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  • 1
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    Treatment pathways using the OHDSI network [Medical Sciences] (2016)
    National Academy of Sciences
    Details
    Publication Date: 2016-07-06
    Description: Observational research promises to complement experimental research by providing large, diverse populations that would be infeasible for an experiment. Observational research can test its own clinical hypotheses, and observational studies also can contribute to the design of experiments and inform the generalizability of experimental research. Understanding the diversity of populations...
    Keywords: Sackler Colloquium on Drawing Causal Inference from Big Data
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    TOE1 inhibits HIV-1 replication [Immunology and Inflammation] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-07-01
    Description: Target of Egr1 (TOE1) is a nuclear protein localized primarily in nucleoli and Cajal bodies that was identified as a downstream target of the immediate early gene Egr1. TOE1 displays a functional deadenylation domain and has been shown to participate in spliceosome assembly. We report here that TOE1 can function...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
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    Hot fusion-evaporation cross sections of ^{45} Sc-induced reactions with lanthanide targets (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-09-24
    Description: Author(s): T. A. Werke, D. A. Mayorov, M. C. Alfonso, M. E. Bennett, M. J. DeVanzo, M. M. Frey, E. E. Tereshatov, and C. M. Folden, III Background: Sc 45 has rarely been studied as a projectile in fusion-evaporation reactions. The synthesis of new superheavy elements with Z 〉 118 will require projectiles with Z 〉 20 , and Sc 45 could potentially be used for this purpose. Purpose: Cross sections were measured for the x n and p x n exit c… [Phys. Rev. C 92, 034613] Published Tue Sep 22, 2015
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-02-14
    Description: Although it is generally accepted that cellular differentiation requires changes to transcriptional networks, dynamic regulation of promoters and enhancers at specific sets of genes has not been previously studied en masse. Exploiting the fact that active promoters and enhancers are transcribed, we simultaneously measured their activity in 19 human and 14 mouse time courses covering a wide range of cell types and biological stimuli. Enhancer RNAs, then messenger RNAs encoding transcription factors, dominated the earliest responses. Binding sites for key lineage transcription factors were simultaneously overrepresented in enhancers and promoters active in each cellular system. Our data support a highly generalizable model in which enhancer transcription is the earliest event in successive waves of transcriptional change during cellular differentiation or activation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681433/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681433/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arner, Erik -- Daub, Carsten O -- Vitting-Seerup, Kristoffer -- Andersson, Robin -- Lilje, Berit -- Drablos, Finn -- Lennartsson, Andreas -- Ronnerblad, Michelle -- Hrydziuszko, Olga -- Vitezic, Morana -- Freeman, Tom C -- Alhendi, Ahmad M N -- Arner, Peter -- Axton, Richard -- Baillie, J Kenneth -- Beckhouse, Anthony -- Bodega, Beatrice -- Briggs, James -- Brombacher, Frank -- Davis, Margaret -- Detmar, Michael -- Ehrlund, Anna -- Endoh, Mitsuhiro -- Eslami, Afsaneh -- Fagiolini, Michela -- Fairbairn, Lynsey -- Faulkner, Geoffrey J -- Ferrai, Carmelo -- Fisher, Malcolm E -- Forrester, Lesley -- Goldowitz, Daniel -- Guler, Reto -- Ha, Thomas -- Hara, Mitsuko -- Herlyn, Meenhard -- Ikawa, Tomokatsu -- Kai, Chieko -- Kawamoto, Hiroshi -- Khachigian, Levon M -- Klinken, S Peter -- Kojima, Soichi -- Koseki, Haruhiko -- Klein, Sarah -- Mejhert, Niklas -- Miyaguchi, Ken -- Mizuno, Yosuke -- Morimoto, Mitsuru -- Morris, Kelly J -- Mummery, Christine -- Nakachi, Yutaka -- Ogishima, Soichi -- Okada-Hatakeyama, Mariko -- Okazaki, Yasushi -- Orlando, Valerio -- Ovchinnikov, Dmitry -- Passier, Robert -- Patrikakis, Margaret -- Pombo, Ana -- Qin, Xian-Yang -- Roy, Sugata -- Sato, Hiroki -- Savvi, Suzana -- Saxena, Alka -- Schwegmann, Anita -- Sugiyama, Daisuke -- Swoboda, Rolf -- Tanaka, Hiroshi -- Tomoiu, Andru -- Winteringham, Louise N -- Wolvetang, Ernst -- Yanagi-Mizuochi, Chiyo -- Yoneda, Misako -- Zabierowski, Susan -- Zhang, Peter -- Abugessaisa, Imad -- Bertin, Nicolas -- Diehl, Alexander D -- Fukuda, Shiro -- Furuno, Masaaki -- Harshbarger, Jayson -- Hasegawa, Akira -- Hori, Fumi -- Ishikawa-Kato, Sachi -- Ishizu, Yuri -- Itoh, Masayoshi -- Kawashima, Tsugumi -- Kojima, Miki -- Kondo, Naoto -- Lizio, Marina -- Meehan, Terrence F -- Mungall, Christopher J -- Murata, Mitsuyoshi -- Nishiyori-Sueki, Hiromi -- Sahin, Serkan -- Nagao-Sato, Sayaka -- Severin, Jessica -- de Hoon, Michiel J L -- Kawai, Jun -- Kasukawa, Takeya -- Lassmann, Timo -- Suzuki, Harukazu -- Kawaji, Hideya -- Summers, Kim M -- Wells, Christine -- FANTOM Consortium -- Hume, David A -- Forrest, Alistair R R -- Sandelin, Albin -- Carninci, Piero -- Hayashizaki, Yoshihide -- P30 CA010815/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2015 Feb 27;347(6225):1010-4. doi: 10.1126/science.1259418. Epub 2015 Feb 12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25678556" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites ; Cattle ; Cell Differentiation/*genetics ; Dogs ; *Enhancer Elements, Genetic ; *Gene Expression Regulation, Developmental ; Mice ; RNA, Messenger/genetics/metabolism ; Rats ; Stem Cells/*cytology/metabolism ; Transcription Factors/*metabolism ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Catchment-based gold prospectivity analysis combining geochemical, geophysical and geological data across northern Australia (2017)
    Geological Society of London
    Details
    Publication Date: 2017-08-04
    Description: The results of a pilot study into the application of an unsupervised clustering approach to the analysis of catchment-based National Geochemical Survey of Australia (NGSA) geochemical data combined with geophysical and geological data across northern Australia are documented. NGSA Mobile Metal Ion® (MMI) element concentrations and first and second order statistical summaries across catchments of geophysical data and geological data are integrated and analysed using Self-Organizing Maps (SOM). Input features that contribute significantly to the separation of catchment clusters are objectively identified and assessed. A case study of the application of SOM for assessing the spatial relationships between Au mines and mineral occurrences in catchment clusters is presented. Catchments with high mean Au code-vector concentrations are found downstream of areas known to host Au mineralization. This knowledge is used to identify upstream catchments exhibiting geophysical and geological features that indicate likely Au mineralization. The approach documented here suggests that catchment-based geochemical data and summaries of geophysical and geological data can be combined to highlight areas that potentially host previously unrecognised Au mineralization.
    Print ISSN: 1467-7873
    Electronic ISSN: 1467-7873
    Topics: Chemistry and Pharmacology , Geosciences
    Published by Geological Society of London
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  • 6
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    Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential (2016)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2016-01-21
    Description: Haematopoietic stem cells (HSCs), which sustain production of all blood cell lineages, rely on glycolysis for ATP production, yet little attention has been paid to the role of mitochondria. Here we show in mice that the short isoform of a critical regulator of HSCs, Prdm16 (refs 4, 5), induces mitofusin 2 (Mfn2), a protein involved in mitochondrial fusion and in tethering of mitochondria to the endoplasmic reticulum. Overexpression and deletion studies, including single-cell transplantation assays, revealed that Mfn2 is specifically required for the maintenance of HSCs with extensive lymphoid potential, but not, or less so, for the maintenance of myeloid-dominant HSCs. Mfn2 increased buffering of intracellular Ca(2+), an effect mediated through its endoplasmic reticulum-mitochondria tethering activity, thereby negatively regulating nuclear translocation and transcriptional activity of nuclear factor of activated T cells (Nfat). Nfat inhibition rescued the effects of Mfn2 deletion in HSCs, demonstrating that negative regulation of Nfat is the prime downstream mechanism of Mfn2 in the maintenance of HSCs with extensive lymphoid potential. Mitochondria therefore have an important role in HSCs. These findings provide a mechanism underlying clonal heterogeneity among HSCs and may lead to the design of approaches to bias HSC differentiation into desired lineages after transplantation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Luchsinger, Larry L -- de Almeida, Mariana Justino -- Corrigan, David J -- Mumau, Melanie -- Snoeck, Hans-Willem -- 1S10OD020056-01/OD/NIH HHS/ -- 1S10RR027050-01/RR/NCRR NIH HHS/ -- F31 CA196045/CA/NCI NIH HHS/ -- R01 AG029262/AG/NIA NIH HHS/ -- R01 CA167286/CA/NCI NIH HHS/ -- England -- Nature. 2016 Jan 28;529(7587):528-31. doi: 10.1038/nature16500. Epub 2016 Jan 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Columbia Center for Translational Immunology, Columbia University Medical Center, New York, New York 10032, USA. ; Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA. ; Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York 10032, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26789249" target="_blank"〉PubMed〈/a〉
