Publication Date:
2008-09-20
Description:
White adipose (fat) tissues regulate metabolism, reproduction, and life span. Adipocytes form throughout life, with the most marked expansion of the lineage occurring during the postnatal period. Adipocytes develop in coordination with the vasculature, but the identity and location of white adipocyte progenitor cells in vivo are unknown. We used genetically marked mice to isolate proliferating and renewing adipogenic progenitors. We found that most adipocytes descend from a pool of these proliferating progenitors that are already committed, either prenatally or early in postnatal life. These progenitors reside in the mural cell compartment of the adipose vasculature, but not in the vasculature of other tissues. Thus, the adipose vasculature appears to function as a progenitor niche and may provide signals for adipocyte development.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597101/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597101/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tang, Wei -- Zeve, Daniel -- Suh, Jae Myoung -- Bosnakovski, Darko -- Kyba, Michael -- Hammer, Robert E -- Tallquist, Michelle D -- Graff, Jonathan M -- 1R01DK064261/DK/NIDDK NIH HHS/ -- 1R01DK066556/DK/NIDDK NIH HHS/ -- R01 DK064261/DK/NIDDK NIH HHS/ -- R01 DK064261-01/DK/NIDDK NIH HHS/ -- R01 DK064261-02/DK/NIDDK NIH HHS/ -- R01 DK064261-03/DK/NIDDK NIH HHS/ -- R01 DK064261-04/DK/NIDDK NIH HHS/ -- R01 DK064261-05/DK/NIDDK NIH HHS/ -- R01 DK066556/DK/NIDDK NIH HHS/ -- R01 DK066556-01/DK/NIDDK NIH HHS/ -- R01 DK066556-02/DK/NIDDK NIH HHS/ -- R01 DK066556-03/DK/NIDDK NIH HHS/ -- R01 DK066556-04/DK/NIDDK NIH HHS/ -- R01 DK066556-05/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2008 Oct 24;322(5901):583-6. doi: 10.1126/science.1156232. Epub 2008 Sep 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18801968" target="_blank"〉PubMed〈/a〉
Keywords:
Adipocytes, White/*cytology/metabolism
;
Adipogenesis
;
Adipose Tissue/*blood supply/cytology
;
Animals
;
Antigens, CD/metabolism
;
Blood Vessels/*cytology
;
Cell Lineage
;
Cell Proliferation
;
Cell Separation
;
Cells, Cultured
;
Doxycycline/pharmacology
;
Gene Expression Profiling
;
Mice
;
Mice, Transgenic
;
Multipotent Stem Cells/*cytology/metabolism
;
PPAR gamma/genetics/metabolism
;
Stromal Cells/*cytology/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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