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  • 1
    Monographie ausleihbar
    Monographie ausleihbar
    Boston [u.a.] : Little, Brown
    Signatur: PIK B 160-08-0080
    Materialart: Monographie ausleihbar
    Seiten: XIX, 396 S.
    ISBN: 0316353000
    Standort: A 18 - Bitte bestellen
    Zweigbibliothek: PIK Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Signatur: PIK N 073-98-0224
    Materialart: Monographie ausleihbar
    Seiten: 322 p.
    ISBN: 1853834076
    Standort: A 18 - Bitte bestellen
    Zweigbibliothek: PIK Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Publikationsdatum: 2013-08-31
    Beschreibung: The auto industry -- one-seventh of the GNP, and the highest expression of the Iron Age -- is about to trigger the biggest transformation in industrial structure since the microchip. Ultralight cars molded from net-shape advanced composites can be several-fold lighter than present steel cars, yet safer, sportier, and more comfortable, durable, and beautiful. Modern hybrid-electric drives boost efficiency approximately 1.3-1.5x in heavy steel cars, but approximately 5-20x in ultralight, very slippery plafforms. Synergistically combined into ultralight-hybrid 'hypercars,' these elements can yield state-of-the-shelf family cars that average 150-300+ mi/gal -- twice that with state-of-the-art technologies -- yet can also be superior in all other respects, probably including cost: carbon-fiber monocoques can actually be cheaper to mass-produce that steel unibodies. Designing cars more like aircraft and less like tanks requires not only an approximately 400-500 kg curb mass and very low air and road drag, but also an aerospace philosophy of engineering integration. Mass, cost, and complexity turn out to compound with heavy hybrids but to decompound with ultralight hybrids, owing partly to radical simplification. Excellent aerodynamics, preferable including advanced techniques for passive boundary-layer control, will be the key to successful design integration. Transforming automaking is a competitive and environmental imperative, could form the nucleus of a green industrial Renaissance, and would enhance national security by, among other things, saving as much oil as OPEC now extracts. However, this transformation faces serious cultural barriers. For example, hypercars will be more like computers with wheels than like cars with chips -- they'll have an order of magnitude more code than today's cars -- but Detroit is not a software culture. Just the transition from stamped and welded steel to integrated and adhesive-joined synthetics is difficult enough. Nonetheless, hypercars are rapidly heading to market in the late 1990s, because approximately 25 current and intending automakers are eager to capture their potentially decisive competitive advantages -- including order-of-magnitude reductions in product cycle time, tooling cost, assembly effort, and parts count. Hypercars will succeed, and may well sweep the market, not because of mandates or subsidies, but because of manufacturers' quest for competitive advantage and customers' desire for better, smarter cars.
    Schlagwort(e): Urban Technology and Transportation
    Materialart: Transportation Beyond 2000: Technologies Needed for Engineering Design; 155-182; NASA-CP-10184-Pt-1
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    facet.materialart.
    Unbekannt
    Barcelona : Galaxia Gutenberg | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publikationsdatum: 2018-11-19
    Schlagwort(e): ddc:600
    Repository-Name: Wuppertal Institut für Klima, Umwelt, Energie
    Sprache: Spanisch
    Materialart: book , doc-type:book
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    facet.materialart.
    Unbekannt
    Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publikationsdatum: 2014-08-15
    Schlagwort(e): ddc:330
    Repository-Name: Wuppertal Institut für Klima, Umwelt, Energie
    Sprache: Deutsch
    Materialart: contributiontoperiodical , doc-type:contributionToPeriodical
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    facet.materialart.
    Unbekannt
    Beijing : Zhong Hua Gong Shang Lian He Chu Ban She | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie
    Publikationsdatum: 2018-11-19
    Schlagwort(e): ddc:600
    Repository-Name: Wuppertal Institut für Klima, Umwelt, Energie
    Sprache: Chinesisch
    Materialart: book , doc-type:book
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Publikationsdatum: 2019-12-26
    Beschreibung: Following mycobacterial entry into macrophages the ESX-1 type VII secretion system promotes phagosomal permeabilization and type I IFN production, key features of tuberculosis pathogenesis. The current model states that the secreted substrate ESAT-6 is required for membrane permeabilization and that a subsequent passive leakage of extracellular bacterial DNA into the host cell cytosol is sensed by the cyclic GMP-AMP synthase (cGAS) and stimulator of IFN genes (STING) pathway to induce type I IFN production. We employed a collection of Mycobacterium marinum ESX-1 transposon mutants in a macrophage infection model and show that permeabilization of the phagosomal membrane does not require ESAT-6 secretion. Moreover, loss of membrane integrity is insufficient to induce type I IFN production. Instead, type I IFN production requires intact ESX-1 function and correlates with release of mitochondrial and nuclear host DNA into the cytosol, indicating that ESX-1 affects host membrane integrity and DNA release via genetically separable mechanisms. These results suggest a revised model for major aspects of ESX-1–mediated host interactions and put focus on elucidating the mechanisms by which ESX-1 permeabilizes host membranes and induces the type I IFN response, questions of importance for our basic understanding of mycobacterial pathogenesis and innate immune sensing.
    Print ISSN: 0027-8424
    Digitale ISSN: 1091-6490
    Thema: Biologie , Medizin , Allgemeine Naturwissenschaft
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1999-09-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lovins, A B -- New York, N.Y. -- Science. 1999 Sep 3;285(5433):1489-91; author reply 1492.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10498532" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Agriculture/*methods ; Crops, Agricultural/*genetics ; Directed Molecular Evolution ; *Food ; *Plants, Genetically Modified ; United States ; United States Department of Agriculture ; United States Environmental Protection Agency ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    facet.materialart.
    Unbekannt
    Institute of Physics (IOP)
    Publikationsdatum: 2018-09-19
    Beschreibung: Most economic theorists assume that energy efficiency—the biggest global provider of energy services—is a limited and dwindling resource whose price- and policy-driven adoption will inevitably deplete its potential and raise its cost. Influenced by that theoretical construct, most traditional analysts and deployers of energy efficiency see and exploit only a modest fraction of the worthwhile efficiency resource, saving less and paying more than they should. Yet empirically, modern energy efficiency is, and shows every sign of durably remaining, an expanding-quantity, declining-cost resource. Its adoption is constrained by major but correctable market failures and increasingly motivated by positive externalities. Most importantly, in both newbuild and retrofit applications, its quantity is severalfold larger and its cost lower than most in the energy and climate communities realize. The efficiency resource far exceeds the sum of savings by individual technologies because artfully...
    Print ISSN: 1748-9318
    Digitale ISSN: 1748-9326
    Thema: Biologie , Energietechnik
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2003-10-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lovins, Amory B -- New York, N.Y. -- Science. 2003 Oct 10;302(5643):226-9; author reply 226-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14558522" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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