ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 2010-2014  (236)
  • 1975-1979  (41)
Collection
Keywords
Publisher
Years
Year
  • 1
    facet.materialart.
    Unknown
    A genome-wide association study on thyroid function and anti-thyroid peroxidase antibodies in Koreans (2014)
    Oxford University Press
    Details
    Publication Date: 2014-07-19
    Description: Genetic factors are thought to be an important determinant of thyroid function and autoimmunity. However, there are limited data on genetic variants in Asians. In this study, we performed a genome-wide association study on plasma thyroid-stimulating hormone (TSH) and free thyroxine (fT 4 ) concentration and anti-thyroid peroxidase (anti-TPO) antibody positivity in 4238 Korean subjects. In the Stage 1 genome scan, 3396 participants from the Ansung cohort were investigated using 1.42 million genotyped or imputed markers. In the Stage 2 follow-up, 10 markers were genotyped in 842 participants from the Korean Longitudinal Study on Health and Aging cohort. An intronic variant in VAV3, rs12126655, which has been reported in Europeans, was significantly associated with plasma TSH concentration in the joint Stages 1 and 2 analyses ( P = 2.2 x 10 –8 ). We observed that a novel variant, rs2071403, located 75 bp proximal to the translational start site of TPO was significantly associated with plasma anti-TPO antibody positivity in the joint Stages 1 and 2 analyses ( P = 1.3 x 10 –10 ). This variant had a marginal sex-specific effect, and its association was more significant in females. Subjects possessing the rs2071403A allele, associated with an absence of the anti-TPO antibody, had decreased TPO mRNA expression in their thyroid tissue. Another intronic variant of HLA-DPB2 , rs733208, had a suggestive association with anti-TPO antibody positivity ( P = 4.2 x 10 –7 ). In conclusion, we have identified genetic variants that are strongly associated with TSH level and anti-TPO antibody positivity in Koreans. Further replications and meta-analysis are required to confirm these findings.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Interactomic inhibition of transcription factor [Immunology and Inflammation] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-12-31
    Description: The nuclear hormone receptor retinoic acid-related orphan receptor gamma t (RORγt) is a transcription factor (TF) specific to TH17 cells that produce interleukin (IL)-17 and have been implicated in a wide range of autoimmunity. Here, we developed a novel therapeutic strategy to modulate the functions of RORγt using cell-transducible form...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    The structural basis for receptor recognition of human interleukin-18 (2014)
    Springer Nature
    Details
    Publication Date: 2014-12-17
    Description: Article IL-18 is a member of the IL-1 family of proinflammatory cytokines. Tsutsumi et al. present a crystal structure of IL-18 bound to the extracellular domains of its heterodimeric receptor, providing insight into how its unusual specificity may be targeted pharmacologically. Nature Communications doi: 10.1038/ncomms6340 Authors: Naotaka Tsutsumi, Takeshi Kimura, Kyohei Arita, Mariko Ariyoshi, Hidenori Ohnishi, Takahiro Yamamoto, Xiaobing Zuo, Katsumi Maenaka, Enoch Y. Park, Naomi Kondo, Masahiro Shirakawa, Hidehito Tochio, Zenichiro Kato
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    ES cell-derived renewable and functional midbrain dopaminergic progenitors [Neuroscience] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-06-08
    Description: During early development, midbrain dopaminergic (mDA) neuronal progenitors (NPs) arise from the ventral mesencephalic area by the combined actions of secreted factors and their downstream transcription factors. These mDA NPs proliferate, migrate to their final destinations, and develop into mature mDA neurons in the substantia nigra and the ventral tegmental area. Here, we show that such authentic mDA NPs can be efficiently isolated from differentiated ES cells (ESCs) using a FACS method combining two markers, Otx2 and Corin. Purified Otx2+Corin+ cells coexpressed other mDA NP markers, including FoxA2, Lmx1b, and Glast. Using optimized culture conditions, these mDA NPs continuously proliferated up to 4 wk with almost 1,000-fold expansion without significant changes in their phenotype. Furthermore, upon differentiation, Otx2+Corin+ cells efficiently generated mDA neurons, as evidenced by coexpression of mDA neuronal markers (e.g., TH, Pitx3, Nurr1, and Lmx1b) and physiological functions (e.g., efficient DA secretion and uptake). Notably, these mDA NPs differentiated into a relatively homogenous DA population with few serotonergic neurons. When transplanted into PD model animals, aphakia mice, and 6-OHDA–lesioned rats, mDA NPs differentiated into mDA neurons in vivo and generated well-integrated DA grafts, resulting in significant improvement in motor dysfunctions without tumor formation. Furthermore, grafted Otx2+Corin+ cells exhibited significant migratory function in the host striatum, reaching 〉3.3 mm length in the entire striatum. We propose that functional and expandable mDA NPs can be efficiently isolated by this unique strategy and will serve as useful tools in regenerative medicine, bioassay, and drug screening.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    HSP90 functions in the circadian clock through stabilization of the client F-box protein ZEITLUPE [Plant Biology] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-10-05
