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  • American Association for the Advancement of Science (AAAS)
  • 2010-2014  (28)
  • 1985-1989  (6)
  • 1
    Publication Date: 2011-10-08
    Description: We report the detection of pulsed gamma rays from the Crab pulsar at energies above 100 giga-electron volts (GeV) with the Very Energetic Radiation Imaging Telescope Array System (VERITAS) array of atmospheric Cherenkov telescopes. The detection cannot be explained on the basis of current pulsar models. The photon spectrum of pulsed emission between 100 mega-electron volts and 400 GeV is described by a broken power law that is statistically preferred over a power law with an exponential cutoff. It is unlikely that the observation can be explained by invoking curvature radiation as the origin of the observed gamma rays above 100 GeV. Our findings require that these gamma rays be produced more than 10 stellar radii from the neutron star.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉VERITAS Collaboration -- Aliu, E -- Arlen, T -- Aune, T -- Beilicke, M -- Benbow, W -- Bouvier, A -- Bradbury, S M -- Buckley, J H -- Bugaev, V -- Byrum, K -- Cannon, A -- Cesarini, A -- Christiansen, J L -- Ciupik, L -- Collins-Hughes, E -- Connolly, M P -- Cui, W -- Dickherber, R -- Duke, C -- Errando, M -- Falcone, A -- Finley, J P -- Finnegan, G -- Fortson, L -- Furniss, A -- Galante, N -- Gall, D -- Gibbs, K -- Gillanders, G H -- Godambe, S -- Griffin, S -- Grube, J -- Guenette, R -- Gyuk, G -- Hanna, D -- Holder, J -- Huan, H -- Hughes, G -- Hui, C M -- Humensky, T B -- Imran, A -- Kaaret, P -- Karlsson, N -- Kertzman, M -- Kieda, D -- Krawczynski, H -- Krennrich, F -- Lang, M J -- Lyutikov, M -- Madhavan, A S -- Maier, G -- Majumdar, P -- McArthur, S -- McCann, A -- McCutcheon, M -- Moriarty, P -- Mukherjee, R -- Nunez, P -- Ong, R A -- Orr, M -- Otte, A N -- Park, N -- Perkins, J S -- Pizlo, F -- Pohl, M -- Prokoph, H -- Quinn, J -- Ragan, K -- Reyes, L C -- Reynolds, P T -- Roache, E -- Rose, H J -- Ruppel, J -- Saxon, D B -- Schroedter, M -- Sembroski, G H -- Senturk, G D -- Smith, A W -- Staszak, D -- Tesic, G -- Theiling, M -- Thibadeau, S -- Tsurusaki, K -- Tyler, J -- Varlotta, A -- Vassiliev, V V -- Vincent, S -- Vivier, M -- Wakely, S P -- Ward, J E -- Weekes, T C -- Weinstein, A -- Weisgarber, T -- Williams, D A -- Zitzer, B -- New York, N.Y. -- Science. 2011 Oct 7;334(6052):69-72. doi: 10.1126/science.1208192.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics and Astronomy, Barnard College, Columbia University, NY 10027, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21980105" target="_blank"〉PubMed〈/a〉
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  • 2
    Publication Date: 1988-11-25
    Description: The evolution of worker behavior in the social insects is usually explained by kin selection: although workers do not produce offspring, they do reproduce their genes by aiding the reproduction of relatives. The most difficult case for kin selection theory would be species in which workers are fully capable of reproducing but instead opt to rear brood of low relatedness. These conditions are perhaps best fulfilled by the swarm-founding wasps because they have little caste differentiation and their colonies usually have multiple queens, which should lower relatedness. Estimates of within-colony relatedness for three species in this group confirm that it is sometimes (but not always) very low. Inbreeding is negligible in these species, so the hypothesis that inbreeding may raise relatedness is not supported. The maintenance of worker behavior in such species is a significant challenge for kin selection theory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Queller, D C -- Strassmann, J E -- Hughes, C R -- New York, N.Y. -- Science. 1988 Nov 25;242(4882):1155-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17799732" target="_blank"〉PubMed〈/a〉
