Publication Date:
2014-03-13
Description:
Article Hepatic insulin resistance is a hallmark of diabetes, but its aetiology is incompletely understood. Here, Uchimura and colleagues show that the serine protease prostasin cleaves Toll-like receptor 4 (TLR4) and regulates hepatic insulin sensitivity by modulating TLR4-mediated signalling. Nature Communications doi: 10.1038/ncomms4428 Authors: Kohei Uchimura, Manabu Hayata, Teruhiko Mizumoto, Yoshikazu Miyasato, Yutaka Kakizoe, Jun Morinaga, Tomoaki Onoue, Rika Yamazoe, Miki Ueda, Masataka Adachi, Taku Miyoshi, Naoki Shiraishi, Wataru Ogawa, Kazuki Fukuda, Tatsuya Kondo, Takeshi Matsumura, Eiichi Araki, Kimio Tomita, Kenichiro Kitamura
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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