ALBERT

Description: Depression is a prevalent and debilitating psychiatric illnesses. However, currently prescribed antidepressant drugs are only efficacious in a limited group of patients. Studies on Balb/c mice suggested that histone deacetylase (HDAC) inhibition may enhance the efficacy of the widely-prescribed antidepressant drug fluoxetine. This study shows that reducing HDAC activity in fluoxetine-treated Balb/c mice leads to robust antidepressant and anxiolytic effects. While reducing the activity of class I HDACs 1 and 3 led to antidepressant effects, additional class II HDAC inhibition was necessary to exert anxiolytic effects. In fluoxetine-treated mice, HDAC inhibitors increased enrichment of acetylated histone H4 protein and RNA polymerase II at promotor 3 of the brain-derived neurotrophic factor (Bdnf) gene and increased Bdnf transcription from this promotor. Reducing Bdnf-stimulated tropomyosin kinase B receptor activation in fluoxetine-treated mice with low HDAC activity abolished the behavioral effects of fluoxetine, suggesting that the HDAC-triggered epigenetic stimulation of Bdnf expression is critical for therapeutic efficacy. Scientific Reports 5 doi: 10.1038/srep08171

Description: We demonstrate the application of polymer planar Bragg gratings for multi-axial strain sensing and particularly highlight simultaneous 2D strain measurement. A polymer planar Bragg grating (PPBG) fabricated with a single writing step in bulk polymethylmethacrylate is used for measuring both tensile and compressive strain at various angles. It is shown that the sensitivity of the PPBG strongly depends on the angle between the optical waveguide into which the grating is inscribed and the direction along which the mechanical load is applied. Additionally, a 2D PPBG fabricated by writing two Bragg gratings angularly displaced from each other into a single polymer platelet is bonded to a stainless steel plate. The two reflected wavelengths exhibit different sensitivities while tested toward tensile and compressive strain. These characteristics make 2D PPBG suitable for measuring multi-axial tensile and compressive strain.

Description: Sensors, Vol. 17, Pages 1964: UV-Writing of a Superstructure Waveguide Bragg Grating in a Planar Polymer Substrate Sensors doi: 10.3390/s17091964 Authors: Manuel Rosenberger Bernhard Schmauss Ralf Hellmann We report on the fabrication of a superstructure Bragg grating in a planar polymer substrate. Based on a twofold illumination process an integrated waveguide and a superstructure Bragg grating are subsequently written into bulk polymethylmethacrylate by UV-induced refractive index modification. The measured reflected spectrum of the superstructure Bragg grating exhibits multiple reflection peaks and is in good agreement with performed standard simulations based on the beam propagation method and coupled mode theory algorithms. By applying a varying tensile load we determine the strain sensitivity to be about 1.10 pm/µε and demonstrate the applicability of the superstructure Bragg grating for strain measurements with redundant sensing signals.

Description: Sensors, Vol. 18, Pages 2268: Model-Based Position and Reflectivity Estimation of Fiber Bragg Grating Sensor Arrays Sensors doi: 10.3390/s18072268 Authors: Stefan Werzinger Darko Zibar Max Köppel Bernhard Schmauss We propose an efficient model-based signal processing approach for optical fiber sensing with fiber Bragg grating (FBG) arrays. A position estimation based on an estimation of distribution algorithm (EDA) and a reflectivity estimation method using a parametric transfer matrix model (TMM) are outlined in detail. The estimation algorithms are evaluated with Monte Carlo simulations and measurement data from an incoherent optical frequency domain reflectometer (iOFDR). The model-based approach outperforms conventional Fourier transform processing, especially near the spatial resolution limit, saving electrical bandwidth and measurement time. The models provide great flexibility and can be easily expanded in complexity to meet different topologies and to include prior knowledge of the sensors. Systematic errors due to crosstalk between gratings caused by multiple reflections and spectral shadowing could be further considered with the TMM to improve the performance of large-scale FBG array sensor systems.

