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  • 2005-2009  (248)
  • 1
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    Centrosome misorientation reduces stem cell division during ageing (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-10-17
    Description: Asymmetric division of adult stem cells generates one self-renewing stem cell and one differentiating cell, thereby maintaining tissue homeostasis. A decline in stem cell function has been proposed to contribute to tissue ageing, although the underlying mechanism is poorly understood. Here we show that changes in the stem cell orientation with respect to the niche during ageing contribute to the decline in spermatogenesis in the male germ line of Drosophila. Throughout the cell cycle, centrosomes in germline stem cells (GSCs) are oriented within their niche and this ensures asymmetric division. We found that GSCs containing misoriented centrosomes accumulate with age and that these GSCs are arrested or delayed in the cell cycle. The cell cycle arrest is transient, and GSCs appear to re-enter the cell cycle on correction of centrosome orientation. On the basis of these findings, we propose that cell cycle arrest associated with centrosome misorientation functions as a mechanism to ensure asymmetric stem cell division, and that the inability of stem cells to maintain correct orientation during ageing contributes to the decline in spermatogenesis. We also show that some of the misoriented GSCs probably originate from dedifferentiation of spermatogonia.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712891/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712891/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheng, Jun -- Turkel, Nezaket -- Hemati, Nahid -- Fuller, Margaret T -- Hunt, Alan J -- Yamashita, Yukiko M -- P01 DK053074/DK/NIDDK NIH HHS/ -- P01 DK053074-060004/DK/NIDDK NIH HHS/ -- P01 DK53074/DK/NIDDK NIH HHS/ -- R01 GM072006/GM/NIGMS NIH HHS/ -- R01 GM072006-05/GM/NIGMS NIH HHS/ -- R01 GM080501/GM/NIGMS NIH HHS/ -- R01 GM080501-01/GM/NIGMS NIH HHS/ -- R01 GM080501-02/GM/NIGMS NIH HHS/ -- R01 GM086481/GM/NIGMS NIH HHS/ -- R01 GM086481-01/GM/NIGMS NIH HHS/ -- R01GM072006/GM/NIGMS NIH HHS/ -- England -- Nature. 2008 Dec 4;456(7222):599-604. doi: 10.1038/nature07386. Epub 2008 Oct 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biomedical Engineering, Center for Ultrafast Optical Science, University of Michigan, Ann Arbor, Michigan 48109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18923395" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/*physiology ; Animals ; Cell Dedifferentiation ; Cell Division ; Centrosome/*metabolism ; Drosophila melanogaster/*cytology ; Male ; Mitosis ; *Spermatogenesis ; Spermatozoa/*cytology ; Stem Cells/*cytology ; Testis/cytology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Call from China for joint nanotech toxicity-testing effort (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-10-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bi, Shuping -- Zhang, Jing -- Cheng, Jiongjia -- England -- Nature. 2009 Oct 1;461(7264):593. doi: 10.1038/461593a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19794474" target="_blank"〉PubMed〈/a〉
    Keywords: China ; Humans ; Lung Diseases/chemically induced ; Nanoparticles/standards/*toxicity ; Occupational Exposure ; Toxicity Tests/*trends/utilization
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    RNA maps reveal new RNA classes and a possible function for pervasive transcription (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-05-19
    Description: Significant fractions of eukaryotic genomes give rise to RNA, much of which is unannotated and has reduced protein-coding potential. The genomic origins and the associations of human nuclear and cytosolic polyadenylated RNAs longer than 200 nucleotides (nt) and whole-cell RNAs less than 200 nt were investigated in this genome-wide study. Subcellular addresses for nucleotides present in detected RNAs were assigned, and their potential processing into short RNAs was investigated. Taken together, these observations suggest a novel role for some unannotated RNAs as primary transcripts for the production of short RNAs. Three potentially functional classes of RNAs have been identified, two of which are syntenically conserved and correlate with the expression state of protein-coding genes. These data support a highly interleaved organization of the human transcriptome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kapranov, Philipp -- Cheng, Jill -- Dike, Sujit -- Nix, David A -- Duttagupta, Radharani -- Willingham, Aarron T -- Stadler, Peter F -- Hertel, Jana -- Hackermuller, Jorg -- Hofacker, Ivo L -- Bell, Ian -- Cheung, Evelyn -- Drenkow, Jorg -- Dumais, Erica -- Patel, Sandeep -- Helt, Gregg -- Ganesh, Madhavan -- Ghosh, Srinka -- Piccolboni, Antonio -- Sementchenko, Victor -- Tammana, Hari -- Gingeras, Thomas R -- N01-CO-12400/CO/NCI NIH HHS/ -- U01HG003147/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2007 Jun 8;316(5830):1484-8. Epub 2007 May 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Affymetrix Laboratory, Affymetrix, Inc., 3420 Central Expressway, Santa Clara, CA, 95051, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17510325" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Cytosol/metabolism ; Exons ; Gene Expression ; Genome ; *Genome, Human ; HeLa Cells ; Humans ; Mice ; Promoter Regions, Genetic ; RNA/*genetics/metabolism ; RNA Precursors/*genetics/metabolism ; RNA, Messenger/*genetics/*metabolism ; Synteny ; Terminator Regions, Genetic ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Transient simulation of last deglaciation with a new mechanism for Bolling-Allerod warming (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-07-18
