Electronic Resource
s.l. ; Stafa-Zurich, Switzerland
Journal of biomimetics, biomaterials, and tissue engineering
Vol. 1 (July 2008), p. 69-79
ISSN:
1662-100X
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Biology
,
Technology
Notes:
Palmitic acid was added into drug-loaded poly(L-lactide) (PLLA) to modify the drugrelease profiles of the polymer. The acid was added in different concentrations and gradients acrossthe thickness of the polymer. Drug release was monitored using a UV spectrometer over a period of90 days. Degradation was studied using gel permeation chromatography and differential scanningcalorimetry (DSC) to follow the change in the molecular weight and glass transition temperaturerespectively. Addition of palmitic acid was found to accelerate the degradation of PLLA andresulted in an accelerated release of the drug as expected. Modification of release profiles bydesigning the acid gradient was also attempted. It was found that the total acid concentration is stillthe dominant factor over the gradient design in affecting the degradation and subsequently therelease profiles. Different drug concentrations also played a role in the different release profilesexhibited. Surprisingly the sample with lower drug concentration (2wt%) showed a much higherinitial burst than the 5wt% loaded samples. This was due to the induced nucleation of the polymerby the drug at low concentration resulting in higher crystallinity of the polymer and consequentlyoverall lower solubility of the drug
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/43/transtech_doi~10.4028%252Fwww.scientific.net%252FJBBTE.1.69.pdf
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