572-9532
    Keywords: GENERALIZED ROBERTSON-WALKER SPACETIME ; GEODESIC CONNECTEDNESS ; GEODESIC COMPLETENESS ; STABILITY OF COMPLETENESS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The geometry and, especially, the geodesics of a class of spacetimes generalizing Robertson-Walker ones (without any assumption on the fiber) is studied, under a global point of view. Our study covers geodesic connectedness, geodesic completeness and stability of completeness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026664209847
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  • 4
    Electronic Resource
    Electronic Resource
    Geodesic Connectedness in Generalized Reissner-Nordström Type Lorentz Manifolds (1997)
    Springer
    General relativity and gravitation 29 (1997), S. 1023-1037 
    Details
    ISSN: 1572-9532
    Keywords: LORENTZ METRICS ; GEODESIC CONNECTEDNESS ; REISSNER-NORDSTRÖM SPACETIME ; CAUSALITY
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A detailed study of the existence, causal character and multiplicity of geodesics joining two points is carried out for a wide family of non-static Lorentz manifolds (including intermediate Reissner-Nordström, inner Schwarzschild and Generalized Robertson-Walker spacetimes). Results relating causality and connectedness by timelike or lightlike geodesics are obtained, in the spirit of the well-known Avez-Seifert result. The existence of closed spacelike geodesics is also characterized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018824709846
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  • 5
    Electronic Resource
    Electronic Resource
    New Di- and Trinuclear Complexes with Pyrazolato Bridges. Crystal Structures of [{(C6F5)2Pd(μ-pz)(μ-Cl)}2Pd]2- and [(C6F5)2Pd(μ-pz)2Pd(η3-C4H7)] (pz = pyrazolate) (2000)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 2000 (2000), S. 943-949 
    Details
    ISSN: 1434-1948
    Keywords: Pyrazolate complexes ; Palladium ; Platinum ; N ligands ; Bridging ligands ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Trinuclear complexes containing pyrazolate bridging ligands of the type [NBu4]2[{(C6F5)2 M(μ-pz)(μ-X)}2M′] (M, M′= Pd or Pt; X = Cl, OH, or pz) (Hpz = pyrazole) have been prepared using [NBu4][M(C6F5)2(acac)] (acac = acetylacetonate) or [NBu4]2[M2(C6F5)4(μ-OH)2] and [M′Cl2(Hpz)2] or [M′(Hpz)4]2+ as starting materials. Asymmetric homo- and heterobimetallic complexes of the types [NBu4][R2M(μ-pz)2Pd(η3-allyl)] and [R2M(μ-pz)2M′L2] (allyl = C3H5 or C4H7; L2 = 2 PEt3 or bipy; R = C6F5 or C6Cl5; M, M′ = Pd or Pt) have been obtained starting from [NBu4][MR2(pzHpz)] and [Pd(η3-allyl)(acac)] or [M′L2Cl2], respectively. The identity of the new complexes has been established by NMR (1H, 19F and 31P) spectroscopy. The crystal structure of [{(C6F5)2Pd(μ-pz)(μ-Cl)}2Pd]2- has an inversion centre, with a bent appearance of the Pd3(μ-pz)2(μ-Cl)2 moiety. The crystal structure of [(C6F5)2Pd(μ-pz)2Pd(η3-C4H7)] has also been determined by single-crystal X-ray diffraction, where a boat conformation of the central “Pd2N4” six-membered rings is observed.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    The complete sequence of a 9037 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 11 (1995), S. 587-591 
    Details
    ISSN: 0749-503X
    Keywords: yeast genome ; chromosome VII ; histidine permease ; glyceraldehyde-3-phosphate dehydrogenase ; pyruvate dehydrogenase ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: We report the sequence of a 9037 bp fragment from the right arm of Saccharomyces cerevisiae chromosome VII. Analysis of the sequence revealed four complete open reading frames (ORFs), namely G7572, G7576, G7579 and G7584. The first three corresponded, respectively, to the previously cloned genes: HIP1, coding for a high-affinity histidine-specific permease, TDH1, one of the known genes coding for glyceraldehyde-3-phosphate dehydrogenase and ODPX, which encodes a precursor of protein X, a component of the pyruvate dehydrogenase complex. The ORF G7584 showed 35·8% identity with a hypothetical protein of Caenorhabditis elegans chromosome 3. The reported sequence has been deposited in the EMBL data library under Accession Number X82408.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320110609
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  • 7
    Electronic Resource
    Electronic Resource
    The deletion of six ORFs of unknown function from Saccharomyces cerevisiae chromosome VII reveals two essential genes: YGR195w and YGR198w (1998)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 14 (1998), S. 853-860 
    Details
    ISSN: 0749-503X