Description: Sensors, Vol. 18, Pages 2319: Optical Strain Measurement with Step-Index Polymer Optical Fiber Based on the Phase Measurement of an Intensity-Modulated Signal Sensors doi: 10.3390/s18072319 Authors: Thomas Becker Olaf Ziemann Rainer Engelbrecht Bernhard Schmauss Polymer optical fibers (POFs) have been proposed for optical strain sensors due to their large elastic strain range compared to glass optical fibers (GOFs). The phase response of a single-mode polymer optical fiber (SM-POF) is well-known in the literature, and depends on the physical deformation of the fiber as well as the impact on the refractive index of the core. In this paper, we investigate the impact of strain on a step-index polymer optical fiber (SI-POF). In particular, we discuss the responsivity of an optical strain sensor which is based on the phase measurement of an intensity-modulated signal. In comparison to the phase response of an SM-POF, we must take additional influences into account. Firstly, the SI-POF is a multi-mode fiber (MMF). Consequently, we not only consider the strain dependence of the refractive index, but also its dependency on the propagation angle θz. Second, we investigate the phase of an intensity-modulated signal. The development of this modulation phase along the fiber is influenced by modal dispersion, scattering, and attenuation. The modulation phase therefore has no linear dependency on the length of the fiber, even in the unstrained state. For the proper consideration of these effects, we rely on a novel model for step-index multi-mode fibers (SI-MMFs). We expand the model to consider the strain-induced effects, simulate the strain responsivity of the sensor, and compare it to experimental results. This led to the conclusion that the scattering behavior of a SI-POF is strain-dependent, which was further proven by measuring the far field at the end of a SI-POF under different strain conditions.

Description: Flexible epoxy waveguide Bragg gratings are fabricated on a low-modulus TPX™ polymethylpentene polyolefin substrate for an easy to manufacture and low-cost optomechanical sensor pad providing exceedingly multipurpose application potentials. Rectangular EpoCore negative resist strip waveguides are formed employing standard UV mask lithography. Highly persistent Bragg gratings are inscribed directly into the channel waveguides by permanently modifying the local refractive indices through a well-defined KrF excimer laser irradiated +1/-1 order phase mask. The reproducible and vastly versatile sensing capabilities of this easy-to-apply optomechanical sensor pad are demonstrated in the form of an optical pickup for acoustic instruments, a broadband optical accelerometer, and a biomedical vital sign sensor monitoring both respiration and pulse at the same time.

Description: Step-index polymer optical fibers (SI-POFs) are deployed in both sensing and data transmission systems. The optical transmission behavior of these fibers is complex and affected by intrinsic influences like modal dispersion, scattering and attenuation as well as extrinsic influences like the launching condition and the angular sensitivity of the receiver. Since a proper modeling of the transmission behavior is important in order to evaluate the suitability of the fiber for a specific application, we present a novel model for step-index multi-mode fibers (SI-MMFs) which considers all the previously mentioned impacts. Furthermore, the model differentiates scattering and attenuation for propagating rays not only by their propagating angle θ z but also by the skewness θ ϕ . It is therefore possible to distinguish between guided, tunneling and refracted modes. The model uses scatter and attenuation data from previously published measurements of an SI-POF and computes the impulse response of the transmission system which is transferred to the frequency domain to derive the amplitude and phase response. A possible application for SI-POF is the length or strain measurement of the fiber by measuring the phase of a harmonically modulated signal. These sensors rely on a linear relation between the length of the fiber and the phase of the modulated signal. We demonstrate the application of the model by simulating the length measurement error that occurs for these sensors by obtaining the phase response for the corresponding optical transmission system. Furthermore, we will demonstrate the flexibility of the model by varying several influences including the excitation of different mode categories and evaluate the impact on the measurement error. Finally, we compare the simulated length error derived from the model to real data obtained from a cutback measurement. An implementation of the model, which was used for all simulations in this paper, is publicly available.

Description: We apply a fast terahertz time-domain spectroscopy (TDS) system based on electronically controlled optical sampling (ECOPS) to contact-free thickness gauging. Our setup achieves a measurement speed of 1600 terahertz pulse traces per second, which—to our knowledge—represents the fastest thickness measurement performed with any terahertz system to-date. Using a silicon wafer as a test sample, we compare data of the ECOPS experiment to results obtained with a conventional terahertz TDS system and a mechanical micrometer gauge. We show that all systems provide consistent results within the measurement accuracy. Moreover, we perform thickness measurements of a rapidly moving sample and characterize the ECOPS setup with respect to time-domain dynamic range, signal-to-noise ratio, and spectral properties.