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  • 3
    Publication Date: 1989-11-03
    Description: A complementary DNA (cDNA) for ubiquitin carboxyl-terminal hydrolase isozyme L3 was cloned from human B cells. The cDNA encodes a protein of 230 amino acids with a molecular mass of 26.182 daltons. The human protein is very similar to the bovine homolog, with only three amino acids differing in over 100 residues compared. The amino acid sequence deduced from the cDNA was 54% identical to that of the neuron-specific protein PGP 9.5. Purification of bovine PGP 9.5 confirmed that it is also a ubiquitin carboxyl-terminal hydrolase. These results suggest that a family of such related proteins exists and that their expression is tissue-specific.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilkinson, K D -- Lee, K M -- Deshpande, S -- Duerksen-Hughes, P -- Boss, J M -- Pohl, J -- New York, N.Y. -- Science. 1989 Nov 3;246(4930):670-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2530630" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; B-Lymphocytes/enzymology ; Base Sequence ; Cattle ; DNA/genetics ; Humans ; Isoenzymes/genetics ; Molecular Sequence Data ; Neuropeptides/*genetics/isolation & purification ; Sequence Homology, Nucleic Acid ; Thiolester Hydrolases/*genetics/isolation & purification ; Ubiquitin Thiolesterase
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  • 4
    Publication Date: 2010-12-15
    Description: Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes for assimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution toward obligate biotrophy.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971456/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971456/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baxter, Laura -- Tripathy, Sucheta -- Ishaque, Naveed -- Boot, Nico -- Cabral, Adriana -- Kemen, Eric -- Thines, Marco -- Ah-Fong, Audrey -- Anderson, Ryan -- Badejoko, Wole -- Bittner-Eddy, Peter -- Boore, Jeffrey L -- Chibucos, Marcus C -- Coates, Mary -- Dehal, Paramvir -- Delehaunty, Kim -- Dong, Suomeng -- Downton, Polly -- Dumas, Bernard -- Fabro, Georgina -- Fronick, Catrina -- Fuerstenberg, Susan I -- Fulton, Lucinda -- Gaulin, Elodie -- Govers, Francine -- Hughes, Linda -- Humphray, Sean -- Jiang, Rays H Y -- Judelson, Howard -- Kamoun, Sophien -- Kyung, Kim -- Meijer, Harold -- Minx, Patrick -- Morris, Paul -- Nelson, Joanne -- Phuntumart, Vipa -- Qutob, Dinah -- Rehmany, Anne -- Rougon-Cardoso, Alejandra -- Ryden, Peter -- Torto-Alalibo, Trudy -- Studholme, David -- Wang, Yuanchao -- Win, Joe -- Wood, Jo -- Clifton, Sandra W -- Rogers, Jane -- Van den Ackerveken, Guido -- Jones, Jonathan D G -- McDowell, John M -- Beynon, Jim -- Tyler, Brett M -- 079643/Wellcome Trust/United Kingdom -- BB/C509123/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- BB/E007120/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- BB/E024815/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- BB/E024882/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- BB/F0161901/Biotechnology and Biological Sciences Research Council/United Kingdom -- BB/G015244/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- EP/F500025/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- T12144/Biotechnology and Biological Sciences Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2010 Dec 10;330(6010):1549-51. doi: 10.1126/science.1195203.