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  • American Association for the Advancement of Science (AAAS)
  • 2010-2014  (7)
  • 1
    Publication Date: 2010-01-09
    Description: Large-scale biodiversity gradients among environments and habitats are usually attributed to a complex array of ecological and evolutionary factors. We tested the evolutionary component of such gradients by compiling the environments of the geologically oldest occurrences of marine genera and using sampling standardization to assess if originations tended to be clustered in particular environments. Shallow, tropical environments and carbonate substrates all tend to have harbored high origination rates. Diversity within these environments tended to be preferentially generated in reefs, probably because of their habitat complexity. Reefs were also prolific at exporting diversity to other environments, which might be a consequence of low-diversity habitats being more susceptible to invasions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kiessling, Wolfgang -- Simpson, Carl -- Foote, Michael -- New York, N.Y. -- Science. 2010 Jan 8;327(5962):196-8. doi: 10.1126/science.1182241.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Museum fur Naturkunde, Leibniz Institute for Research on Evolution and Biodiversity at the Humboldt University Berlin, 10115 Berlin, Germany. wolfgang.kiessling@mfn-berlin.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20056888" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Anthozoa ; *Biodiversity ; *Biological Evolution ; Calcium Carbonate ; *Ecosystem ; Environment ; Fishes ; *Fossils ; Geography ; *Invertebrates/classification
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2011-02-26
    Description: Certain fish and amphibians retain a robust capacity for cardiac regeneration throughout life, but the same is not true of the adult mammalian heart. Whether the capacity for cardiac regeneration is absent in mammals or whether it exists and is switched off early after birth has been unclear. We found that the hearts of 1-day-old neonatal mice can regenerate after partial surgical resection, but this capacity is lost by 7 days of age. This regenerative response in 1-day-old mice was characterized by cardiomyocyte proliferation with minimal hypertrophy or fibrosis, thereby distinguishing it from repair processes. Genetic fate mapping indicated that the majority of cardiomyocytes within the regenerated tissue originated from preexisting cardiomyocytes. Echocardiography performed 2 months after surgery revealed that the regenerated ventricular apex had normal systolic function. Thus, for a brief period after birth, the mammalian heart appears to have the capacity to regenerate.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099478/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099478/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Porrello, Enzo R -- Mahmoud, Ahmed I -- Simpson, Emma -- Hill, Joseph A -- Richardson, James A -- Olson, Eric N -- Sadek, Hesham A -- HL100401-01/HL/NHLBI NIH HHS/ -- R01 HL077439/HL/NHLBI NIH HHS/ -- R01 HL077439-06/HL/NHLBI NIH HHS/ -- R01 HL077439-06W1/HL/NHLBI NIH HHS/ -- R01 HL077439-07/HL/NHLBI NIH HHS/ -- R01 HL077439-08/HL/NHLBI NIH HHS/ -- R01 HL093039/HL/NHLBI NIH HHS/ -- R01 HL093039-01A1/HL/NHLBI NIH HHS/ -- R01 HL093039-01A1W1/HL/NHLBI NIH HHS/ -- R01 HL093039-02/HL/NHLBI NIH HHS/ -- R01 HL093039-03/HL/NHLBI NIH HHS/ -- R01 HL115275/HL/NHLBI NIH HHS/ -- R37 HL053351/HL/NHLBI NIH HHS/ -- R37 HL053351-12/HL/NHLBI NIH HHS/ -- R37 HL053351-13/HL/NHLBI NIH HHS/ -- R37 HL053351-14/HL/NHLBI NIH HHS/ -- R37 HL053351-15/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2011 Feb 25;331(6020):1078-80. doi: 10.1126/science.1200708.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21350179" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Animals, Newborn ; Cardiomegaly ; Cell Lineage ; Cell Proliferation ; Echocardiography ; Fibrosis ; Heart/*physiology ; Heart Ventricles/surgery ; Mice ; Myocardial Contraction ; Myocardium/pathology ; Myocytes, Cardiac/*physiology ; *Regeneration ; Sarcomeres/ultrastructure ; Stroke Volume
