Publication Date:
2007-03-03
Description:
Stimulant addiction is often linked to excessive risk taking, sensation seeking, and impulsivity, but in ways that are poorly understood. We report here that a form of impulsivity in rats predicts high rates of intravenous cocaine self-administration and is associated with changes in dopamine (DA) function before drug exposure. Using positron emission tomography, we demonstrated that D2/3 receptor availability is significantly reduced in the nucleus accumbens of impulsive rats that were never exposed to cocaine and that such effects are independent of DA release. These data demonstrate that trait impulsivity predicts cocaine reinforcement and that D2 receptor dysfunction in abstinent cocaine addicts may, in part, be determined by premorbid influences.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892797/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892797/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dalley, Jeffrey W -- Fryer, Tim D -- Brichard, Laurent -- Robinson, Emma S J -- Theobald, David E H -- Laane, Kristjan -- Pena, Yolanda -- Murphy, Emily R -- Shah, Yasmene -- Probst, Katrin -- Abakumova, Irina -- Aigbirhio, Franklin I -- Richards, Hugh K -- Hong, Young -- Baron, Jean-Claude -- Everitt, Barry J -- Robbins, Trevor W -- 076244/Wellcome Trust/United Kingdom -- G0001354/Medical Research Council/United Kingdom -- G0401068/Medical Research Council/United Kingdom -- G0600196/Medical Research Council/United Kingdom -- G0600986/Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2007 Mar 2;315(5816):1267-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK. jwd20@cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17332411" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Basal Ganglia/metabolism/radionuclide imaging
;
Benzamides/metabolism
;
Cocaine/*administration & dosage
;
*Cocaine-Related Disorders/metabolism/psychology
;
Corpus Striatum/metabolism/radionuclide imaging
;
Dopamine/metabolism
;
Dopamine Antagonists/metabolism/pharmacology
;
*Impulsive Behavior
;
Male
;
Nucleus Accumbens/*metabolism/radionuclide imaging
;
Positron-Emission Tomography
;
Pyrrolidines/metabolism
;
Rats
;
Reaction Time
;
Receptors, Dopamine D2/*metabolism
;
Receptors, Dopamine D3/*metabolism
;
*Reinforcement (Psychology)
;
Self Administration
;
Synaptic Transmission
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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