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  • 1
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    SIK1 localizes with nephrin in glomerular podocytes and its polymorphism predicts kidney injury (2014)
    Oxford University Press
    Details
    Publication Date: 2014-07-19
    Description: Mutant α-adducin and endogenous ouabain levels exert a causal role in hypertension by affecting renal Na–K ATPase. In addition, mutant β-adducin is involved in glomerular damage through nephrin down-regulation. Recently, the salt-inducible kinase 1 (SIK1) has been shown to exert a permissive role on mutant α-adducin effects on renal Na–K ATPase activity involved in blood pressure (BP) regulation and a SIK1 rs3746951 polymorphism has been associated with changes in vascular Na–K ATPase activity and BP. Here, we addressed the role of SIK1 on nephrin and glomerular functional modifications induced by mutant β-adducin and ouabain, by using congenic substrains of the Milan rats expressing either mutant α- or β-adducin, alone or in combination, ouabain hypertensive rats (OHR) and hypertensive patients. SIK1 co-localized and co-immunoprecipitated with nephrin from glomerular podocytes and associated with caveolar nephrin signaling. In cultured podocytes, nephrin-gene silencing decreased SIK1 expression. In mutant β-adducin congenic rats and in OHR, the podocyte damage was associated with decreased nephrin and SIK1 expression. Conversely, when the effects of β-adducin on podocytes were blocked by the presence of mutant α-adducin, nephrin and SIK1 expressions were restored. Ouabain effects were also reproduced in cultured podocytes. In hypertensive patients, nephrinuria, but not albuminuria, was higher in carriers of mutant SIK1 rs3746951 than in wild-type, implying a more direct effect of SIK1 on glomerular damage. These results demonstrate that, through nephrin, SIK1 is involved in the glomerular effects of mutant adducin and ouabain and a direct effect of SIK1 is also likely to occur in humans.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 2
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    RETRACTED: SIK1 localizes with nephrin in glomerular podocytes and its polymorphism predicts kidney injury (2014)
    Oxford University Press
    Details
    Publication Date: 2014-04-03
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 3
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    A Crustal Model for the Eastern Alps Region and a New Moho Map in Southeastern Europe (2012)
    Springer Verlag
    Details
    Publication Date: 2017-04-04
    Description: In the last two decades, south-central Europe and the Eastern Alps have been widely explored by many seismic refrac- tion experiments (e.g., CELEBRATION 2000, ALP 2002, SUDETES 2003). Although quite detailed images are available along linear profiles, a comprehensive, three-dimensional crustal model of the region is still missing. This limitation makes this region a weak spot in continental-wide comprehensive represen- tations of crustal structure. To improve on this situation, we select and collect 37 published active-source seismic lines in this region. After geo-referencing each line, we sample them along vertical profiles—every 50 km or less along the line—and derive P-wave velocities in a stack of homogeneous layers (separated by discon- tinuities: depth of crystalline basement, top of lower crust, and Moho). We finally merge the information using geostatistical methods, and infer S-wave velocity and density using empirical scaling relations. We present here the resulting crustal model for a region encompassing the Eastern Alps, Dinarides, Pannonian basin, Western Carpathians and Bohemian Massif, covering the region within 45º-51ºN and 11º-22ºE with a resolution of 0.2ºx0.2º. We are also able to extend and update the map of Moho depth in a wider region within 35^-51^N and 12^-45^E; gathering Moho values from the collected seismic lines, other published dataset and using the European plate reference EPcrust as a background. All the digitized profiles and the resulting model are available online.
    Description: Published
    Description: 1575-1588
    Description: 3.3. Geodinamica e struttura dell'interno della Terra
    Description: JCR Journal
    Description: restricted
    Keywords: Crustal model ; crust ; Moho depth ; Europe ; Eastern Alps ; kriging ; 04. Solid Earth::04.06. Seismology::04.06.07. Tomography and anisotropy
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 4
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    EPcrust : A reference crustal model for the European plate (2011)
    Blackwell Publishing Ltd
    Details
    Publication Date: 2017-04-04
    Description: We present a new crustal model for the European plate, derived from collection and critical integration of information selected from the literature. The model covers the whole European plate from North Africa to the North Pole (20N - 90N) and from the Mid-Atlantic Ridge to the Urals (40W - 70E). The chosen parameterization represents the crust in three layers (sediments, upper crust and lower crust), and describes the 3D geometry of the interfaces and seismologically-relevant parameters — isotropic P- and S-wave velocity, plus density — with a resolution of 0.5 × 0.5 degrees on a geographical latitude-longitude grid. We selected global and local models, derived from geological assumptions, active seismic experiments, surface-wave studies, noise correlation, receiver functions. Model EPcrust presents significant advantages with respect to previous models: it covers the whole European plate; it is a complete and internally-consistent model (with all the parameters provided, also for the sedimentary layer); it is reproducible; it is easy to update in the future by adding new contributions; and it is available in a convenient digital format. EPcrust could be used to account for crustal structure in seismic wave propagation modeling at continental scale or to compute linearized crustal corrections in continental-scale seismic tomography, gravity studies, dynamic topography and other applications that require a reliable crustal structure. Because of its resolution, our model is not suited for local-scale studies, such as the computation of earthquake scenarios, where more detailed knowledge of the structure is required. We plan to update the model as new data will become available, and possibly improve its resolution for selected areas in the future.