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Life Sciences, Warwick University, Wellesbourne, CV35 9EF, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21148394" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Amino Acid Sequence ; Arabidopsis/*parasitology ; Enzymes/genetics ; *Evolution, Molecular ; Gene Dosage ; Genes ; *Genome ; Host-Pathogen Interactions ; Metabolic Networks and Pathways/genetics ; Molecular Sequence Data ; Oomycetes/*genetics/*growth & development/pathogenicity/physiology ; Phytophthora/genetics ; Plant Diseases/*parasitology ; Polymorphism, Single Nucleotide ; Proteins/genetics ; Selection, Genetic ; Sequence Analysis, DNA ; Spores/physiology ; Synteny ; Virulence Factors/genetics
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  • 5
    Publication Date: 2010-04-03
    Description: The Fermi Gamma-ray Space Telescope has detected the gamma-ray glow emanating from the giant radio lobes of the radio galaxy Centaurus A. The resolved gamma-ray image shows the lobes clearly separated from the central active source. In contrast to all other active galaxies detected so far in high-energy gamma-rays, the lobe flux constitutes a considerable portion (greater than one-half) of the total source emission. The gamma-ray emission from the lobes is interpreted as inverse Compton-scattered relic radiation from the cosmic microwave background, with additional contribution at higher energies from the infrared-to-optical extragalactic background light. These measurements provide gamma-ray constraints on the magnetic field and particle energy content in radio galaxy lobes, as well as a promising method to probe the cosmic relic photon fields.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fermi-LAT Collaboration -- Abdo, A A -- Ackermann, M -- Ajello, M -- Atwood, W B -- Baldini, L -- Ballet, J -- Barbiellini, G -- Bastieri, D -- Baughman, B M -- Bechtol, K -- Bellazzini, R -- Berenji, B -- Blandford, R D -- Bloom, E D -- Bonamente, E -- Borgland, A W -- Bregeon, J -- Brez, A -- Brigida, M -- Bruel, P -- Burnett, T H -- Buson, S -- Caliandro, G A -- Cameron, R A -- Caraveo, P A -- Casandjian, J M -- Cavazzuti, E -- Cecchi, C -- Celik, O -- Chekhtman, A -- Cheung, C C -- Chiang, J -- Ciprini, S -- Claus, R -- Cohen-Tanugi, J -- Colafrancesco, S -- Cominsky, L R -- Conrad, J -- Costamante, L -- Cutini, S -- Davis, D S -- Dermer, C D -- de Angelis, A -- de Palma, F -- Digel, S W -- do Couto e Silva, E -- Drell, P S -- Dubois, R -- Dumora, D -- Farnier, C -- Favuzzi, C -- Fegan, S J -- Finke, J -- Focke, W B -- Fortin, P -- Fukazawa, Y -- Funk, S -- Fusco, P -- Gargano, F -- Gasparrini, D -- Gehrels, N -- Georganopoulos, M -- Germani, S -- Giebels, B -- Giglietto, N -- Giordano, F -- Giroletti, M -- Glanzman, T -- Godfrey, G -- Grenier, I A -- Grove, J E -- Guillemot, L -- Guiriec, S -- Hanabata, Y -- Harding, A K -- Hayashida, M -- Hays, E -- Hughes, R E -- Jackson, M S -- Johannesson, G -- Johnson, A S -- Johnson, T J -- Johnson, W N -- Kamae, T -- Katagiri, H -- Kataoka, J -- Kawai, N -- Kerr, M -- Knodlseder, J -- Kocian, M L -- Kuss, M -- Lande, J -- Latronico, L -- Lemoine-Goumard, M -- Longo, F -- Loparco, F -- Lott, B -- Lovellette, M N -- Lubrano, P -- Madejski, G M -- Makeev, A -- Mazziotta, M N -- McConville, W -- McEnery, J E -- Meurer, C -- Michelson, P F -- Mitthumsiri, W -- Mizuno, T -- Moiseev, A A -- Monte, C -- Monzani, M E -- Morselli, A -- Moskalenko, I V -- Murgia, S -- Nolan, P L -- Norris, J P -- Nuss, E -- Ohsugi, T -- Omodei, N -- Orlando, E -- Ormes, J F -- Paneque, D -- Parent, D -- Pelassa, V -- Pepe, M -- Pesce-Rollins, M -- Piron, F -- Porter, T A -- Raino, S -- Rando, R -- Razzano, M -- Razzaque, S -- Reimer, A -- Reimer, O -- Reposeur, T -- Ritz, S -- Rochester, L S -- Rodriguez, A Y -- Romani, R W -- Roth, M -- Ryde, F -- Sadrozinski, H F-W -- Sambruna, R -- Sanchez, D -- Sander, A -- Saz Parkinson, P M -- Scargle, J D -- Sgro, C -- Siskind, E J -- Smith, D A -- Smith, P D -- Spandre, G -- Spinelli, P -- Starck, J-L -- Stawarz, L -- Strickman, M S -- Suson, D J -- Tajima, H -- Takahashi, H -- Takahashi, T -- Tanaka, T -- Thayer, J B -- Thayer, J G -- Thompson, D J -- Tibaldo, L -- Torres, D F -- Tosti, G -- Tramacere, A -- Uchiyama, Y -- Usher, T L -- Vasileiou, V -- Vilchez, N -- Vitale, V -- Waite, A P -- Wallace, E -- Wang, P -- Winer, B L -- Wood, K S -- Ylinen, T -- Ziegler, M -- Hardcastle, M J -- Kazanas, D -- New York, N.Y. -- Science. 2010 May 7;328(5979):725-9. doi: 10.1126/science.1184656. Epub 2010 Apr 1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20360067" target="_blank"〉PubMed〈/a〉
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  • 6
    Publication Date: 2010-08-14
    Description: Novae are thermonuclear explosions on a white dwarf surface fueled by mass accreted from a companion star. Current physical models posit that shocked expanding gas from the nova shell can produce x-ray emission, but emission at higher energies has not been widely expected. Here, we report the Fermi Large Area Telescope detection of variable gamma-ray emission (0.1 to 10 billion electron volts) from the recently detected optical nova of the symbiotic star V407 Cygni. We propose that the material of the nova shell interacts with the dense ambient medium of the red giant primary and that particles can be accelerated effectively to produce pi(0) decay gamma-rays from proton-proton interactions. Emission involving inverse Compton scattering of the red giant radiation is also considered and is not ruled out.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fermi-LAT Collaboration -- Abdo, A A -- Ackermann, M -- Ajello, M -- Atwood, W B -- Baldini, L -- Ballet, J -- Barbiellini, G -- Bastieri, D -- Bechtol, K -- Bellazzini, R -- Berenji, B -- Blandford, R D -- Bloom, E D -- Bonamente, E -- Borgland, A W -- Bouvier, A -- Brandt, T J -- Bregeon, J -- Brez, A -- Brigida, M -- Bruel, P -- Buehler, R -- Burnett, T H -- Buson, S -- Caliandro, G A -- Cameron, R A -- Caraveo, P A -- Carrigan, S -- Casandjian, J M -- Cecchi, C -- Celik, O -- Charles, E -- Chaty, S -- Chekhtman, A -- Cheung, C C -- Chiang, J -- Ciprini, S -- Claus, R -- Cohen-Tanugi, J -- Conrad, J -- Corbel, S -- Corbet, R -- DeCesar, M E -- den Hartog, P R -- Dermer, C D -- de Palma, F -- Digel, S W -- Donato, D -- do Couto e Silva, E -- Drell, P S -- Dubois, R -- Dubus, G -- Dumora, D -- Favuzzi, C -- Fegan, S J -- Ferrara, E C -- Fortin, P -- Frailis, M -- Fuhrmann, L -- Fukazawa, Y -- Funk, S -- Fusco, P -- Gargano, F -- Gasparrini, D -- Gehrels, N -- Germani, S -- Giglietto, N -- Giordano, F -- Giroletti, M -- Glanzman, T -- Godfrey, G -- Grenier, I A -- Grondin, M-H -- Grove, J E -- Guiriec, S -- Hadasch, D -- Harding, A K -- Hayashida, M -- Hays, E -- Healey, S E -- Hill, A B -- Horan, D -- Hughes, R E -- Itoh, R -- Jean, P -- Johannesson, G -- Johnson, A S -- Johnson, R P -- Johnson, T J -- Johnson, W N -- Kamae, T -- Katagiri, H -- Kataoka, J -- Kerr, M -- Knodlseder, J -- Koerding, E -- Kuss, M -- Lande, J -- Latronico, L -- Lee, S-H -- Lemoine-Goumard, M -- Garde, M Llena -- Longo, F -- Loparco, F -- Lott, B -- Lovellette, M N -- Lubrano, P -- Makeev, A -- Mazziotta, M N -- McConville, W -- McEnery, J E -- Mehault, J -- Michelson, P F -- Mizuno, T -- Moiseev, A A -- Monte, C -- Monzani, M E -- Morselli, A -- Moskalenko, I V -- Murgia, S -- Nakamori, T -- Naumann-Godo, M -- Nestoras, I -- Nolan, P L -- Norris, J P -- Nuss, E -- Ohno, M -- Ohsugi, T -- Okumura, A -- Omodei, N -- Orlando, E -- Ormes, J F -- Ozaki, M -- Paneque, D -- Panetta, J H -- Parent, D -- Pelassa, V -- Pepe, M -- Pesce-Rollins, M -- Piron, F -- Porter, T A -- Raino, S -- Rando, R -- Ray, P S -- Razzano, M -- Razzaque, S -- Rea, N -- Reimer, A -- Reimer, O -- Reposeur, T -- Ripken, J -- Ritz, S -- Romani, R W -- Roth, M -- Sadrozinski, H F-W -- Sander, A -- Parkinson, P M Saz -- Scargle, J D -- Schinzel, F K -- Sgro, C -- Shaw, M S -- Siskind, E J -- Smith, D A -- Smith, P D -- Sokolovsky, K V -- Spandre, G -- Spinelli, P -- Stawarz, L -- Strickman, M S -- Suson, D J -- Takahashi, H -- Takahashi, T -- Tanaka, T -- Tanaka, Y -- Thayer, J B -- Thayer, J G -- Thompson, D J -- Tibaldo, L -- Torres, D F -- Tosti, G -- Tramacere, A -- Uchiyama, Y -- Usher, T L -- Vandenbroucke, J -- Vasileiou, V -- Vilchez, N -- Vitale, V -- Waite, A P -- Wallace, E -- Wang, P -- Winer, B L -- Wolff, M T -- Wood, K S -- Yang, Z -- Ylinen, T -- Ziegler, M -- Maehara, H -- Nishiyama, K -- Kabashima, F -- Bach, U -- Bower, G C -- Falcone, A -- Forster, J R -- Henden, A -- Kawabata, K S -- Koubsky, P -- Mukai, K -- Nelson, T -- Oates, S R -- Sakimoto, K -- Sasada, M -- Shenavrin, V I -- Shore, S N -- Skinner, G K -- Sokoloski, J -- Stroh, M -- Tatarnikov, A M -- Uemura, M -- Wahlgren, G M -- Yamanaka, M -- New York, N.Y. -- Science. 2010 Aug 13;329(5993):817-21. doi: 10.1126/science.1192537.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Space Science Division, Naval Research Laboratory, Washington, DC 20375, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20705855" target="_blank"〉PubMed〈/a〉
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  • 7
    Publication Date: 2010-01-09
    Description: Recent observations of supernova remnants (SNRs) hint that they accelerate cosmic rays to energies close to ~10(15) electron volts. However, the nature of the particles that produce the emission remains ambiguous. We report observations of SNR W44 with the Fermi Large Area Telescope at energies between 2 x 10(8) electron volts and 3 x10(11) electron volts. The detection of a source with a morphology corresponding to the SNR shell implies that the emission is produced by particles accelerated there. The gamma-ray spectrum is well modeled with emission from protons and nuclei. Its steepening above approximately 10(9) electron volts provides a probe with which to study how particle acceleration responds to environmental effects such as shock propagation in dense clouds and how accelerated particles are released into interstellar space.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abdo, A A -- Ackermann, M -- Ajello, M -- Baldini, L -- Ballet, J -- Barbiellini, G -- Baring, M G -- Bastieri, D -- Baughman, B M -- Bechtol, K -- Bellazzini, R -- Berenji, B -- Blandford, R D -- Bloom, E D -- Bonamente, E -- Borgland, A W -- Bregeon, J -- Brez, A -- Brigida, M -- Bruel, P -- Burnett, T H -- Buson, S -- Caliandro, G A -- Cameron, R A -- Caraveo, P A -- Casandjian, J M -- Cecchi, C -- Celik, O -- Chekhtman, A -- Cheung, C C -- Chiang, J -- Ciprini, S -- Claus, R -- Cognard, I -- Cohen-Tanugi, J -- Cominsky, L R -- Conrad, J -- Cutini, S -- Dermer, C D -- de Angelis, A -- de Palma, F -- Digel, S W -- do Couto e Silva, E -- Drell, P S -- Dubois, R -- Dumora, D -- Espinoza, C -- Farnier, C -- Favuzzi, C -- Fegan, S J -- Focke, W B -- Fortin, P -- Frailis, M -- Fukazawa, Y -- Funk, S -- Fusco, P -- Gargano, F -- Gasparrini, D -- Gehrels, N -- Germani, S -- Giavitto, G -- Giebels, B -- Giglietto, N -- Giordano, F -- Glanzman, T -- Godfrey, G -- Grenier, I A -- Grondin, M-H -- Grove, J E -- Guillemot, L -- Guiriec, S -- Hanabata, Y -- Harding, A K -- Hayashida, M -- Hays, E -- Hughes, R E -- Jackson, M S -- Johannesson, G -- Johnson, A S -- Johnson, T J -- Johnson, W N -- Kamae, T -- Katagiri, H -- Kataoka, J -- Katsuta, J -- Kawai, N -- Kerr, M -- Knodlseder, J -- Kocian, M L -- Kramer, M -- Kuss, M -- Lande, J -- Latronico, L -- Lemoine-Goumard, M -- Longo, F -- Loparco, F -- Lott, B -- Lovellette, M N -- Lubrano, P -- Lyne, A G -- Madejski, G M -- Makeev, A -- Mazziotta, M N -- McEnery, J E -- Meurer, C -- Michelson, P F -- Mitthumsiri, W -- Mizuno, T -- Monte, C -- Monzani, M E -- Morselli, A -- Moskalenko, I V -- Murgia, S -- Nakamori, T -- Nolan, P L -- Norris, J P -- Noutsos, A -- Nuss, E -- Ohsugi, T -- Omodei, N -- Orlando, E -- Ormes, J F -- Paneque, D -- Parent, D -- Pelassa, V -- Pepe, M -- Pesce-Rollins, M -- Piron, F -- Porter, T A -- Raino, S -- Rando, R -- Razzano, M -- Reimer, A -- Reimer, O -- Reposeur, T -- Rochester, L S -- Rodriguez, A Y -- Romani, R W -- Roth, M -- Ryde, F -- Sadrozinski, H F-W -- Sanchez, D -- Sander, A -- Saz Parkinson, P M -- Scargle, J D -- Sgro, C -- Siskind, E J -- Smith, D A -- Smith, P D -- Spandre, G -- Spinelli, P -- Stappers, B W -- Stecker, F W -- Strickman, M S -- Suson, D J -- Tajima, H -- Takahashi, H -- Takahashi, T -- Tanaka, T -- Thayer, J B -- Thayer, J G -- Theureau, G -- Thompson, D J -- Tibaldo, L -- Tibolla, O -- Torres, D F -- Tosti, G -- Tramacere, A -- Uchiyama, Y -- Usher, T L -- Vasileiou, V -- Venter, C -- Vilchez, N -- Vitale, V -- Waite, A P -- Wang, P -- Winer, B L -- Wood, K S -- Yamazaki, R -- Ylinen, T -- Ziegler, M -- New York, N.Y. -- Science. 2010 Feb 26;327(5969):1103-6. doi: 10.1126/science.1182787. Epub 2010 Jan 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Space Science Division, Naval Research Laboratory, Washington, DC 20375, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20056857" target="_blank"〉PubMed〈/a〉
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  • 8
    Publication Date: 2010-05-22
    Description: Self-assembled nanostructures obtained from natural and synthetic amphiphiles serve as mimics of biological membranes and enable the delivery of drugs, proteins, genes, and imaging agents. Yet the precise molecular arrangements demanded by these functions are difficult to achieve. Libraries of amphiphilic Janus dendrimers, prepared by facile coupling of tailored hydrophilic and hydrophobic branched segments, have been screened by cryogenic transmission electron microscopy, revealing a rich palette of morphologies in water, including vesicles, denoted dendrimersomes, cubosomes, disks, tubular vesicles, and helical ribbons. Dendrimersomes marry the stability and mechanical strength obtainable from polymersomes with the biological function of stabilized phospholipid liposomes, plus superior uniformity of size, ease of formation, and chemical functionalization. This modular synthesis strategy provides access to systematic tuning of molecular structure and of self-assembled architecture.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Percec, Virgil -- Wilson, Daniela A -- Leowanawat, Pawaret -- Wilson, Christopher J -- Hughes, Andrew D -- Kaucher, Mark S -- Hammer, Daniel A -- Levine, Dalia H -- Kim, Anthony J -- Bates, Frank S -- Davis, Kevin P -- Lodge, Timothy P -- Klein, Michael L -- DeVane, Russell H -- Aqad, Emad -- Rosen, Brad M -- Argintaru, Andreea O -- Sienkowska, Monika J -- Rissanen, Kari -- Nummelin, Sami -- Ropponen, Jarmo -- New York, N.Y. -- Science. 2010 May 21;328(5981):1009-14. doi: 10.1126/science.1185547.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323, USA. percec@sas.upenn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20489021" target="_blank"〉PubMed〈/a〉