    Keywords: Saccharomyces cerevisiae ; chromosome VII ; ribonuclease PH ; HGH1 ; YGR187c ; YGR189c ; YGR194c ; YGR195w ; YGR196c ; YGR198w ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: We have deleted six different ORFs of unknown function located on the right arm of Saccharomyces cerevisiae chromosome VII; namely, YGR187c/HGH1, YGR189c, YGR194c, YGR195w, YGR196c and YGR198w. No basic phenotypes could be attributed to the strains deleted in any of genes YGR187c/HGH1, YGR189c, YGR194c and YGR196c. These deletants did not show mating, sporulation or growth defects under any of the conditions tested. However, spores bearing deletions in either the YGR195w or YGR198w genes were unable to develop into macroscopical colonies. The YGR195w gene product shows significant homology with bacterial ribonuclease PH, an enzyme hitherto undescribed in yeasts, and its deletion causes a loss of viability after one to three rounds of cell division. Overexpression of this gene, using a tetracycline-regulatable promoter system, did not cause any effect on the cells. Contrary to what has been reported for prokaryotic homologs, this enzyme could play an essential role in yeast cell biology. The product encoded by the other essential ORF, YGR198w, shows no significant homology with any protein of known function in the databases. Spores bearing the deletion usually germinate and give rise to microcolonies of 50-100 non-viable cells. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Cloning of Candida albicans SEC14 gene homologue coding for a putative essential function (1996)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 12 (1996), S. 1097-1105 
    Details
    ISSN: 0749-503X
    Keywords: SEC14 ; Candida albicans ; protein secretion ; pathogenic fungi ; PI-TP ; Life Sciences ; Life Sciences (general)
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The yeast SEC14 gene product is required for the transport of proteins from the Golgi complex. We have cloned the homologous Candida albicans SEC14 gene (CaSEC14) by functional complementation of a Saccharomyces cerevisiae thermosensitive mutant, sec14. Some putative TATA boxes have been identified in CaSEC14 and, contrary to S. cerevisiae SEC14, no introns were found in the Candida homologue. Sequence analysis revealed that CaSec14p is a 301 amino acid protein, 67% identical to S. cerevisiae and Kluyveromyces lactis Sec14p, and 61% identical to the 300 amino-terminal residues of Yarrowia lipolytica Sec14p. Hydrophatic profile analysis of CaSec14p suggests a soluble protein without transmembrane domains, as has been described for the S. cerevisiae counterpart. While it was easy to disrupt one allele of SEC14 in C. albicans, repeated attempts to disrupt the second allele were unsuccessful, thus suggesting that the gene could be essential for vegetative growth in C. albicans. The sequence has been deposited in the EMBL data library under Accession Number X81937.
    Additional Material: 4 Ill.
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  • 9
    Electronic Resource
    Electronic Resource
    DNA Sequence Analysis of a 23 002 bp DNA Fragment of the Right Arm of Saccharomyces cerevisiae Chromosome VII (1997)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 13 (1997), S. 357-363 
    Details
    ISSN: 0749-503X
    Keywords: Saccharomyces cerevisiae ; yeast genome ; genome sequencing ; chromosome VII ; QCR9 ; UBR1 ; TYS1 ; TFG1 ; HGH1 ; BUB1 ; tRNALeu3 ; tRNATrp ; tRNALys1 ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: We report the sequence of a 23 002 bp fragment located on the right arm of Saccharomyces cerevisiae chromosome VII. Analysis of this region revealed 14 complete open reading frames (ORFs) with more than 300 base pairs. Six of them correspond to previously known genes. G7164 is the QCR9 gene coding for subunit 9 of the cytochrome c reductase; G7168 is UBR1, encoding an ubiquitin protein ligase; G7522 is the TYS1 gene, which encodes for the tyrosyl tRNA synthetase; G7526 is TFG1, the gene coding for the RNA polymerase transcription initiation factor TFIIF (factor G); G7538 is the gene HGH1 which encodes a protein related to the mammalian HMG1 and HMG2 proteins. G7542 is the BUB1 gene which encodes a ser/thr protein kinase involved in spindle assembly during the cell cycle. One of the ORFs, G7553, shares significant homologies with the gene UTR2 from S. cerevisiae. None of the seven remaining ORFs shows similarity to any of the sequences within the public databases. Three ORFs are internal ORFs of the above-described known genes, and two small ORFs are completely contained in larger ORFs on the complementary strand, and therefore probably do not correspond to real genes. This region also contains three genes specifying tRNAs for Leu, Lys and Trp, and several LTR elements. The sequence described in this paper has been deposited in the EMBL data library under the Accession Number X99074. © 1997 John Wiley & Sons, Ltd.
    Additional Material: 3 Ill.
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  • 10
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    Effects of Natural Cyclodextrins on the Photophysical Properties of Dibenzofuran-2-carboxylic Acid (2004)
    American Chemical Society
    Details
    Publication Date: 2004-01-01
    Print ISSN: 1089-5639
    Electronic ISSN: 1520-5215
    Topics: Chemistry and Pharmacology , Physics
    Published by American Chemical Society
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