Publication Date:
2014-09-04
Description:
Article PIKfyve is a lipid kinase essential for regulation of membrane homeostasis and vesicle trafficking along the endosomal-lysosomal pathway. Here the authors show that mice lacking PIKfyve exclusively in their platelets exhibit a systemic disorder characterized by multi-organ inflammation and thrombosis due to aberrant platelet lysosome function. Nature Communications doi: 10.1038/ncomms5691 Authors: Sang H. Min, Aae Suzuki, Timothy J. Stalker, Liang Zhao, Yuhuan Wang, Chris McKennan, Matthew J. Riese, Jessica F. Guzman, Suhong Zhang, Lurong Lian, Rohan Joshi, Ronghua Meng, Steven H. Seeholzer, John K. Choi, Gary Koretzky, Michael S. Marks, Charles S. Abrams
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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