    Keywords: Antibiotics, Antineoplastic/administration & dosage ; Biomimetic Materials/chemistry ; Cryoelectron Microscopy ; Dendrimers/*chemistry ; Doxorubicin/administration & dosage ; Drug Carriers ; Hydrophobic and Hydrophilic Interactions ; *Membranes, Artificial ; Models, Molecular ; Molecular Dynamics Simulation ; Molecular Structure ; *Nanostructures ; Surface Properties ; Surface-Active Agents/chemistry ; Water
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2011-09-10
    Description: Manipulation of host behavior by parasites and pathogens has been widely observed, but the basis for these behaviors has remained elusive. Gypsy moths infected by a baculovirus climb to the top of trees to die, liquefy, and "rain" virus on the foliage below to infect new hosts. The viral gene that manipulates climbing behavior of the host was identified, providing evidence of a genetic basis for the extended phenotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoover, Kelli -- Grove, Michael -- Gardner, Matthew -- Hughes, David P -- McNeil, James -- Slavicek, James -- New York, N.Y. -- Science. 2011 Sep 9;333(6048):1401. doi: 10.1126/science.1209199.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Entomology and Center for Chemical Ecology, Pennsylvania State University, University Park, PA 16802, USA. kxh25@psu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21903803" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal ; Gene Deletion ; *Genes, Viral ; Glucosyltransferases/*genetics/metabolism ; Larva/physiology/virology ; Moths/*physiology/*virology ; Motor Activity ; Nucleopolyhedrovirus/*genetics/physiology ; Phenotype ; Viral Proteins/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2011-01-29
    Description: Understanding ancient climate changes is hampered by the inability to disentangle trends in ocean temperature from trends in continental ice volume. We used carbonate "clumped" isotope paleothermometry to constrain ocean temperatures, and thereby estimate ice volumes, through the Late Ordovician-Early Silurian glaciation. We find tropical ocean temperatures of 32 degrees to 37 degrees C except for short-lived cooling by ~5 degrees C during the final Ordovician stage. Evidence for ice sheets spans much of the study interval, but the cooling pulse coincided with a glacial maximum during which ice volumes likely equaled or exceeded those of the last (Pleistocene) glacial maximum. This cooling also coincided with a large perturbation of the carbon cycle and the Late Ordovician mass extinction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Finnegan, Seth -- Bergmann, Kristin -- Eiler, John M -- Jones, David S -- Fike, David A -- Eisenman, Ian -- Hughes, Nigel C -- Tripati, Aradhna K -- Fischer, Woodward W -- New York, N.Y. -- Science. 2011 Feb 18;331(6019):903-6. doi: 10.1126/science.1200803. Epub 2011 Jan 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125, USA. sethf@caltech.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21273448" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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