Publication Date:
2011-03-15
Description:
From the aerial parts of Senecio dianthus , four new eremophilenolides ( 1 – 4 , resp.) and one new eremophilenolide alkaloid ( 5 ), of the relatively uncommon eremophilenoid-type sesquiterpenoid lactones, were isolated together with three known sesquiterpenoid lactones, 10 β -hydroxyeremophil-7(11)-en-12,8 α -olide ( 6 ), 8 β ,10 β -dihydroxyeremophil-7(11)-en-12,8 α -olide ( 7 ), and 10 α -hydroxy-1-oxoeremophila-7(11),8(9)-dien-12,8-olide ( 8 ). On the basis of IR, MS, and NMR data, particularly 2D-NMR analyses, the structures of the new compounds were established as: 2 β -(angeloyloxy)-10 β -hydroxyeremophil-7(11)-en-12,8 α -olide ( 1 ), 6 β -(angeloyloxy)-10 β -hydroxyeremophil-7(11)-en-12,8 α -olide ( 2 ), 2 β -(angeloyloxy)-8 β ,10 β -dihydroxyeremophil-7(11)-en-12,8 α -olide ( 3 ), 2 β -(angeloyloxy)-8 α -hydroxyeremophila-7(11),9(10)-dien-12,8 β -olide ( 4 ), and 8 β -amino-10 β -hydroxyeremophil-7(11)-en-12,8 α -olide ( 5 ). In addition, the relative configuration of 1 was corroborated by X-ray diffraction analysis.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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