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2013-06-08
    Description: Although cortico-striato-thalamo-cortical (CSTC) circuit dysregulation is correlated with obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used optogenetics in mice to simulate CSTC hyperactivation observed in OCD patients. Whereas acute orbitofrontal cortex (OFC)-ventromedial striatum (VMS) stimulation did not produce repetitive behaviors, repeated hyperactivation over multiple days generated a progressive increase in grooming, a mouse behavior related to OCD. Increased grooming persisted for 2 weeks after stimulation cessation. The grooming increase was temporally coupled with a progressive increase in light-evoked firing of postsynaptic VMS cells. Both increased grooming and evoked firing were reversed by chronic fluoxetine, a first-line OCD treatment. Brief but repeated episodes of abnormal circuit activity may thus set the stage for the development of persistent psychopathology.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954809/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954809/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ahmari, Susanne E -- Spellman, Timothy -- Douglass, Neria L -- Kheirbek, Mazen A -- Simpson, H Blair -- Deisseroth, Karl -- Gordon, Joshua A -- Hen, Rene -- K01 MH099371/MH/NIMH NIH HHS/ -- K01MH099371/MH/NIMH NIH HHS/ -- K08 MH087718/MH/NIMH NIH HHS/ -- K08MH087718/MH/NIMH NIH HHS/ -- K24 MH091555/MH/NIMH NIH HHS/ -- R01 MH096274/MH/NIMH NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Jun 7;340(6137):1234-9. doi: 10.1126/science.1234733.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. sea2103@columbia.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23744948" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviridae ; Animals ; Artificial Gene Fusion ; Bacterial Proteins/genetics ; Behavior, Animal ; Corpus Striatum/drug effects/*physiopathology ; Electric Stimulation ; Fluoxetine/pharmacology ; Frontal Lobe/drug effects/*physiopathology ; Luminescent Proteins/genetics ; Male ; Mice ; Obsessive-Compulsive Disorder/*physiopathology/*psychology ; Optogenetics ; Rhodopsin/biosynthesis/genetics ; Serotonin Uptake Inhibitors/pharmacology ; Thalamus/drug effects/*physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2010-11-06
    Description: Gravitational lensing is a powerful astrophysical and cosmological probe and is particularly valuable at submillimeter wavelengths for the study of the statistical and individual properties of dusty star-forming galaxies. However, the identification of gravitational lenses is often time-intensive, involving the sifting of large volumes of imaging or spectroscopic data to find few candidates. We used early data from the Herschel Astrophysical Terahertz Large Area Survey to demonstrate that wide-area submillimeter surveys can simply and easily detect strong gravitational lensing events, with close to 100% efficiency.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Negrello, Mattia -- Hopwood, R -- De Zotti, G -- Cooray, A -- Verma, A -- Bock, J -- Frayer, D T -- Gurwell, M A -- Omont, A -- Neri, R -- Dannerbauer, H -- Leeuw, L L -- Barton, E -- Cooke, J -- Kim, S -- da Cunha, E -- Rodighiero, G -- Cox, P -- Bonfield, D G -- Jarvis, M J -- Serjeant, S -- Ivison, R J -- Dye, S -- Aretxaga, I -- Hughes, D H -- Ibar, E -- Bertoldi, F -- Valtchanov, I -- Eales, S -- Dunne, L -- Driver, S P -- Auld, R -- Buttiglione, S -- Cava, A -- Grady, C A -- Clements, D L -- Dariush, A -- Fritz, J -- Hill, D -- Hornbeck, J B -- Kelvin, L -- Lagache, G -- Lopez-Caniego, M -- Gonzalez-Nuevo, J -- Maddox, S -- Pascale, E -- Pohlen, M -- Rigby, E E -- Robotham, A -- Simpson, C -- Smith, D J B -- Temi, P -- Thompson, M A -- Woodgate, B E -- York, D G -- Aguirre, J E -- Beelen, A -- Blain, A -- Baker, A J -- Birkinshaw, M -- Blundell, R -- Bradford, C M -- Burgarella, D -- Danese, L -- Dunlop, J S -- Fleuren, S -- Glenn, J -- Harris, A I -- Kamenetzky, J -- Lupu, R E -- Maddalena, R J -- Madore, B F -- Maloney, P R -- Matsuhara, H -- Michaowski, M J -- Murphy, E J -- Naylor, B J -- Nguyen, H -- Popescu, C -- Rawlings, S -- Rigopoulou, D -- Scott, D -- Scott, K S -- Seibert, M -- Smail, I -- Tuffs, R J -- Vieira, J D -- van der Werf, P P -- Zmuidzinas, J -- New York, N.Y. -- Science. 