ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Oxford University Press  (3)
  • 2010-2014  (3)
Collection
Years
Year
  • 1
    Publication Date: 2012-08-23
    Description: Detailed analyses of the chromatin around the BIM promoter has revealed that latent Epstein–Barr virus (EBV) triggers the recruitment of polycomb repressive complex 2 (PRC2) core subunits and the trimethylation of histone H3 lysine 27 (H3K27me3) at this locus. The recruitment is absolutely dependent on nuclear proteins EBNA3A and EBNA3C; what is more, epitope-tagged EBNA3C could be shown bound near the transcription start site (TSS). EBV induces no consistent changes in the steady-state expression of PRC2 components, but lentivirus delivery of shRNAs against PRC2 and PRC1 subunits disrupted EBV repression of BIM . The activation mark H3K4me3 is largely unaltered at this locus irrespective of H3K27me3 status, suggesting the establishment of a ‘bivalent’ chromatin domain. Consistent with the ‘poised’ nature of these domains, RNA polymerase II (Pol II) occupancy was not altered by EBV at the BIM TSS, but analysis of phospho-serine 5 on Pol II indicated that EBNA3A and EBNA3C together inhibit initiation of BIM transcripts. B cell lines carrying EBV encoding a conditional EBNA3C-oestrogen receptor-fusion revealed that this epigenetic repression of BIM was reversible, but took more than 3 weeks from when EBNA3C was inactivated.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    Publication Date: 2014-06-20
    Description: We investigate the effects of galaxy formation on the baryonic acoustic oscillation (BAO) peak by applying semi-analytic modelling techniques to the Millennium-XXL, a 3 10 11 particle N -body simulation of similar volume to the future Euclid survey. Our approach explicitly incorporates the effects of tidal fields and stochasticity on halo formation, as well as the presence of velocity bias, spatially correlated merger histories, and the connection of all these with the observable and physical properties of galaxies. We measure significant deviations in the shape of the BAO peak from the expectations of a linear bias model built on top of the non-linear dark matter distribution. We find that the galaxy correlation function shows an excess close to the maximum of the BAO peak ( r ~ 110 h –1 Mpc) and a deficit at r ~ 90 h –1 Mpc. Depending on the redshift, selection criteria and number density of the galaxy samples, these biased distortions can be up to 5 per cent in amplitude. They are, however, largely absorbed by marginalization over nuisance parameters in current analytical modelling of the BAO peak in configuration space, in particular into the parameter that controls the broadening due to non-linear evolution. As a result, the galaxy formation effects detected here are unlikely to bias the high-precision measurements planned by the upcoming generation of wide-field galaxy surveys.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2014-08-01
    Description: We develop and test a new statistical method to measure the kinematic Sunyaev-Zel'dovich (kSZ) effect. A sample of independently detected clusters is combined with the cosmic flow field predicted from a galaxy redshift survey in order to derive a matched filter that optimally weights the kSZ signal for the sample as a whole given the noise involved in the problem. We apply this formalism to realistic mock microwave skies based on cosmological N -body simulations, and demonstrate its robustness and performance. In particular, we carefully assess the various sources of uncertainty, cosmic microwave background primary fluctuations, instrumental noise, uncertainties in the determination of the velocity field, and effects introduced by miscentring of clusters and by uncertainties of the mass-observable relation (normalization and scatter). We show that available data ( Planck maps and the MaxBCG catalogue) should deliver a 7.7 detection of the kSZ. A similar cluster catalogue with broader sky coverage should increase the detection significance to ~13. We point out that such measurements could be binned in order to study the properties of the cosmic gas and velocity fields, or combined into a single measurement to constrain cosmological parameters or deviations of the law of gravity from General Relativity.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...