Publication Date:
2005-11-16
Description:
Acute Renal Failure (ARF) is a common complication in the early period of myeloablative autologous and allogeneic haematopoietic cell transplantation (HCT). Reported incidence varies from 30% to 80%. This study evaluates retrospectively the incidence of ARF, defined as the doubling of serum creatinine within the first 100 days after HCT, associated risk factors, the need of dialytic therapy as well as mortality of HCT patients who received a myeloablative autologous or allogeneic HCT in our Hospital between January 2003 and December 2004. One-hundred and forty patients (86 men, mean age: 32,9±14,69 years) were studied: 90 patients (53 men, mean age: 33,6±13,73 years) had an allogeneic HCT and 50 (33 men, mean-age: 31,71±16,25 years) an autologous HCT; 82 patients (51 men, mean age: 33,17±14,1 years) received a peripheral blood stem cell (PBSC) transplantation and 58 (35 men, mean age: 32,51±15,61 years) a bone marrow (BM) graft. The incidence of ARF was 21,5% (30/140) (16 men, mean age: 31,53±13,21 years) but did not reach a statistically significant difference between patients who received an allogeneic or autologous HCT (27% vs 12%, p=0.07) or were transplanted with BM graft or PBSC (10% vs 17%, p=ns). Nephrotoxicity (n=20), septic shock (n=16), graft vs host disease (n=6) and veno-occlusive disease (n=3) were the most common etiologies associated with ARF. The incidence of dialysis-dependent ARF was 30% (9/30) and was higher in patients with a BM graft (50% vs 7%, p
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine
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