Publication Date:
2015-12-03
Description:
We report a Cu-catalyzed coupling between triarylaluminum reagents and alkyl halides to form arylalkanes. The reaction proceeds in the presence of N , N , N’ , N’ -tetramethyl- o -phenylenediamine (NN-1) as a ligand in combination with CuI as a catalyst. This catalyst system enables the coupling of primary alkyl iodides and bromides with electron-neutral and electron-rich triarylaluminum reagents and affords the cross-coupled products in good to excellent yields. Beilstein J. Org. Chem. 2015, 11, 2400–2407. doi:10.3762/bjoc.11.261
Keywords:
alkylationarylalkanescoppercross-couplingorganoaluminum
Electronic ISSN:
1860-5397
Topics:
Chemistry and Pharmacology
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