    Description: We conducted the first synchronously coupled atmosphere-ocean general circulation model simulation from the Last Glacial Maximum to the Bolling-Allerod (BA) warming. Our model reproduces several major features of the deglacial climate evolution, suggesting a good agreement in climate sensitivity between the model and observations. In particular, our model simulates the abrupt BA warming as a transient response of the Atlantic meridional overturning circulation (AMOC) to a sudden termination of freshwater discharge to the North Atlantic before the BA. In contrast to previous mechanisms that invoke AMOC multiple equilibrium and Southern Hemisphere climate forcing, we propose that the BA transition is caused by the superposition of climatic responses to the transient CO(2) forcing, the AMOC recovery from Heinrich Event 1, and an AMOC overshoot.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Z -- Otto-Bliesner, B L -- He, F -- Brady, E C -- Tomas, R -- Clark, P U -- Carlson, A E -- Lynch-Stieglitz, J -- Curry, W -- Brook, E -- Erickson, D -- Jacob, R -- Kutzbach, J -- Cheng, J -- New York, N.Y. -- Science. 2009 Jul 17;325(5938):310-4. doi: 10.1126/science.1171041.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Key Laboratory of Meteorological Disaster, Nanjing University of Information Science and Technology, Nanjing, 210044, China. zliu3@wisc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19608916" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-03-26
    Description: Sites of transcription of polyadenylated and nonpolyadenylated RNAs for 10 human chromosomes were mapped at 5-base pair resolution in eight cell lines. Unannotated, nonpolyadenylated transcripts comprise the major proportion of the transcriptional output of the human genome. Of all transcribed sequences, 19.4, 43.7, and 36.9% were observed to be polyadenylated, nonpolyadenylated, and bimorphic, respectively. Half of all transcribed sequences are found only in the nucleus and for the most part are unannotated. Overall, the transcribed portions of the human genome are predominantly composed of interlaced networks of both poly A+ and poly A- annotated transcripts and unannotated transcripts of unknown function. This organization has important implications for interpreting genotype-phenotype associations, regulation of gene expression, and the definition of a gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheng, Jill -- Kapranov, Philipp -- Drenkow, Jorg -- Dike, Sujit -- Brubaker, Shane -- Patel, Sandeep -- Long, Jeffrey -- Stern, David -- Tammana, Hari -- Helt, Gregg -- Sementchenko, Victor -- Piccolboni, Antonio -- Bekiranov, Stefan -- Bailey, Dione K -- Ganesh, Madhavan -- Ghosh, Srinka -- Bell, Ian -- Gerhard, Daniela S -- Gingeras, Thomas R -- New York, N.Y. -- Science. 2005 May 20;308(5725):1149-54. Epub 2005 Mar 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Affymetrix Inc., Santa Clara, CA 95051, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790807" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Chromosomes, Human/*genetics ; Chromosomes, Human, Pair 13/genetics ; Chromosomes, Human, Pair 14/genetics ; Chromosomes, Human, Pair 19/genetics ; Chromosomes, Human, Pair 20/genetics ; Chromosomes, Human, Pair 21/genetics ; Chromosomes, Human, Pair 22/genetics ; Chromosomes, Human, Pair 6/genetics ; Chromosomes, Human, Pair 7/genetics ; Chromosomes, Human, X/genetics ; Chromosomes, Human, Y/genetics ; Computational Biology ; Cytosol/metabolism ; DNA, Complementary ; DNA, Intergenic ; Exons ; Female ; *Genome, Human ; Humans ; Introns ; Male ; Molecular Sequence Data ; Nucleic Acid Amplification Techniques ; Oligonucleotide Array Sequence Analysis ; Physical Chromosome Mapping ; RNA Splicing ; RNA, Messenger/*analysis ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
    Electronic Resource
    Electronic Resource
    Preparation and Characterization of Cerium Hydrate Fiber (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 336-338 (Apr. 2007), p. 2182-2185 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Cerium hydrate fiber (CHF), which showed an aspect ratio greater than 100, wassynthesized by a novel method, which used the mixing of cerium nitrate (Ce(NO3)3), sodium hydrate(NaOH) and citric acid (C6H8O7) synthesized at a relative low temperature and ambient pressure. Theprecipitates were characterized by XRD, SEM and TEM. The results showed that in addition to fibers,two morphologies could be obtained depending on the synthesizing conditions. Aging time andformulation were two key factors for the control of the aspect ratio of the precipitates. By a heatingtreatment at 600oC for 2 h, the homogenous and well-crystallized cerium dioxide (CeO2) fiber can befabricated. The effects of synthesis parameters, such as the concentration of the starting solution,aging period, and pH value were reported and discussed