2010 Nov 5;330(6005):800-4. doi: 10.1126/science.1193420.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics and Astronomy, The Open University, Walton Hall, Milton Keynes, MK7 6AA, UK. m.negrello@open.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21051633" target="_blank"〉PubMed〈/a〉
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  • 5
    Publication Date: 2012-08-21
    Description: Inflammation alters host physiology to promote cancer, as seen in colitis-associated colorectal cancer (CRC). Here, we identify the intestinal microbiota as a target of inflammation that affects the progression of CRC. High-throughput sequencing revealed that inflammation modifies gut microbial composition in colitis-susceptible interleukin-10-deficient (Il10(-/-)) mice. Monocolonization with the commensal Escherichia coli NC101 promoted invasive carcinoma in azoxymethane (AOM)-treated Il10(-/-) mice. Deletion of the polyketide synthase (pks) genotoxic island from E. coli NC101 decreased tumor multiplicity and invasion in AOM/Il10(-/-) mice, without altering intestinal inflammation. Mucosa-associated pks(+) E. coli were found in a significantly high percentage of inflammatory bowel disease and CRC patients. This suggests that in mice, colitis can promote tumorigenesis by altering microbial composition and inducing the expansion of microorganisms with genotoxic capabilities.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645302/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645302/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arthur, Janelle C -- Perez-Chanona, Ernesto -- Muhlbauer, Marcus -- Tomkovich, Sarah -- Uronis, Joshua M -- Fan, Ting-Jia -- Campbell, Barry J -- Abujamel, Turki -- Dogan, Belgin -- Rogers, Arlin B -- Rhodes, Jonathan M -- Stintzi, Alain -- Simpson, Kenneth W -- Hansen, Jonathan J -- Keku, Temitope O -- Fodor, Anthony A -- Jobin, Christian -- MOP114872/Canadian Institutes of Health Research/Canada -- P30 CA016086/CA/NCI NIH HHS/ -- P30 DK034987/DK/NIDDK NIH HHS/ -- P40 R018603/PHS HHS/ -- R01 CA136887/CA/NCI NIH HHS/ -- R01 DK047700/DK/NIDDK NIH HHS/ -- R01 DK073338/DK/NIDDK NIH HHS/ -- R01 DK47700/DK/NIDDK NIH HHS/ -- R01 DK53347-11/DK/NIDDK NIH HHS/ -- R01 DK73338/DK/NIDDK NIH HHS/ -- T32 DK007737/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2012 Oct 5;338(6103):120-3. doi: 10.1126/science.1224820. Epub 2012 Aug 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Pharmacology and Immunology-Microbiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22903521" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Azoxymethane/toxicity ; Carcinogens/toxicity ; Carcinoma/chemically induced/*microbiology/pathology ; Cell Transformation, Neoplastic/genetics/pathology ; Colitis/*complications/genetics ; Colorectal Neoplasms/chemically induced/*microbiology/pathology ; *DNA Damage ; Escherichia coli/genetics/pathogenicity ; Interleukin-10/genetics ; Intestines/*microbiology/pathology ; Metagenome/genetics/*physiology ; Mice ; Mice, Mutant Strains ; Polyketide Synthases/genetics ; Sequence Deletion
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  • 6
    Publication Date: 2013-08-21