    Description: The autoregulatory loops of the circadian clock consist of feedback regulation of transcription/translation circuits but also require finely coordinated cytoplasmic and nuclear proteostasis. Although protein degradation is important to establish steady-state levels, maturation into their active conformation also factors into protein homeostasis. HSP90 facilitates the maturation of a wide range of client proteins, and studies in metazoan clocks implicate HSP90 as an integrator of input or output. Here we show that the Arabidopsis circadian clock-associated F-box protein ZEITLUPE (ZTL) is a unique client for cytoplasmic HSP90. The HSP90-specific inhibitor geldanamycin and RNAi-mediated depletion of cytoplasmic HSP90 reduces levels of ZTL and lengthens circadian period, consistent with ztl loss-of-function alleles. Transient transfection of artificial microRNA targeting cytoplasmic HSP90 genes similarly lengthens period. Proteolytic targets of SCFZTL, TOC1 and PRR5, are stabilized in geldanamycin-treated seedlings, whereas the levels of closely related clock proteins, PRR3 and PRR7, are unchanged. An in vitro holdase assay, typically used to demonstrate chaperone activity, shows that ZTL can be effectively bound, and aggregation prevented, by HSP90. GIGANTEA, a unique stabilizer of ZTL, may act in the same pathway as HSP90, possibly linking these two proteins to a similar mechanism. Our findings establish maturation of ZTL by HSP90 as essential for proper function of the Arabidopsis circadian clock. Unlike metazoan systems, HSP90 functions here within the core oscillator. Additionally, F-box proteins as clients may place HSP90 in a unique and more central role in proteostasis.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    Go2 G protein mediates galanin inhibitory effects on insulin release from pancreatic {beta} cells [Physiology] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-02-15
    Description: The neuropeptide galanin regulates numerous physiological activities in the body, including feeding and metabolism, learning and memory, nociception and spinal reflexes, and anxiety and related behaviors. Modulation of blood glucose levels by suppressing insulin release was the first reported activity for galanin. This inhibition was mediated by one or more pertussis toxin-sensitive G proteins of the Gi/o subfamily. However, the molecular identities of the specific G protein(s) and intracellular effectors have not been fully revealed. Recently, we demonstrated that mice lacking Go2, but not other members of the Gi/o protein family, secrete more insulin than controls upon glucose challenge, indicating that Go2 is a major transducer for the inhibitory regulation of insulin secretion. In this study, we investigated galanin signaling mechanisms in β cells using cell biological and electrophysiological approaches. We found that islets lacking Go2, but not other Gi/o proteins, lose the inhibitory effect of galanin on insulin release. Potentiation of ATP-sensitive potassium (KATP) and inhibition of calcium currents by galanin were disrupted by anti-Go2α antibodies. Galanin actions on KATP and calcium currents were completely lost in Go2−/− β cells. Furthermore, the hyperglycemic effect of galanin is also blunted in Go2−/− mice. Our results demonstrate that Go2 mediates the inhibition of insulin release by galanin by regulating both KATP and Ca2+ channels in mice. Our findings provide insight into galanin's action in glucose homeostasis. The results may also be relevant to the understanding of galanin signaling in other biological systems, especially the central nervous system.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Cap-dependent translation without base-by-base scanning of an messenger ribonucleic acid (2012)
    Oxford University Press
    Details
    Publication Date: 2012-08-23
    Description: ‘Ribosome scanning’ is the generally accepted mechanism for explaining how a ribosome finds an initiation codon located far removed from the ribosome recruiting site (cap structure). However, the molecular characteristics of ribosome scanning along 5' untranslated regions (UTRs) remain obscure. Herein, using a rabbit reticulocyte lysate (RRL) system and artificial ribonucleic acid (RNA) constructs composed of a capped leader RNA and an uncapped reporter RNA annealed through a double-stranded RNA (dsRNA) bridge, we show that the ribosome can efficiently bypass a stable, dsRNA region without melting the structure. The insertion of an upstream open reading frame in the capped leader RNA impaired the translation of reporter RNA, indicating that a ribosome associated with the 5'-end explores the regions upstream of the dsRNA bridge in search of the initiation codon. These data indicate that a ribosome may skip part(s) of an messenger RNA 5'UTR without thoroughly scanning it.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    Subsidence Hazard Assessment at the Samcheok Coalfield, South Korea: A Case Study Using GIS (2013)