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.336-338.2182.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Homogeneity of Aqueous Al〈sub〉2〈/sub〉O〈sub〉3〈/sub〉/3Y-TZP Feedstock by Plastic Kneading (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 336-338 (Apr. 2007), p. 1127-1129 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The effects of different kneading sequences, chemical additives, and solid loadings to thehomogeneity and rheological behavior of the Al2O3/3Y-TZP (ZTA) feedstock were investigated. Theproperties of the feedstock were analyzed by the torque rheometry, transmission optical microscopy (OM)and scanning and transmission electron microscopy (SEM & TEM). The optimal kneading process wasdetermined when good homogeneity was reached. The concepts of critical solid loading and thehomogeneity of two-oxide systems, and the power consumption to reach best microstructure will beintroduced and quantitatively analyzed
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.336-338.1127.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Development of Micro-Solid Oxide Fuel Cells (Micro-SOFCs) (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 51 (June 2008), p. 111-115 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Solid Oxide Fuel Cell (SOFC) has several non-replaceable advantages over the others, e.g.the issues of high volumetric power density and low cost. Those advantages have been appreciated inrecent developments, and implemented in several micro-SOFC devices conducted by severalinternational projects. ONEBAT System by ETH (with 4 other groups) in Switzerland, micro-tubularSOFC by AIST in Japan, micro-honeycomb fuel cell (FC) by Professor Ishihara at Kyushu Universitywill be reviewed in this report. Some micro-devices have been built on Si-chip, or in associated withthe accessory parts, such as fuel reformer, electric power collector, or micro-turbine. Those havedemonstrated important technology breakthrough and also shown the potential for commercialapplications. This report will also discuss two important issues, including gas transport limitation insmall gaps and glass sealing for the practical applications of Micro-SOFCs
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/41/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.51.111.pdf
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  • 9
    Electronic Resource
    Electronic Resource
    High-Quality Single-Walled Carbon Nanotubes Synthesized by Floating Catalyst Chemical Vapor Depostion (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 47-50 (June 2008), p. 746-749 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: High-quality single-walled carbon nanotubes (SWNTs) are a key aspect in the emergingfield nanotechnology. Although many approaches have been developed, the research on thesynthesis of SWNTs is still needed. In this study, we report the synthesis of high-quality SWNTs byfloating catalyst chemical vapor deposition, which employs ferrocene as the catalyst precursors. Weobtained massive deposits at low temperature region. The deposits were characterized by scanningelectron microscopy, transmission electron microscopy, and visual laser Raman spectroscopy. TheRaman spectrum obtained from raw deposits shows clear radial breathing mode at the range from180cm-1 to 300cm-1 and high-intensity graphite mode at 1577.7cm-1 with a shoulder at 1550.5cm-1,and almost no detectable peak around at 1545cm-1, which is induced by defects, is observed. Theseresults indicate that the deposits are high-quality SWNTs
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/41/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.47-50.746.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    Investigation of YSZ Thin Films on Silicon Wafer and NiO/YSZ Deposited by Ion Beam Sputtering Deposition (IBSD) (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 336-338 (Apr. 2007), p. 1788-1790 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Ion-beam sputtering deposition is a physical deposited method which uses accelerated ionbeamto sputter oxide or metal targets, and deposits atoms on substrate. Thin films of yttrium-stabilizedzirconia (YSZ) were deposited on Si (100) wafer and NiO/YSZ plate. Scanning electron microscopy andtransmission electron microscopy with EDS were employed to study the microstructural and chemicallystoichiometric results of the films and the crystal growth process by various heat treatments. X-raydiffraction was also used to analysis crystalline phase of the YSZ films. The influence of different targets,substrates deposited efficiency and the properties of the film will be presented and discussed
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.336-338.1788.pdf
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