    Description: Published
    Description: 352-364
    Description: 3.3. Geodinamica e struttura dell'interno della Terra
    Description: JCR Journal
    Description: reserved
    Keywords: Europe ; crust ; crustal properties ; Moho ; 04. Solid Earth::04.01. Earth Interior::04.01.99. General or miscellaneous ; 04. Solid Earth::04.01. Earth Interior::04.01.01. Composition and state
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 5
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    Upper mantle structure below the European continent: Constraints from surface-wave tomography and GRACE satellite gravity data (2012)
    American Geophysical Union
    Details
    Publication Date: 2017-04-04
    Description: We here exploit fundamental mode Rayleigh and Love seismic wave information and the high resolution satellite global gravity model GGM02C to obtain a 1° × 1° 3-D image of: (a) upper-mantle isotropic shear-wave speeds; (b) densities; and (c) density-vS coupling below the European plate (20°N–90°N) (40°W–70°E). The 3-D image of the density-vS coupling provides unprecedented detail of information on the compositional and thermal contributions to density structures. The accurate and high-resolution crustal model allows us to compute a reliable residual topography to understand the dynamic implications of our models. The correlation between residual topography and mantle residual gravity anomalies defines three large-scale regions where upper mantle dynamics produce surface expression: the East European Craton; the eastern side of the Arabian Plate; and the Mediterranean Basin. The effects of mantle convection are also clearly visible at: (1) the Eastern Sirt Embayment; (2) the West African Craton northern margins; (3) the volcanically active region of the Canarian Archipelago; (4) the northern edge of the Central European Volcanic Province; and (5) the Northeastern part of the Atlantic Ocean, between Greenland and Iceland. Strong connections are observed among areas of weak radial anisotropy and areas where the mantle dynamics show surface expression. Although both thermal and additional dependencies have been incorporated into the density model, convective down-welling in the mantle below the East European Craton is required to explain the strong correlation between the estimated negative mantle residual anomalies and the negative residual topography.
    Description: DATEC MERG-CT-2007-046522 and NERIES INFRAST-2.1-026130
    Description: Published
    Description: B09401
    Description: 3.3. Geodinamica e struttura dell'interno della Terra
    Description: JCR Journal
    Description: restricted
    Keywords: Europe ; GRACE ; density-velocity scaling relationship ; dynamic topography ; surface waves ; upper mantle density ; 04. Solid Earth::04.01. Earth Interior::04.01.01. Composition and state ; 04. Solid Earth::04.03. Geodesy::04.03.03. Gravity and isostasy ; 04. Solid Earth::04.06. Seismology::04.06.07. Tomography and anisotropy ; 04. Solid Earth::04.07. Tectonophysics::04.07.02. Geodynamics ; 05. General::05.01. Computational geophysics::05.01.03. Inverse methods
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 6
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    Upper mantle structure below the European continent: Constraints from surface-wave tomography and GRACE satellite gravity data (2012)
    In:  Journal of Geophysical Research
    Details
    Publication Date: 2020-02-12
    Description: We here exploit fundamental mode Rayleigh and Love seismic wave information and the high resolution satellite global gravity model GGM02C to obtain a 1° × 1° 3-D image of: (a) upper-mantle isotropic shear-wave speeds; (b) densities; and (c) density-vScoupling below the European plate (20°N–90°N) (40°W–70°E). The 3-D image of the density-vScoupling provides unprecedented detail of information on the compositional and thermal contributions to density structures. The accurate and high-resolution crustal model allows us to compute a reliable residual topography to understand the dynamic implications of our models. The correlation between residual topography and mantle residual gravity anomalies defines three large-scale regions where upper mantle dynamics produce surface expression: the East European Craton; the eastern side of the Arabian Plate; and the Mediterranean Basin. The effects of mantle convection are also clearly visible at: (1) the Eastern Sirt Embayment; (2) the West African Craton northern margins; (3) the volcanically active region of the Canarian Archipelago; (4) the northern edge of the Central European Volcanic Province; and (5) the Northeastern part of the Atlantic Ocean, between Greenland and Iceland. Strong connections are observed among areas of weak radial anisotropy and areas where the mantle dynamics show surface expression. Although both thermal and additional dependencies have been incorporated into the density model, convective down-welling in the mantle below the East European Craton is required to explain the strong correlation between the estimated negative mantle residual anomalies and the negative residual topography.
    Language: English
    Type: info:eu-repo/semantics/article
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