    Association of Engineering Geologists (AEG)
    Details
    Publication Date: 2013-02-20
    Description: This paper presents a case study of subsidence hazard assessment using geographic information systems (GIS) in an abandoned coal mine area in South Korea. A spatial database was constructed using mine drift maps, topographic maps, geologic maps, borehole data, and subsidence inventory maps representing the locations of past subsidence occurrences. Eight factor layers (drift depth, drift density, distance from nearest drift, distance from nearest railroad, rock mass rating, groundwater depth, slope, and surface runoff accumulation) were extracted from the spatial database to examine the relationships between the factors and past subsidence occurrences (training data set). A frequency ratio (FR) model was used to establish rating classes for each factor, and an analytic hierarchy process (AHP) model was used to establish weightings for the factors. The two models were integrated to combine multiple factor layers into a subsidence hazard map. When the area under the curve technique was used to verify the subsidence hazard map, by comparing the determined hazard rankings with past subsidence occurrences (validation data set), the FR model and FR-AHP integrated model showed 97 percent and 94 percent accuracies, respectively, in predicting subsidence occurrences. Finally, the subsidence hazard map based on the FR model was overlain with exposure intensity and vulnerability maps to generate a priority setting map, representing the relative risk of mine subsidence to buildings. The priority setting map can be used by planners and developers to identify and prioritize areas requiring more detailed investigations of mine subsidence hazards and risks.
    Print ISSN: 1078-7275
    Topics: Geosciences
    Published by Association of Engineering Geologists (AEG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Identification of functional CNV region networks using a CNV-gene mapping algorithm in a genome-wide scale (2012)
    Oxford University Press
    Details
    Publication Date: 2012-07-21
    Description: Motivation: Identifying functional relation of copy number variation regions (CNVRs) and gene is an essential process in understanding the impact of genotypic variations on phenotype. There have been many related works, but only a few attempts were made to normal populations. Results: To analyze the functions of genome-wide CNVRs, we applied a novel correlation measure called Correlation based on Sample Set (CSS) to paired Whole Genome TilePath array and messenger RNA (mRNA) microarray data from 210 HapMap individuals with normal phenotypes and calculated the confident CNVR–gene relationships. Two CNVR nodes form an edge if they regulate a common set of genes, allowing the construction of a global CNVR network. We performed functional enrichment on the common genes that were trans -regulated from CNVRs clustered together in our CNVR network. As a result, we observed that most of CNVR clusters in our CNVR network were reported to be involved in some biological processes or cellular functions, while most CNVR clusters from randomly constructed CNVR networks showed no evidence of functional enrichment. Those results imply that CSS is capable of finding related CNVR–gene pairs and CNVR networks that have functional significance. Availability: http://embio.yonsei.ac.kr/~ Park/cnv_net.php. Contact: sanghyun@cs.yonsei.ac.kr Supplementary Information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    On near-tail bubble penetration into geosynchronous altitude (2012)
    Wiley
    Details
    Publication Date: 2012-07-07
    Description: Dipolarization of the magnetic field at the near-Earth tail is usually associated with the local reduction of pV5/3 compared to that of the background, where p is the plasma pressure and V is the volume of the unit magnetic flux tube. This can be interpreted as a bubble, which can propagate earthward by the interchange process. How deep such a bubble can penetrate earthward, and what is the critical factor are critical questions that need to be answered. In this paper, we examine these issues by comparing near-tail observations by inner probes of THEMIS with geosynchronous magnetic observations by GOES. We identified a number of bubble events associated with near-tail dipolarization, which we call “tail bubble,” and checked geosynchronous disturbances. We find a statistical trend that geosynchronous disturbance is more likely to occur when associated with (or when hit by) an earthward moving tail bubble with a more-depleted pV5/3. We estimated the background pV5/3 profile statistically and used it to determine expected equilibrium (or stop) positions for earthward moving bubbles where the bubble's pV5/3 is equal to that of the background. Statistically, we find that the equilibrium position is more inward for tail bubbles with a lower pV5/3, for which the probability of causing geosynchronous disturbance is higher. For example, the probability of a tail bubble being associated with geosynchronous disturbance is 75% if the bubble's equilibrium position is 
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...