Publication Date:
2013-09-19
Description:
Article FGFR2 gene variation is associated with breast cancer risk but the molecular mechanism is unknown. Fletcher et al . provide a link between FGFR2 signalling and breast cancer susceptibility by demonstrating that FGFR2 signalling activates the ERa transcriptional network, which drives transcription of risk genes. Nature Communications doi: 10.1038/ncomms3464 Authors: Michael N. C. Fletcher, Mauro A. A. Castro, Xin Wang, Ines de Santiago, Martin O’Reilly, Suet-Feung Chin, Oscar M. Rueda, Carlos Caldas, Bruce A. J. Ponder, Florian Markowetz, Kerstin B. Meyer
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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