    Keywords: Active Transport, Cell Nucleus ; Animals ; Calcium/metabolism ; Calcium Signaling ; Cell Differentiation ; Cell Lineage ; DNA-Binding Proteins/chemistry/metabolism ; Endoplasmic Reticulum/metabolism ; Female ; Fibroblasts ; GTP Phosphohydrolases/*metabolism ; Hematopoietic Stem Cells/*cytology/*metabolism ; Lymphocytes/*cytology/metabolism ; Male ; Mice ; Mitochondria/metabolism ; Mitochondrial Dynamics ; Myeloid Cells/cytology ; NFATC Transcription Factors/antagonists & inhibitors/metabolism ; Transcription Factors/chemistry/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 7
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    Beyond the limits of 1D coherent synchrotron radiation (2018)
    Institute of Physics (IOP)
    Details
    Publication Date: 2018-07-20
    Description: An understanding of collective effects is of fundamental importance for the design and optimisation of the performance of modern accelerators. In particular, the design of an accelerator with strict requirements on the beam quality, such as a free electron laser (FEL), is highly dependent on a correspondence between simulation, theory and experiments in order to correctly account for the effect of coherent synchrotron radiation (CSR), and other collective effects. A traditional approach in accelerator simulation codes is to utilise an analytic one-dimensional approximation to the CSR force. We present an extension of the 1D CSR theory in order to correctly account for the CSR force at the entrance and exit of a bending magnet. A limited range of applicability to this solution—in particular, in bunches with a large transverse spot size or offset from the nominal axis—is recognised. More recently developed codes calculate the CSR effect in dispersive regions directly from the Lién...
    Electronic ISSN: 1367-2630
    Topics: Physics
    Published by Institute of Physics (IOP)
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  • 8
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    Influência da hidrociclonagem e da secagem por spray dryer nas propriedades reológicas de argilas bentoníticas (2015)
    SciELO Brazil
    Details
    Publication Date: 2015-09-01
    Description: ResumoA exploração desordenada ao longo dos anos das argilas bentoníticas do município de Boa Vista, PB, resultou no esgotamento das variedades nobres. Assim, o que existe atualmente são bentonitas com elevado percentual de minerais acessórios, elementos contaminantes a exemplo do quartzo, os quais influem negativamente nas propriedades reológicas das dispersões. O presente trabalho propõe concentrar dispersões dessas argilas pouco nobres pela operação de hidrociclonagem e posterior secagem por spray dryer, visando à obtenção de amostras com valores de reologia de acordo com norma EP-1EP-00011-A da Petrobrás. Assim, preparou-se dispersões de três composições com as argilas Bofe, Chocolate, Verde-Lodo, Chocobofe e Sortida previamente selecionadas por planejamento experimental com concentrações de 4% em massa de argila para serem concentradas por hidrociclonagem. Os concentrados foram secos por spray dryer em duas condições de secagem. Os resultados evidenciaram a eficiência das operações de hidrociclonagem e secagem por spray dryer das misturas com notável melhoria nas propriedades reológicas.
    Print ISSN: 0366-6913
    Electronic ISSN: 1678-4553
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by SciELO Brazil
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  • 9
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    Influência do tipo de argila no processo de solidificação/estabilização de lodo têxtil (2015)
    SciELO Brazil
    Details
    Publication Date: 2015-03-01
    Description: As argilas estão entre as mais importantes matérias-primas devido as suas múltiplas funções industriais. No caso especial da indústria de cerâmica vermelha, as argilas têm ampla utilidade, sendo o principal produto para a fabricação de telhas e blocos cerâmicos, que podem ser incorporados com resíduos industriais. Portanto, o objetivo deste trabalho foi estudar a influencia dos diferentes tipos de argilas na qualidade dos blocos cerâmicos de vedação, incorporados com lodo têxtil, por meio do processo de solidificação/estabilização. Avaliou-se a incorporação do lodo têxtil em 5 tipos de argilas, coletadas na região norte do Paraná, e realizou-se uma análise qualitativa dos blocos cerâmicos, com composição de 15% de resíduo têxtil, em função de suas características, estabelecidas nas normas da Associação Brasileira de Normas Técnicas. O resíduo utilizado foi proveniente de 12 indústrias têxteis de Maringá, PR. Inicialmente foi feita uma caracterização do lodo e das argilas. Os blocos cerâmicos foram fabricados em escala reduzida e submetidos a testes de resistência a compressão, lixiviação, solubilização e absorção de água, de acordo com as respectivas normas. Verificou-se nas condições estudadas que os blocos cerâmicos não apresentaram lixiviação nem solubilização. Portanto, o processo de solidificação/estabilização foi capaz de imobilizar de forma eficaz, os metais presentes no resíduo têxtil, mostrando-se como um promissor processo de minimização do impacto ambiental.
    Print ISSN: 0366-6913
    Electronic ISSN: 1678-4553
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by SciELO Brazil
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