    Description: Lignin is a major component of plant secondary cell walls. Here we describe caffeoyl shikimate esterase (CSE) as an enzyme central to the lignin biosynthetic pathway. Arabidopsis thaliana cse mutants deposit less lignin than do wild-type plants, and the remaining lignin is enriched in p-hydroxyphenyl units. Phenolic metabolite profiling identified accumulation of the lignin pathway intermediate caffeoyl shikimate in cse mutants as compared to caffeoyl shikimate levels in the wild type, suggesting caffeoyl shikimate as a substrate for CSE. Accordingly, recombinant CSE hydrolyzed caffeoyl shikimate into caffeate. Associated with the changes in lignin, the conversion of cellulose to glucose in cse mutants increased up to fourfold as compared to that in the wild type upon saccharification without pretreatment. Collectively, these data necessitate the revision of currently accepted models of the lignin biosynthetic pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vanholme, Ruben -- Cesarino, Igor -- Rataj, Katarzyna -- Xiao, Yuguo -- Sundin, Lisa -- Goeminne, Geert -- Kim, Hoon -- Cross, Joanna -- Morreel, Kris -- Araujo, Pedro -- Welsh, Lydia -- Haustraete, Jurgen -- McClellan, Christopher -- Vanholme, Bartel -- Ralph, John -- Simpson, Gordon G -- Halpin, Claire -- Boerjan, Wout -- BB/G016232/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2013 Sep 6;341(6150):1103-6. doi: 10.1126/science.1241602. Epub 2013 Aug 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Systems Biology, VIB (Flanders Institute for Biotechnology), Technologiepark 927, B-9052 Ghent, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23950498" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/*enzymology/genetics ; Arabidopsis Proteins/*chemistry/genetics ; Carboxylic Ester Hydrolases/*chemistry/genetics ; Glucose/chemistry ; Lignin/*biosynthesis ; Metabolic Networks and Pathways ; Mutation ; Shikimic Acid/chemistry ; Substrate Specificity
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  • 7
    Publication Date: 2014-04-26
    Description: Light is a source of energy and also a regulator of plant physiological adaptations. We show here that light/dark conditions affect alternative splicing of a subset of Arabidopsis genes preferentially encoding proteins involved in RNA processing. The effect requires functional chloroplasts and is also observed in roots when the communication with the photosynthetic tissues is not interrupted, suggesting that a signaling molecule travels through the plant. Using photosynthetic electron transfer inhibitors with different mechanisms of action, we deduce that the reduced pool of plastoquinones initiates a chloroplast retrograde signaling that regulates nuclear alternative splicing and is necessary for proper plant responses to varying light conditions.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382720/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382720/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petrillo, Ezequiel -- Godoy Herz, Micaela A -- Fuchs, Armin -- Reifer, Dominik -- Fuller, John -- Yanovsky, Marcelo J -- Simpson, Craig -- Brown, John W S -- Barta, Andrea -- Kalyna, Maria -- Kornblihtt, Alberto R -- BB/G024979/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- P 26333/Austrian Science Fund FWF/Austria -- Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2014 Apr 25;344(6182):427-30. doi: 10.1126/science.1250322. Epub 2014 Apr 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiologia, Biologia Molecular y Celular, IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, C1428EHA Buenos Aires, Argentina.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24763593" target="_blank"〉PubMed〈/a〉
    Keywords: *Alternative Splicing ; Arabidopsis/*genetics/metabolism ; Arabidopsis Proteins/genetics/metabolism ; Cell Nucleus/genetics ; Chloroplasts/*metabolism ; Circadian Clocks ; Dibromothymoquinone/pharmacology ; Diuron/pharmacology ; Electron Transport/drug effects ; *Gene Expression Regulation, Plant ; Light ; Models, Biological ; Oxidation-Reduction ; Photosynthesis/drug effects ; Plant Leaves/metabolism ; Plant Roots/metabolism ; Plants, Genetically Modified ; Plastoquinone/*metabolism ; RNA Stability ; RNA, Messenger/genetics/metabolism ; RNA, Plant/genetics/metabolism ; Seedlings/genetics/metabolism ; Signal Transduction
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